Lifeboat Foundation

Researchers at the Buck Institute have extensively profiled the various inflammatory signals given off by senescent human cells and have generated a curated database available for use in the field.

Senescent cells, which stop dividing under stress, are long- recognized drivers of multiple diseases of aging. Mouse studies have shown that targeted removal of these cells and the inflammatory factors they secrete, known as the senescence-associated secretory phenotype (SASP), has beneficial results on multiple organ systems and functions. Success in the laboratory has given rise to companies and research projects aimed at developing either senolytics, drugs that clear senescent cells, or senomorphics, drugs that suppress the SASP. But drug development and clinical utilization require simple, reliable biomarkers to assess the abundance of senescent cells in human tissues. Publishing in PLOS Biology, researchers at the Buck Institute have extensively profiled the SASP of human cells and have generated a curated database available for use in the field.

“The stage is now set for the development of clinically-relevant biomarkers of aging,” said Judith Campisi, Ph.D., Buck professor and one of the senior authors on the paper. “This will speed efforts to get safe and effective drugs into the clinic and, in the long term, could enable physicians to give patients a clear read-out of how well, or poorly, their various tissues and organs are aging.”

Continue reading “Stage is set to develop clinically relevant, senescence-based biomarkers of aging” »

The Black Vault has more than 2,000,000 pages of declassified U.S. Government documents ready to download on nearly any government secret you can imagine. Utilizing the Freedom of Information Act (FOIA), The Black Vault’s founder John Greenewald, Jr. has filed more than 8,000 FOIA requests to amass it all.

Players applaud, say words like Whoo, bang plastic knives on the table and enjoy the best weekends with artificial intelligence as the main act, thanks to AI unleashed in games.

WIRED UK’s science editor, Matt Reynolds, looked at DeepMind’s impact on AI milestones: “It has outplayed Go champions, bested professional StarCraft players and turned its attention to chess and shogi.”

Let the games continue but the serious stuff must seriously shine. In brief, we can admire that unleashing AI for the purpose of scientific discovery has become especially alive and well thanks to research at DeepMind.

A startup focused on “invisible computing” Thursday unveiled a smart contact lens which delivers an augmented reality display in a user’s field of vision.

The Mojo Vision contact lens offers a display with information and notifications, and allows the user to interact by focusing on certain points.

The rigid contact lens, which the company has been developing in stealth mode for some 10 years, may also be used to help people with visual impairments by using enhanced image overlays, and has obtained US approval for testing it as a medical device.

The Big Hybrid Cat Breaks World Record for Being the Largest Feline In the Entire World

Once upon a time, 12,000 years ago, to be exact, tall, large tigers called the sabre-tooth tigers used to rule the world. They were so big that their very existence threatened humans daily.

Continue reading “A Hybrid Lion-Tiger is The Largest Cat In The World, Breaking The Guinness Record!” »

Levi’s debuted a soft cotton-hemp blend, and its head of innovation expects to have 100% cottonized-hemp garments in five years.

A dumbbell-shaped nanoparticle powered just by the force and torque of light has become the world’s fastest-spinning object.

Scientists at Purdue University created the object, which revolves at 300 billion revolutions per minute. Or, put another way, half a million times faster than a dentist’s drill.

In addition, the silica nanoparticle can serve as the world’s most sensitive torque detector, which researchers hope will be used to measure the friction created by quantum effects.

Mars’ mysterious and unexplored poles may also harbor pockets of biology, says one planetary scientist.

Rare mounds of a crystalline mineral have emerged above the surface of Utah’s Great Salt Lake, where they’re expected to remain just a few months before disappearing again.

Scientists think these mounds may be similar to mineral structures on Mars that could preserve traces of microbes that may have lived in the planet’s saltwater lakes billions of years ago.