Lifeboat Foundation

The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood. This condition is rare, and is known as Li-Fraumeni syndrome. However, mutations in p53 are found in most tumor types, and so contribute to the complex network of molecular events leading to tumor formation.

The p53 gene has been mapped to chromosome 17. In the cell, p53 protein binds DNA, which in turn stimulates another gene to produce a protein called p21 that interacts with a cell division-stimulating protein (cdk2). When p21 is complexed with cdk2 the cell cannot pass through to the next stage of cell division. Mutant p53 can no longer bind DNA in an effective way, and as a consequence the p21 protein is not made available to act as the ‘stop signal’ for cell division. Thus cells divide uncontrollably, and form tumors.

Help with unraveling the molecular mechanisms of cancerous growth has come from the use of mice as models for human cancer, in which powerful ‘gene knockout’ techniques can be used. The amount of information that exists on all aspects of p53 normal function and mutant expression in human cancers is now vast, reflecting its key role in the pathogenesis of human cancers. It is clear that p53 is just one component of a network of events that culminate in tumor formation.

Researchers at MIT and the University of Waterloo have developed a high-power, portable version of a device called a quantum cascade laser, which can generate terahertz radiation outside of a laboratory setting. The laser could potentially be used in applications such as pinpointing skin cancer and detecting hidden explosives.

Until now, generation of terahertz radiation powerful enough to perform real-time imaging and fast spectral measurements required temperatures far below 200 Kelvin (−100 degrees Fahrenheit) or lower. These temperatures could only be achieved with bulky equipment that limited the technology’s use to a laboratory setting. In a paper published in Nature Photonics, MIT Distinguished Professor of Electrical Engineering and Computer Sciences Qing Hu and his colleagues report that their terahertz quantum cascade laser can function at temperatures of up to 250 K (−10 degrees Fahrenheit), meaning that only a compact portable cooler is required.

Terahertz quantum cascade lasers, tiny chip-embedded semiconductor laser devices, were first invented in 2002, but adapting them to operate far above 200 K proved to be so difficult that many people in the field speculated that there was a fundamental physical reason preventing it, Hu says.

Has anyone here done a DNA test for longevity? I’m curious if you have any experiences with specific companies you can share. I researched 7 different big ones and am trying to decide which to go with.

Note: This is the second in our series of posts about the best DNA tests for health and longevity. To better understand the basics of DNA and the different types of DNA tests on the market please go back and read the first piece on The Benefits of Genetic Testing for Longevity.

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SpaceX rolled-out Starlink beta internet service in northern United States and southern Canada in October. To date, SpaceX has deployed around 888 internet-beaming satellites out of the 4,409 that will operate in low Earth orbit. SpaceX is looking forward to connecting locations around the world where internet connection is unreliable and non-existent. Earlier this year, SpaceX engineers said Starlink is capable of beaming internet connection to remote areas on Earth; 60 Starlink satellites have the capability to beam low-latency, high-speed broadband internet to 40,000 users streaming high-definition videos simultaneously. Starlink customers receive service via a phased-array antenna dish and Wi-Fi router device. Additionally, SpaceX will build hundreds of ground stations that will receive the satellite’s communication. The stations are the linking factor between user terminals and data center for the Starlink network.

The Australian Communications and Media Authority (ACMA) which regulates telecommunications service, granted SpaceX a telecommunications license to offer internet on August 7th this year. SpaceX recieved approval to operate ground stations on October 26. ACMA granted SpaceX licenses to operate a total of 24 Starlink ground stations in Australia, according to a document published by the regulatory agency.

Approximately 2.5 million individuals in Australia still lack access to internet at home due to the service being either too expensive or unavailable in the rural location they reside in. Connecting rural areas around the globe to the network provides benefits to civilization as a whole. The Internet provides an equal chance for everyone to have access to education and job opportunites at their fingertips. Amid the Coronavirus outbreak, the digital divide among communites became more apparent, many students had to study from home but their households did not have internet service. SpaceX hopes to close the digital divide in rural areas worldwide. As more satellites are deployed to orbit, SpaceX will expand broadband coverage to Australia and the rest of the planet in 2021.

Summary: A bacterium found in the soil close to the roots of ginseng plants, appears to significantly dissociate the protein aggregates associated with Alzheimer’s disease.

Source: Wiley

A bacterium found among the soil close to roots of ginseng plants could provide a new approach for the treatment of Alzheimer’s. Rhizolutin, a novel class of compounds with a tricyclic framework, significantly dissociates the protein aggregates associated with Alzheimer’s disease both in vivo and in vitro, as reported by scientists in the journal Angewandte Chemie.

Hello World.

I’m Imagination.

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Researchers at Stanford University have developed a CRISPR-based “lab on a chip” to detect COVID-19, and are working with automakers at Ford to develop their prototype into a market-ready product.

This could provide an automated, hand-held device designed to deliver a coronavirus test result anywhere within 30 minutes.

In a study published this week in the Proceedings of the National Academy of Sciences, the test spotted active infections quickly and cheaply, using electric fields to purify fluids from a nasal swab sample and drive DNA-cutting reagents within the system’s tiny passages.

Summary: DMT, a natural component of ayahuasca tea, promotes neurogenesis, a new study reports. Researchers found DMT was capable of activating neural stem cells and promoted the formation of new neurons.

Source: Complutense University of Madrid.

One of the main natural components of ayahuasca tea, dimethyltryptamine (DMT), promotes neurogenesis (the formation of new neurons) according to research led by the Complutense University of Madrid (UCM).

Dr David Sinclair (Harvard) : “I want to mention one thing that nobody except the insiders would know, is that I was at a conference a couple weeks ago with all 15 of us talking about this reprogramming work, and a lot of it is not published yet. I’ve seen things that make my head spin, the ability to turn back aging in a whole animal,…”

On October 27, 2020, Glaucoma Research Foundation presented the 2020 Weston Lecture featuring a talk by world-renowned Harvard Medical School genetics researcher and best-selling author David Sinclair, PhD, AO discussing longevity research and glaucoma.

Continue reading “Seeing the Future: Longevity Research and Glaucoma (Video)” »