Mar 5, 2020
Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017–2018 influenza season. — PubMed — NCBI
Posted by Brent Ellman in category: biotech/medical
“Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference…” “…Examining virus interference by specific respiratory viruses showed mixed results. Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus; however, significant protection with vaccination was associated not only with most influenza viruses, but also parainfluenza, RSV, and non-influenza virus coinfections.”
Vaccine. 2020 Jan 10;38:350–354. doi: 10.1016/j.vaccine.2019.10.005. Epub 2019 Oct 10.
PURPOSE: Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference. Test-negative study designs are often utilized to calculate influenza vaccine effectiveness. The virus interference phenomenon goes against the basic assumption of the test-negative vaccine effectiveness study that vaccination does not change the risk of infection with other respiratory illness, thus potentially biasing vaccine effectiveness results in the positive direction. This study aimed to investigate virus interference by comparing respiratory virus status among Department of Defense personnel based on their influenza vaccination status. Furthermore, individual respiratory viruses and their association with influenza vaccination were examined.