Lifeboat Foundation

Cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer allowed scientists to discover a molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer, glioblastoma.

Published findings in Cell Stem Cell describe how the single-cell analyses identified a subpopulation of cells critical to glioblastoma formation—the early primitive progenitor cells of oligodendrocyte brain cells, pri-OPC progenitors, according to Q. Richard Lu, Ph.D., lead investigator and Scientific Director of the Brain Tumor Center at Cincinnati Children’s Hospital Medical Center.

The data suggest that reprogramming of primitive oligodendrocyte progenitors into a stem-like state plays an important role in glioma initiation and progression. The researchers’ primary molecular target in the study, a protein called Zfp36l1, launches biological programs that mirror those of healthy early brain development in the mice, but instead help fuel brain cancer growth. The discovery presents an opportunity to find out if new therapeutic approaches can stop glioblastoma at its earliest stages of initial formation or recurrence, Lu said.

Continue reading “Shutting down deadly pediatric brain cancer at its earliest moments” »

MIT’s Computer Science and Artificial Intelligence Lab (CSAIL) is developing a robot that sorts for recycling. Fundamentally, the squad’s robot arm has soft grippers ad the robot can take objects from a conveyor belt and identify what they are made from— by touch.

Tactile sensors on the robot are the main feature. The sensorized gripper is fully electrical driven. It can detect the difference between paper, metal and plastic.

Continue reading “Recycling robot can use sense of touch to sort through the trash” »

In fact, according to IRENA’s new report, the most cost-effective strategy to achieve a “climate-safe future” — keeping global warming below 2 degrees Celsius (3.6 degrees Fahrenheit) — is an accelerated energy transition to renewables and energy efficiency coupled with electrification of key sectors like transportation.

This Renewable Energy Roadmap (REmap) scenario “would also save the global economy up to USD 160 trillion cumulatively over the next 30 years in avoided health costs, energy subsidies and climate damages.”

At the same time, IRENA reports, “every dollar spent on energy transition would pay off up to seven times.”

Continue reading “Global economy would save up to $160 trillion” »

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice—findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in the journal Science.

Major depression is one of the most common mental disorders in the United States, with approximately 17.3 million adults experienced a major depressive episode in 2017. However, many of the neural changes underlying the transitions between active depression, remission, and depression re-occurrence remain unknown. Ketamine, a fast-acting antidepressant which relieves depressive symptoms in hours instead of weeks or longer, provides an opportunity for researchers to investigate the short- and long-term biological changes underlying these transitions.

“Ketamine is a potentially transformative treatment for depression, but one of the major challenges associated with this drug is sustaining recovery after the initial treatment,” said study author Conor Liston, M.D., Ph.D., of Weill Cornell Medicine, New York City.

Continue reading “Ketamine reverses neural changes underlying depression-related behaviors in mice” »

The ions at its core will be seven times hotter than those of the real Sun.

In quantum physics, a vacuum is not empty, but rather steeped in tiny fluctuations of the electromagnetic field. Until recently it was impossible to study those vacuum fluctuations directly. Researchers at ETH Zurich have developed a method that allows them to characterize the fluctuations in detail.

Emptiness is not really empty – not according to the laws of quantum physics, at any rate. The vacuum, in which classically there is supposed to be “nothing,” teems with so-called vacuum fluctuations according to quantum mechanics. Those are small excursions of an electromagnetic field, for instance, that average out to zero over time but can deviate from it for a brief moment. Jérôme Faist, professor at the Institute for Quantum Electronics at ETH in Zurich, and his collaborators have now succeeded in characterizing those vacuum fluctuations directly for the first time.

“The vacuum fluctuations of the electromagnetic field have clearly visible consequences, and among other things, are responsible for the fact that an atom can spontaneously emit light,” explains Ileana-Cristina Benea-Chelmus, a recently graduated Ph.D. student in Faists laboratory and first author of the study recently published in the scientific journal Nature. “To measure them directly, however, seems impossible at first sight. Traditional detectors for light such as photodiodes are based on the principle that light particles – and hence energy – are absorbed by the detector. However, from the vacuum, which represents the lowest energy state of a physical system, no further energy can be extracted.”

Continue reading “Fluc­tu­a­tions in the void” »

The first commercial flight of SpaceX’s Falcon Heavy ended with two boosters touching down on land while a third alighted on its drone ship out at sea.

Guest writer Dr. Asimina Pantazi gives her impressions of the recent Berlin Undoing Aging Conference from the point of view of someone working in research.

As a millennial with limited orientation abilities but expertise with digital tools, I used Google Maps to find the venue, fearing that I would have no data and would get lost in Berlin, only to find out that I was only a couple of meters away from to the venue entrance.

The Undoing Aging 2019 conference took place on May 28–30 at Umspannwerk Alexanderplatz: a multi-level industrial setting, with metal stairs, funky lights, and a balcony overlooking the minimal conference hall. This gave me my first positive vibes.

Continue reading “Undoing Aging 2019: Highlights and Impressions” »

A team of scientists recently revealed they’d successfully conducted experiments on hundreds of pigs that involved keeping their brains alive for up to 36 hours after the animals had been decapitated.

Maybe Sergio Canavero, the mad scientist who wants to perform a brain transplant on a human, isn’t so crazy after all.