Lifeboat Foundation

In a review published in the journal *Science*, Jain and Steele Laboratories colleagues Hadi T. Nia, PhD, and Lance L. Munn, PhD, describe four distinct physical hallmarks of cancer that affect both cancer cells and the tumor microenvironment, contributing to both tumor growth and the development of resistance to powerful cancer drugs.

One widely accepted model of cancer holds that a normal cell goes rogue because of genetic mutations or an environmental insult. In this model, the altered cell starts replicating out of control and takes over normal tissues, displaying eight hallmarks that include the ability to promote and sustain the growth of tumors, evade immune system attempts to suppress growth, stimulate blood flow to tumors and both invade local tissues and metastasize (spread) elsewhere in the body.

But this model fails to take into account how physical processes affect tumor progression and treatment, say the authors. In addition to the aforementioned eight biological hallmarks of cancer proposed by Robert Weinberg, PhD, from MIT, and Douglas Hanahan, PhD, from the Swiss Federal Institute of Technology in Lausanne, Jain and colleagues propose adding four distinct physical hallmarks that capture the biomechanical abnormalities in tumors: elevated solid stress; elevated interstitial fluid pressure; increased stiffness and altered material properties; and altered tissue micro-architecture.

Continue reading “Melding biology and physical sciences yields deeper understanding of cancer” »

In this interview to Allison Duettmann, Carolina Reis, OneSkin’s CEO, describes the results of the prove of concept clinical study that the company performed for the product launched in the market some weeks ago, and explains more thoroughly the possible mechanisms of action involved in the reduction of senescent cells in the skin.

Zoom Transcription: https://otter.ai/s/DxPPE-AMSl6VdZa4K8dkDQ

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

Researchers at the Department of Energy’s Oak Ridge National Laboratory used neutron scattering to identify key information to improve the effectiveness of drug inhibitors designed to block the virus’s replication mechanism. The research is published in the Journal of Biological Chemistry.

The SARS-CoV-2 virus, which causes the COVID-19 disease, expresses long chains of proteins composed of approximately 1,900 amino acid residues. For the virus to reproduce, those chains have to be broken down and cut into smaller strands by an enzyme called the main protease. The active protease enzyme is formed from two identical protein molecules held together by hydrogen bonds. Developing a drug that inhibits or blocks the protease activity will prevent the virus from replicating and spreading to other cells in the body.

https://www.youtube.com/watch?v=RJQcvGALwZY&feature=youtu.be

A closer look at Stentrode, the Brain Computer Interface that interacts with the brain via blood vessels. Recent paper demonstrating it working in 2 ALS patients.

Han from WrySci HX goes through the very interesting brain computer interface called Stentrode that can let you tweet with your mind. As a BCI, it’s a rival to Neuralink, Kernal, and Openwater. Find out about its background, how it works, why it’s the most unique BCI, and some results from its clinical trials. More below ↓↓↓

Continue reading “Tweeting with your MIND? Meet Stentrode: The Neuralink Rival ALREADY in Clinical Trials” »

Li’l Kurt is a genetic marvel.

In an effort to increase genetic diversity among horses, scientists have gone sci-fi and used frozen 40-year-old cells to create Kurt, the very first clone of a Przewalski’s horse.

Continue reading “Scientists Cloned the Most Endangered Horse in the World—From 40-Year-Old DNA” »

Mice who ate a diet high in fat and cholesterol were more likely to see their hair turn from black to white and experience hair loss. The diet also appeared to cause inflammation of the skin.

In the first stage of the study, the researchers genetically modified mice to develop atherosclerosis, a condition in which fat deposits form in the arteries.

They then fed mice either a Western diet high in fat and cholesterol or untreated rat chow from the age of 12 to 20 weeks. As expected, the mice who consumed the Western diet saw their hair turn white and fall out, and develop skin lesions. And the longer the mice ate the diet, the worse their symptoms became. By week 36, three quarters of the animals had skin lesions.

New research^[1] presented at the 29th EADV Congress, EADV Virtual, shows that socks coated in zinc oxide nanoparticles (ZnO-NPs) can prevent bromodosis (foot odor) and pitted keratolysis (bacterial infection causing smelly feet), reducing the negative impact this embarrassing condition has on quality of life.^[2]

Developed by the Royal Thai Airforce, the ZnO-NP-coated socks were trialed in a real-life setting by researchers at Siriraj Hospital, Mahidol University in Thailand. They found that the antibacterial efficacy of ZnO-NPs, along with its safety and compatibility with human skin, makes it the perfect compound to incorporate into textiles, including socks, to prevent unpleasant foot odor.

The double-blinded, randomized, controlled trial was conducted with 148 cadets at the Thai Naval Rating School. Bromodosis and pitted keratolysis are a common complaint in military personnel, with foot lesions, including pitted keratosis, occurring in over a third of naval cadets in Thailand (38.5%).^[2]

Hundreds of American hospitals are being targeted in cyberattacks by the same Russian hackers who American officials and researchers fear could sow mayhem around next week’s election.

The attacks on American hospitals, clinics and medical complexes are intended to take those facilities offline and hold their data hostage in exchange for multimillion-dollar ransom payments, just as coronavirus cases spike across the United States.

“We expect panic,” one hacker involved in the attacks said in Russian during a private exchange on Monday that was captured by Hold Security, a security company that tracks online criminals.

The result is a science park and university campus that offers degrees at all levels. It hosts more than 300 labs and advanced research equipment, such as the SOLEIL synchrotron. About 100 companies and 6 of France’s public research organizations, including the national research agency CNRS, have a presence there. That combination — of the university with national facilities — is powerful, says Price. The park accounts for an estimated 15% of France’s public and private research. About 30,000 people work or study at Saclay, and this is projected to rise to 80,000 by 2030.

The lab has no overall scientific project, and has added an extra layer of management, says Fayard, although he concedes that the coronavirus pandemic has complicated the lab’s first months. “I fear the lab will have to work hard not to fall between two stools — it is too big to be efficient, but not big enough to invest alone in major local infrastructures.”

But Oliver Brüning, a particle physicist at CERN, Europe’s particle physics lab near Geneva, Switzerland, who spent time working at LAL, says he thinks the new lab has greater weight and influence than did LAL alone.

Continue reading “How France overcame the odds to build a research mega-campus” »