Lifeboat Foundation

Making living cells blink fluorescently like party lights may sound frivolous. But the demonstration that it’s possible could be a step toward someday programming our body’s immune cells to attack cancers more effectively and safely.

That’s the promise of the field called synthetic biology. While molecular biologists strip cells down to their component genes and molecules to see how they work, synthetic biologists tinker with cells to get them to perform new feats — discovering new secrets about how life works in the process. In this episode, Steven Strogatz talks with Michael Elowitz, a professor of biology and bioengineering at the California Institute of Technology and a Howard Hughes Medical Institute Investigator.

High-performance, realistic computer simulations are crucially important for science and engineering, even allowing scientists to predict how individual molecules will behave.

Watch the Q&A here: https://youtu.be/aRGH5lC0pLc.
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Continue reading “Computer modelling for molecular science — with Sir Richard Catlow” »

Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.

New findings from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) make it possible for the first time to monitor the functional development and maturation of cardiomyocytes—the cells responsible for regulating the heartbeat through synchronized electrical signals —on the single-cell level using tissue-embedded nanoelectronic devices. The devices—which are flexible, stretchable, and can seamlessly integrate with living cells to create “cyborgs”—are reported in a Science Advances paper.

“These mesh-like nanoelectronics, designed to stretch and move with growing tissue, can continuously capture long-term activity within individual stem-cell derived cardiomyocytes of interest,” says Jia Liu, co-senior author on the paper, who is an assistant professor of bioengineering at SEAS, where he leads a lab dedicated to bioelectronics.

Robots are all around us, from drones filming videos in the sky to serving food in restaurants and diffusing bombs in emergencies. Slowly but surely, robots are improving the quality of human life by augmenting our abilities, freeing up time, and enhancing our personal safety and well-being. While existing robots are becoming more proficient with simple tasks, handling more complex requests will require more development in both mobility and intelligence.

Columbia Engineering and Toyota Research Institute computer scientists are delving into psychology, physics, and geometry to create algorithms so that robots can adapt to their surroundings and learn how to do things independently. This work is vital to enabling robots to address new challenges stemming from an aging society and provide better support, especially for seniors and people with disabilities.

Continue reading “Engineers use psychology, physics, and geometry to make robots more intelligent” »

CRISPR gene editing has made it possible to cure sickle cell disease, which affects millions worldwide, but most people with the condition won’t be able to afford the cost of the treatment.

By Michael Le Page

Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro. Coining the term “organoid intelligence” (OI) to encompass these developments, we present a collaborative program to implement the vision of a multidisciplinary field of OI. This aims to establish OI as a form of genuine biological computing that harnesses brain organoids using scientific and bioengineering advances in an ethically responsible manner. Standardized, 3D, myelinated brain organoids can now be produced with high cell density and enriched levels of glial cells and gene expression critical for learning. Integrated microfluidic perfusion systems can support scalable and durable culturing, and spatiotemporal chemical signaling.

Forget about He Jiankui, the Chinese scientist who created gene-edited babies. Instead, when you think about gene editing you should think of Victoria Gray, the African-American woman who says she’s been cured of her sickle-cell disease symptoms.

This week in London, scientists are gathering for the Third International Summit on Human Genome Editing. It’s gene editing’s big event, where researchers get to awe the audience with their new ability to modify DNA—and ethicists get to worry about what it all means.

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In this Ask Me Anything interview, Prof. Matt Kaeberlein discusses the evidence (and lack thereof) behind popular anti-aging supplements and interventions. Starting from his current research on rapamycin for healthy longevity in dogs (The Dog Aging Project), he describes the promises and perils of anti-aging medicine and shares with us some tips on how to become better critical thinkers and protect us from hype and snake oil.

Continue reading “Anti-aging Supplements: Science, Snake Oil, and How Do We Know?” »

Artificial Intelligence AI

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Continue reading “Singularity Timeline | Is Super Artificial Intelligence The END of Humanity?” »