Lifeboat Foundation

In a pair of related studies, a team of Yale researchers has found a way to reverse type-2 diabetes and liver fibrosis in mice, and has shown that the underlying processes are conserved in humans.

The studies appear in the Feb. 4 edition of Cell Reports and in the Jan. 17 edition of Nature Communications.

In the earlier study, researchers found an important connection between how the body responds to fasting and type-2 diabetes. Fasting “switches on” a process in the body in which two particular proteins, TET3 and HNF4α increase in the liver, driving up production of blood glucose. In type-2 diabetes, this “switch” fails to turn off when fasting ends, as it would in a non-diabetic person.

Researchers at Albany Medical College in New York have discovered that a specific type of immune cell accumulates in older brains, and that activating these cells improves the memory of aged mice. The study, which will be published on February 5, 2020, in the Journal of Experimental Medicine (JEM), suggests that targeting these cells might reduce age-related cognitive decline and combat aging-associated neurodegenerative disease in humans.

The brain is highly susceptible to aging, with cognitive functions, such as learning and memory, gradually declining as we get older. Much of the body’s immune system also deteriorates with age, resulting in increased susceptibility to infection and higher levels of inflammation. In their new JEM study, however, a team of researchers led by Qi Yang and Kristen L. Zuloaga at Albany Medical College reveal that aging-related changes in a class of immune cell known as group 2 innate lymphoid cells (ILC2s) could allow doctors to combat the effects of aging on the brain.

ILC2s reside in specific tissues of the body and help to repair them when they are damaged. Recently, for example, ILC2s in the spinal cord were shown to promote healing after spinal cord injury. “However, whether ILC2s also reside in other parts of the central nervous system, and how they respond to aging, was unknown,” Yang says.

Metarhizium anisopliae infects mosquitoes through the cuticle and proliferates in the hemolymph. To allow M. anisopliae to combat malaria in mosquitoes with advanced malaria infections, we produced recombinant strains expressing molecules that target sporozoites as they travel through the hemolymph to the salivary glands. Eleven days after a Plasmodium-infected blood meal, mosquitoes were treated with M. anisopliae expressing salivary gland and midgut peptide 1 (SM1), which blocks attachment of sporozoites to salivary glands; a single-chain antibody that agglutinates sporozoites; or scorpine, which is an antimicrobial toxin. These reduced sporozoite counts by 71%, 85%, and 90%, respectively. M. anisopliae expressing scorpine and an [SM1]₈:scorpine fusion protein reduced sporozoite counts by 98%, suggesting that Metarhizium-mediated inhibition of Plasmodium development could be a powerful weapon for combating malaria.

The diamondback moth is a huge pest. It eats a variety of crops, but is largely resistant to insecticides, resulting in upwards of $5 billion in losses every year.

That could soon change, though, as an international team of researchers has created a strain of genetically engineered diamondback moths that could suppress the pest population in a sustainable way — and they just released them into the wild for the first time.

For the study, published Wednesday in the journal Frontiers in Bioengineering and Biotechnology, the researchers engineered the moths so that when the males of the strain mated with wild females, the female offspring would die during the caterpillar life stage.

One day we may live in a world without disease.

A yarn-like material made from human skin cells could be used for surgery and complex tissue reconstruction without triggering an immune response.

Pre-historic times and ancient history are defined by the materials that were harnessed during that period.
We have the stone age, the bronze age, and the iron age.
Today is a little more complex, we live in the Space Age, the Nuclear Age, and the Information Age.
And now we are entering the Graphene Age, a material that will be so influential to our future, it should help define the period we live in.
Potential applications for Graphene include uses in medicine, electronics, light processing, sensor technology, environmental technology, and energy, which brings us to Samsung’s incredible battery technology!
Imagine a world where mobile devices and electric vehicles charge 5 times faster than they do today.
Cell phones, laptops, and tablets that fully charge in 12 minutes or electric cars that fully charge at home in only an hour.
Samsung will make this possible because, on November 28th, they announced the development of a battery made of graphene with charging speeds 5 times faster than standard lithium-ion batteries.
Before I talk about that, let’s quickly go over what Graphene is.
When you first hear about Graphene’s incredible properties, it sounds like a supernatural material out of a comic book.
But Graphene is real! And it is made out of Graphite, which is the crystallized form of carbon and is commonly found in pencils.
Graphene is a single atom thick structure of carbon atoms arranged in a hexagonal lattice and is a million time thinner than a human hair.
Graphene is the strongest lightest material on Earth.
It is 200 times stronger than steel and as much as 6 times lighter.
It can stretch up to a quarter of its length but at the same time, it is the hardest material known, harder than a diamond.
Graphene can also conduct electricity faster than any known substance, 140 times faster than silicone.
And it conducts heat 10 times better than copper.
It was first theorized by Phillip Wallace in 1947 and attempts to grow graphene started in the 1970s but never produced results that could measure graphene experimentally.
Graphene is also the most impermeable material known, even Helium atoms can’t pass through graphene.
In 2004, University of Manchester scientists Andre Geim and Konstantin Novoselov successfully isolated one atom thick flakes of graphene for the first time by repeatedly separating fragments from chunks of graphite using tape, and they were awarded the Nobel Prize in Physics in 2010 for this discovery.
Over the past 10 years, the price of Graphene has dropped at a tremendous rate.
In 2008, Graphene was one of the most expensive materials on Earth, but production methods have been scaled up since then and companies are selling Graphene in large quantities.

Sources:
http://www.graphene.manchester.ac.uk/explore/the-story-of-gr…rly-years/
https://en.wikipedia.org/wiki/History_of_graphene
https://en.wikipedia.org/wiki/Potential_applications_of_graphene
http://luratia.com/graphene/category/graphene-facts#sthash.3…mEmGp.dpbs
https://blogs.windows.com/devices/2013/02/07/hero-material-1…-graphene/
https://news.samsung.com/global/samsung-develops-battery-mat…ging-speed

But CRISPR editing — at least as a therapeutic technique in people — has turned out to be more difficult than initially thought. Researchers have documented ways that Cas9, one of the enzymes used in CRISPR gene editing, could trigger immune responses, or cause accidental changes to the genome that would be permanent. RNA editing, by contrast, could allow clinicians to make temporary fixes that eliminate mutations in proteins, halt their production or change the way that they work in specific organs and tissues. Because cells quickly degrade unused RNAs, any errors introduced by a therapy would be washed out, rather than staying with a person forever.

Making changes to the molecular messengers that create proteins might offer flexible therapies for cancer, pain or high cholesterol, in addition to genetic disorders.

A team of researchers at the French National Institute of Health and Medical Research in Bordeaux have grown yarn from human skin cells that they call a “human textile” — and they say it could be used by surgeons to close wounds or assemble implantable skin grafts.

“These human textiles offer a unique level of biocompatibility and represent a new generation of completely biological tissue-engineered products,” the researchers wrote in a paper published in the journal Acta Biomaterialia.

The key advantage of the gruesome yarn is that unlike conventional synthetic surgical materials, the material doesn’t trigger an immune response that can complicate the healing process, according to New Scientist.