Lifeboat Foundation

CRISPR technology is a simple yet powerful tool for editing genomes. It allows researchers to easily alter DNA sequences and modify gene function.

It has many potential applications include correcting genetic defects, treating and preventing the spread of diseases and improving crops. By delivering the CRISPR enzyme Cas9 nuclease coupled with synthetic guide RNA (gRNA) into a cell, the cell’s genome can be cut at a desired location, that allows existing genes to be removed or add new ones.

On April 29th and 30th, the XPRIZE Foundation hosted an event at its headquarters in Culver City, California that could have a profound effect on the evolving landscape of biorejuvenation research: the Future of Longevity Impact Roadmap Lab.

For those unfamiliar, the XPRIZE Foundation is famous for designing multi-million-dollar, global competitions to incentivize the development of technological breakthroughs, perhaps the most well-known being its first: the Ansari XPRIZE, which offered a $10,000,000 award for the first non-governmental organization to launch a reusable manned spacecraft into space twice within two weeks.

With this event, the purpose of which was to gather subject matter experts to brainstorm a potential longevity-research prize, XPRIZE has turned its focus towards solving the critical problem of age-related diseases on society and extending healthy human lifespan for all. As I was fortunate enough to directly participate in this exciting meeting, I’d like to share some of my experiences with you all.

Continue reading “Success at the XPRIZE Foundation” »

Exposure to environmental pollutants can cause alterations in brain development that affect sexual development and fertility for several generations, according to findings to be presented in Lyon, at the European Society of Endocrinology annual meeting, ECE 2019. The offspring of pregnant rats exposed to a mixture of common endocrine-disrupting chemicals (EDCs), at doses equivalent to those commonly experienced by people, showed impairments in sexual development and maternal behaviour that were passed on through several generations. These findings suggest that current levels of endocrine-disrupting chemicals in our environment may already be causing long-lasting harm and that people and agencies should take measures to minimise exposure.

Endocrine-disrupting chemicals can interfere with the normal function of our hormones and have previously been associated with infertility and altered sexual development in animals and people. We are exposed to hundreds of these pollutants in our daily lives, as they are used in the manufacture of plastics, pesticides and medicines. However, the extent of damage being done to our health and the consequences to future generations remains unclear. Rodent studies have suggested that exposure to EDCs can affect brain development through several generations but the generational effects on sexual development and reproduction have not previously been investigated.

In this study, David Lopez Rodriguez a graduate student in Anne-Simone Parent’s lab at the University of Liege in Belgium monitored the sexual development of three generations of rats, whose parent generation only were exposed to a mixture of common EDCs during pregnancy and lactation. The female rats born in the first and second generation showed impairments in their care for their own pups. However, the female rats in the second and third generation exhibited a delayed onset of puberty and altered reproductive cycle and ovarian follicle development, indicating that their fertility was affected, even though they were never themselves exposed to the EDCs. These changes were associated with altered gene expression in their brains that are known to affect how reproductive hormones are regulated.

Continue reading “Environmental toxins can impair sexual development and fertility of future generations” »

Brain-computer interfaces have managed some amazing feats: allowing paralyzed people to type words and move a robot using only their minds, to name two examples. Brown University neuroengineering professor Arto Nurmikko has had a hand in some of those developments, but even he says the technology is at only a rudimentary stage—the equivalent of the computer understanding the brain’s intention to bend a single finger.

“We’re trying to go from the bending-of-the-finger paradigm to tying shoe laces and even to the concert pianist level. That requires lots more spatial and temporal resolution from an electronic brain interface,” Nurmikko says. His team is hoping that kind of resolution will come along with the transition from a single, hard wired neural implant to a thousand or more speck-size neural implants that wirelessly communicate with computers outside the brain. At the IEEE Custom Integrated Circuits Conference, engineers from Brown University, Qualcomm, and the University of California San Diego presented the final part of a communications scheme for these implants. It allows bidirectional communication between the implants and an external device with an uplink rate of 10 megabits per second and a downlink rate of 1 Mb/s.

“We believe that we are the first group to realize wireless power transfer and megabits per second communications” in a neural implant, says Wing Ching (Vincent) Leung, technical director at the Qualcomm Institute Circuits Lab at UC San Diego.

Continue reading “Wireless Network Brings Dust-Sized Brain Implants a Step Closer” »

In hospitals, where many people are treated for life-threatening illnesses, having quality time with your doctor can be the difference between life and death.

However, physicians are often busy, seeing dozens of patients each day. So, then, how can we get more time with them? A.I., says physician and author Eric Topol. In this video, he explains how machine intelligence can free up doctors’ time while they go through their rounds.

Researchers develop new laser microscope that could be ‘revolutionary’ for treatment of diseases such as skin cancer. University of British Columbia researchers have developed a specialized microscope that has the potential ability to both diagnose diseases that include skin cancer and perform incredibly precise surgery – all without cutting skin.

University of British Columbia researchers have developed a specialized microscope that has the potential ability to both diagnose diseases that include skin cancer and perform incredibly precise surgery – all without cutting skin.

The researchers describe the technology in a study published today in Science Advances. “Our technology allows us to scan tissue quickly, and when we see a suspicious or abnormal cell structure, we can perform ultra-precise surgery and selectively treat the unwanted or diseased structure within the tissue – without cutting into the skin,” said Yimei Huang, co-lead author of the study and a former postdoctoral fellow at the department of dermatology and skin science at UBC and BC Cancer.

Continue reading “A New Way of Diagnosing and Treating Disease” »

The World Health Organization ranks Type 2 diabetes among the most common causes of death in the world. Current treatments can help the body use insulin at various stages of the disease, but they can also be expensive and subject patients to lifelong medication regimens and side effects. Thanks to new therapeutic ultrasound technology, one promising alternative looks to reshape how early Type 2 diabetes is managed.

A group of researchers from George Washington University in Washington, D.C., has used ultrasound therapy to stimulate insulin release from mice on demand. After exposing the pancreas, the body’s insulin production center, to ultrasonic pulses, the researchers saw measurable increases in the mice’s blood insulin levels.

The team will present their findings at the 177th Meeting of the Acoustical Society of America, which takes place from May 13–17, at the Galt House in Louisville, Kentucky.

Continue reading “Ultrasound used to trigger insulin release in mice shows promise for diabetes therapy” »

In 2018, researchers at the Biogerontology Research Foundation and the International Longevity Alliance submitted a joint proposal to the World Health Organization to re-classify aging as a disease. Months later, 11th Revision of the International Classification of Diseases (ICD-11) officially introduced some aging-related conditions such as age-associated cognitive decline.

This matters because, for the first time in human history, the once natural process of aging is becoming recontextualized as a condition to be treated and prevented. This will gradually lead to pharmaceutical companies and governments redirecting funding to new drugs and therapies that not only extend human life expectancy but reverse the effects of aging entirely.

Thus far, people in developed nations have seen their average life expectancy rise from ~35 in 1820 to 80 in 2003. And with the advances you’re about to learn about, you’ll see how that progression will continue until 80 becomes the new 40. In fact, the first humans expected to live to 150 may have already been born.

Continue reading “Future of human population” »

Besides biological immortality, there is also the possibility of digital immortality. The Human Connectome Project launched in 2010 aimed at mapping the entire human brain and to build its “network map” (connectome) to connect its structure to function and behaviour. Once the neural structure of the brain is completely deciphered, the mind can be uploaded into a computer that could control a robot that replicates a human in every respect.

The quest for eternal life is as old as humanity itself. “Grant us liberation from death for the sake of immortality, as the cucumber is severed from its bondage to the creeper”, runs one of the ancient Hindu prayers in the Mahamrityunjay, or the “great death-conquering” mantra. Death is the ultimate end, mysterious and terrible, against which even the strongest is powerless.

How to conquer death is a question every civilisation has tried to address. Myths have grown around immortal beings like gods in every culture, and of valiant but futile attempts of mortal men to attain immortality. But science may be closer to finding an answer to this ancient quest now more than ever before. In the early history of life, unicellular organisms like prokaryotes, protozoans and algae had ageless bodies and were immortal.

Continue reading “Quest for Immortality” »