Lifeboat Foundation

Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions. Such stem cells, known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy), develop into cartilage cells that produce a biologic anti-inflammatory drug that, ideally, will replace arthritic cartilage and simultaneously protect joints and other tissues from damage that occurs with chronic inflammation.

A new automated machine can synthesize a range of small organic molecules with the push of a button. The synthesizer uses a chemical method that pieces together molecules from modular building blocks. With this technique, the machine synthesized 14 classes of molecules, including some complicated ones with multiple rings.

Perception-Action loops are at the core of most our daily life activities. Subconsciously, our brains use sensory inputs to trigger specific motor actions in real time and this becomes a continuous activity that in all sorts of activities from playing sports to watching TV. In the context of artificial intelligence(AI), perception-action loops are the cornerstone of autonomous systems such as self-driving vehicles. While disciplines such as imitation learning or reinforcement learning have certainly made progress in this area, the current generation of autonomous systems are still nowhere near human skill in making those decisions directly from visual data. Recently, AI researchers from Microsoft published a paper proposing a transfer learning method to learn perception-action policies from in a simulated environment and apply the knowledge to fly an autonomous drone.

The challenge of learning which actions to take based on sensory input is not so much related to theory as to practical implementations. In recent years, methods like reinforcement learning and imitation learning have shown tremendous promise in this area but they remain constrained by the need of large amounts of difficult-to-collect labeled real world data. Simulated data, on the other hand, is easy to generate, but generally does not render safe behaviors in diverse real-life scenarios. Being able to learn policies in simulated environments and extrapolate the knowledge to real world environments remains one of the main challenges of autonomous systems. To advance research in this area, the AI community has created many benchmarks for real world autonomous systems. One of the most challenging is known as first person view drone racing.

In first-person view(FPV) done racing, expert pilots are able to plan and control a quadrotor with high agility using a potentially noisy monocular camera feed, without comprising safety. The Microsoft Research team attempted to build an autonomous agent that can control a drone in FPV racing.

Electric dipole propulsion bigsmile

One reason we look so often at sail technologies in these pages is that they offer us ways of leaving the propellant behind. But even as we enter the early days of solar sail experimentation in space, we look toward ways of improving them by somehow getting around their need for solar photons. Robert Zubrin’s work with Dana Andrews has helped us see how so-called magnetic sails (magsails) could be used to decelerate a craft as it moved into a destination system. Now Zubrin looks at moving beyond both this and solar wind-deflecting electric sails toward an ingenious propellantless solution. Zubrin presented the work at last April’s Breakthrough Discuss meeting, and today he fills us in on its principles and advantages. Read on for a look at a form of enhanced electric sail the author has christened the Dipole Drive.

by Robert Zubrin

Continue reading “The Dipole Drive: A New Concept for Space Propulsion” »

I have not been a supporter of an extended public quarantine or shut down, if any. There are a number of reasons why (governments steal liberty during such times; national debt increases and is used to the point of total socialism; inequality becomes permanent; etc), but in this letter below to everyone I want to talk specifically about why a quarantine is ultimately harming the life extension and #transhumanism movements. Don’t ever forget, we are in a race to save the lives of “everyone” right now with the plague of aging, not just those who might get #coronavirus.

Dear Fellow Humans.

If you believe in the life extension movement of trying to live indefinitely through science and technology, then you likely should not support the worldwide quarantine (at least don’t support it over 14 days in the West where we don’t have the ability to do it as efficiently as Asia). It’s horrible that so many lives will be lost by COVID-19, but in a worse-case scenario it’s likely 100 million people will die globally (mostly older people who have only a few years left to live due to their underlying medical conditions of aging — and who have likely been kept alive due to science and 21st Century medicine anyway). But the damage we could cause (and almost certainly are causing) with the quarantine and shut down to the US and global economy may cost the life extension movement and its scientific research possibly three to five years of progress — because the funding, projects, and jobs around the anti-aging industry will disappear for a notable time. The math shows that if we achieve indefinite lifespans for the human race by the year 2035 vs 2040, approximately 250 million lives will be spared and could then go on indefinitely. The aging math (or life hours) for any transhumanist shows that if we care about human life and longevity — about how long people alive today live — then we should not quarantine the world right now, but get the economy going again as a first priority so that we may fund the future of anti-aging science for the species. Some of us call this reasoning the Transhumanist Wager. For the sake of everyone alive today, it must be acknowledged that there is a dramatically larger percent gain (many thousands of percent) of overall life years for our species by not quarantining and shutting down the world. This is all a horrible scenario, and one I am terribly sad to share with you, but that doesn’t mean we should cower from facts. We owe our species the most courageous decision for its long-term longevity of all its living citizens.

Continue reading “A Letter About Coronavirus, the Longevity Movement, & Why Quarantining is Killing Us” »

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

The researchers also found that elderly mice regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating protein treatment and transplanted back into their bodies.

The proteins, known as Yamanaka factors, are commonly used to transform an adult cell into what are known as induced pluripotent stem cells, or iPS cells. Induced pluripotent stem cells can become nearly any type of cell in the body, regardless of the cell from which they originated. They’ve become important in regenerative medicine and drug discovery.

New research suggests that digestive symptoms, including a loss of appetite and diarrhea, are more common in people with COVID-19 than doctors had thought.

Coronavirus RNA survived for up to 17 days aboard the Diamond Princess cruise ship, living far longer on surfaces than previous research has shown, according to new data published Monday by the Centers for Disease Control and Prevention.

The study examined the Japanese and U.S. government efforts to contain the COVID-19 outbreaks on the Carnival-owned Diamond Princess ship in Japan and the Grand Princess ship in California. Passengers and crew on both ships were quarantined on board after previous guests, who didn’t have any symptoms while aboard each of the ships, tested positive for COVID-19 after landing ashore.

The RNA, the genetic material of the virus that causes COVID-19, “was identified on a variety of surfaces in cabins of both symptomatic and asymptomatic infected passengers up to 17 days after cabins were vacated on the Diamond Princess but before disinfection procedures had been conducted,” the researchers wrote, adding that the finding doesn’t necessarily mean the virus spread by surface.

By Bill D’Zio March 24, 2020 (Originally posted on www.westeastspace.com)

WestEastSpace mapped out NASA locations on a map of COVID19 impacted areas of USA from www.usafacts.org as of March 23rd, 2020With the launch window for NASA’s Mars Perseverance rover opening in a little less than four months, there are nearly daily pre-launch milestones to complete the rover pre flight activities at the Kennedy Space Center in Cape Canaveral, Florida. Tight schedules on complex missions usually do not mix well. Now NASA has to contend with another challenge. COVID19.

NASA Leadership Assessing Mission Impacts of Coronavirus

The world has come to a standstill and is in the grasps of the COVID-19. The world stock markets have come crashing down 30% as supply chains and companies attempt to deal with government response and public fear. Airlines and hotels have had to contend with decreased travel and lodging requirements. Logistics is impacted as factories in various countries deal with increased difficulty and requirements to obtain goods. Factories are closed leading to shortages for truckers, material movers, cargo agents, and other occupations directly involved in moving goods. Companies shift to working remotely in an attempt to comply with government guidance in attempts to minimize the impact of the virus. One Mars mission has already been sidelined because of COVID19. NASA also needs to contend with these challenges.

Continue reading “Coronavirus Pandemic Impact on Space Programs Part I” »