Lifeboat Foundation

RENO, Nev. (News 4 & Fox 11) — A Reno company has been awarded more than $550 million to help make ventilators during the coronavirus outbreak.

In a statement released on Friday, Rep. Mark Amodei, R-Nev., said Hamilton Medical would receive a five-month, $551 million contract as part of a national effort to stockpile 100,000 ventilators over the next 100 days.

Amodei states the money is coming in the form of a firm-fixed-price contract that began on March 31.

Low-frequency ultrasound destroys cancer cells while leaving most healthy cells intact.

On Friday, an interplanetary spacecraft will slingshot around Earth in the super early morning hours. The spacecraft, a joint European and Japanese creation, will use our planet’s gravity to brake its speed and change its course through the Solar System, putting itself on track to reach Mercury in the next five years.

The probe whipping by our planet is called BepiColombo, which is actually two spacecraft wrapped into one package. One spacecraft, designed and operated by the European Space Agency, is equipped with 11 instruments to study Mercury from the planet’s orbit. The second comes from the Japanese Aerospace Exploration Agency (JAXA), and it’s designed to study Mercury while spinning in orbit. Once they reach Mercury, the two spacecraft will break apart and revolve around the planet on their own, studying the world’s exterior and its inner core.

Before all that can happen, BepiColombo needs to make it to Mercury. Launched in October 2018, BepiColombo’s route to the planet is set to last a total of seven years, and a lot of that time is spent slowing down. Because Mercury is so close to the Sun, spacecraft that travel toward the planet are constantly being tugged by our Solar System’s star, causing them to speed up. BepiColombo has to repeatedly put on the brakes to make sure it doesn’t go barreling into the Sun.

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As authorities enforce social distancing in the battle against coronavirus, don’t be surprised if you hear reminders coming from the sky.

Police departments in Florida and New Jersey have drones with pre-recorded warnings that will be deployed if crowds are not following COVID-19 guidelines.

Ahhhhhh, these people scare me, more than the Virus.

Clearview AI, which has alarmed privacy experts, hired several far-right employees, a HuffPost investigation found.

Worth having a look, who knows.

Cytokines and chemokines are thought to play an important role in immunity and immunopathology during virus infections [3]. Patients with severe COVID-19 have higher serum levels of pro-inflammatory cytokines (TNF-α, IL-1 and IL-6) and chemokines (IL-8) compared to individuals with mild disease or healthy controls, similar to patients with SARS or MERS. The change of laboratory parameters, including elevated serum cytokine, chemokine levels, and increased NLR in infected patients are correlated with the severity of the disease and adverse outcome, suggesting a possible role for hyper-inflammatory responses in COVID-19 pathogenesis. Importantly, previous studies showed that viroporin E, a component of SARS-associated coronavirus (SARS-CoV), forms Ca2C-permeable ion channels and activates the NLRP3 inflammasome. In addition, another viroporin 3a was found to induce NLRP3 inflammasome activation. The mechanisms are unclear.

Colchicine, an old drug used in auto-inflammatory disorders (i.e., Familiar Mediterranean Fever and Bechet disease) and in gout, counteracts the assembly of the NLRP3 inflammasome, thereby reducing the release of IL-1b and an array of other interleukins, including IL-6, that are formed in response to danger signals. Recently, colchicine has been successfully used in two cases of life-threatening post-transplant capillary leak syndrome. These patients had required mechanically ventilation for weeks and hemodialysis, before receiving colchicine, which abruptly restored normal respiratory function and diuresis over 48 hrs [4].

Continue reading “Colchicine Efficacy in COVID-19 Pneumonia” »

The Milky Way in the sky of Ali Prefecture, southwest China’s Tibet Autonomous Region, Sept.27, 2018. (Xinhua/Purbu Zhaxi)

The star, named LAMOST J040643.69+542347.8, has an estimated rotational velocity of 540 km per second, which is about 100 km per second faster than that of the previous record holder, HD 191423.

BEIJING, April 9 (Xinhua) — A Chinese astronomer has discovered the fastest rotating star in the Milky Way galaxy based on data from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) located in Xinglong, in northern China’s Hebei Province.

This is a good one pass it on

This study aimed to explore whether the therapeutic effects of EPO rely on the suppression of the NLRP3 inflammasome and the specific mechanisms in an LPS-induced ALI mouse model. ALI was induced in C57BL/6 mice by intraperitoneal (i.p.) injection of LPS (15 mg/kg). EPO was administered intraperitoneally at 5 U/g after LPS challenge. The mice were sacrificed 8 h later. Our findings indicated that application of EPO markedly diminished LPS-induced lung injury by restoring histopathological changes, lessened lung wet/dry (W/D) ratio, protein concentrations in bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) levels. Meanwhile, EPO evidently decreased interleukin-1β (IL-1β) and interleukin-18 (IL-18) secretion, the expression of NLRP3 inflammasome components including pro-IL-1β, NLRP3, and cleaved caspase-1 as well as phosphorylation of nuclear factor-κB (NF-κB) p65, which may be associated with activation of EPO receptor (EPOR), phosphorylation of Janus-tyrosine kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3)

Taken together, this study indicates that EPO can effectively attenuate LPS-induced lung injury in mice by suppressing the NLRP3 inflammasome, which is dependent upon activation of EPOR/JAK2/STAT3 signaling and inhibition of the NF-κB pathway.

Continue reading “Suppression of NLRP3 Inflammasome” »

Even before the coronavirus, air pollution killed seven million people a year. Will today’s cleaner air inspire us to do better?