Lifeboat Foundation

Salamanders and lizards can regrow limbs. Certain worms and other creatures can generate just about any lost part — including a head — and the latest genetics research on body part regeneration is encouraging.

Since they are adult stem cells that have reverted back to a less developed — more pluripotent — state, iPSCs remind scientists of the stem cells that enable lizards to regrow limbs, and zebrafish to regrow hearts. When it comes to limbs, the understanding the regrowth process could help scientists promote nerve regeneration in cases when a limb is severely damaged, but not physically lost. Nerves of the human peripheral nervous system do have the ability to regrow, but whether this actually happens depends on the extent of the injury, so understanding the stem cell physiology in zebrafish and other animals could help clinicians fill the gap. The knowledge gained also could impact development of treatments aimed at promoting nerve regrowth in the central nervous system, for instance in the spinal cord after an injury.

Continue reading “Body part regeneration: How science can make the jump from fantasy to reality” »

Your phone’s GPS, the Wi-Fi in your house and communications on aircraft are all powered by radio-frequency, or RF, waves, which carry information from a transmitter at one point to a sensor at another. The sensors interpret this information in different ways. For example, a GPS sensor uses the angle at which it receives an RF wave to determine its own relative location. The more precisely it can measure the angle, the more accurately it can determine location.

In a new paper published in Physical Review Letters, University of Arizona engineering and optical sciences researchers, in collaboration with engineers from General Dynamics Mission Systems, demonstrate how a combination of two techniques—radio frequency photonics sensing and quantum metrology—can give sensor networks a previously unheard-of level of precision. The work involves transferring information from electrons to photons, then using quantum entanglement to increase the photons’ sensing capabilities.

“This quantum sensing paradigm could create opportunities to improve GPS systems, astronomy laboratories and biomedical imaging capabilities,” said Zheshen Zhang, assistant professor of materials science and engineering and optical sciences, and principal investigator of the university’s Quantum Information and Materials Group. “It could be used to improve the performance of any application that requires a network of sensors.”

Compared to a conventional computer, this device has a learning capability that is not software-based.

The star itself is about the same mass and a little larger than the Sun — a minority in our exoplanet hunts. It’s orbited by six planets: a super-Earth and five mini-Neptunes.

After monitoring it for seven years, astronomers have discovered that all six of those planets are orbiting HD 158259 in almost perfect orbital resonance. This discovery could help us to better understand the mechanisms of planetary system formation, and how they end up in the configurations we see.

https://youtube.com/watch?v=LBVYcLi1gSM

Ladies Monday with ReallyGraceful going a bit further into Bill Gates.

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A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer.

The discovery marks a critical step toward developing a potential new class of anti–cancer drugs that enhance the activity of a prevalent family of tumor suppressor proteins, the authors say.

The findings, which appear in the leading life sciences journal Cell, are less a story of what than how.

Multiple sclerosis (MS) is known as “the disease with a thousand faces” because symptoms and progression can vary dramatically from patient to patient. But every MS patient has one thing in common: Cells of their body’s own immune system migrate to the brain, where they destroy the myelin sheath—the protective outer layer of the nerve fibers. As a result, an electrical short circuit occurs, preventing the nerve signals from being transmitted properly.

Many MS medications impair immune memory

Researchers don’t yet know exactly which immune cells are involved in stripping away the myelin sheath. Autoreactive T and B cells, which wrongly identify the myelin sheath as a foreign body, travel to the brain and initiate the disease. “Up until now, MS drugs have essentially targeted these T and B cells, both of which are part of the acquired immune system,” says Dr. Alexander Mildner, a scientist at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the senior author of the paper now published in Nature Immunology.

New psychology study shows that some people have increased brain sensitivity for “aha moments”.

The researchers scanned brains of participants and noticed orgasm-like signals during insights.

The scientists think this evolutionary adaptation drives creation of science and culture.

Continue reading “Insightful ideas can trigger orgasmic brain signals, finds study” »

Only 10 years ago, scientists working on what they hoped would open a new frontier of neuromorphic computing could only dream of a device using miniature tools called memristors that would function/operate like real brain synapses.

But now a team at the University of Massachusetts Amherst has discovered, while on their way to better understanding protein nanowires, how to use these biological, electricity conducting filaments to make a neuromorphic memristor, or “memory transistor,” device. It runs extremely efficiently on very low power, as brains do, to carry signals between neurons. Details are in Nature Communications.

As first author Tianda Fu, a Ph.D. candidate in electrical and computer engineering, explains, one of the biggest hurdles to neuromorphic computing, and one that made it seem unreachable, is that most conventional computers operate at over 1 volt, while the brain sends signals called action potentials between neurons at around 80 millivolts—many times lower. Today, a decade after early experiments, memristor voltage has been achieved in the range similar to conventional computer, but getting below that seemed improbable, he adds.