Lifeboat Foundation

Advances in quantum computation for electronic structure, and particularly heuristic quantum algorithms, create an ongoing need to characterize the performance and limitations of these methods. Here we discuss some potential pitfalls connected with the use of hardware-efficient Ansätze in variational quantum simulations of electronic structure. We illustrate that hardware-efficient Ansätze may break Hamiltonian symmetries and yield nondifferentiable potential energy curves, in addition to the well-known difficulty of optimizing variational parameters. We discuss the interplay between these limitations by carrying out a comparative analysis of hardware-efficient Ansätze versus unitary coupled cluster and full configuration interaction, and of second-and first-quantization strategies to encode Fermionic degrees of freedom to qubits.

Computer simulations of a human brain under the influence of LSD show that entropy increases the most in regions responsible for processing vision and integrating sensory information.

By Karmela Padavic-Callaghan

The quest to understand quantum mechanics has led to remarkable technological advancements, granting us power and control over the natural world. However, despite these successes, the paradoxes and mysteries surrounding the theory continue to challenge our understanding of reality. This raises the question of whether science, particularly quantum mechanics, provides us with true comprehension of the world or merely equips us with power without deeper understanding, writes John Horgan.

The potential of satellite-based synthetic biology and genetic engineering to revolutionize healthcare is becoming increasingly clear. Recent advances in the field have opened up a world of possibilities for medical professionals and researchers, allowing them to diagnose and treat diseases more effectively and efficiently than ever before.

Satellite-based synthetic biology and genetic engineering have already been used to develop treatments for a variety of conditions, including cancer, heart disease, and neurological disorders. By using satellite-based techniques, researchers can quickly and accurately identify genetic mutations and other abnormalities in a patient’s DNA. This allows them to develop personalized treatments that are tailored to the individual’s specific needs.

The use of satellite-based synthetic biology and genetic engineering also has the potential to reduce healthcare costs. By identifying genetic mutations and other abnormalities at an early stage, doctors can avoid costly and unnecessary treatments. This could lead to significant savings for both patients and healthcare providers.

To test this idea, the researchers studied the conditions of the extremely early universe. When our cosmos was very young, it was also small, hot and dense. In that youthful cosmos, all forms of matter and energy were ramped up to unimaginable scales, far greater than even our most powerful particle colliders are capable of achieving.

The researchers found that in this setup, gravitational waves — ripples in the fabric of space-time generated by collisions between the most massive cosmic objects — play an important role. Normally, gravitational waves are exceedingly weak, capable of nudging an atom through a distance less than the width of its own nucleus. But in the early universe, the waves could have been much stronger, and that could have seriously influenced everything else.

Those early waves would have sloshed back and forth, amplifying themselves. Anything else in the universe would have gotten caught up in the push and pull of the waves, leading to a resonance effect. Like a kid pumping their legs at just the right time to send a swing higher and higher, the gravitational waves would have acted as a pump, driving matter into tight clumps over and over again.

Summary: Experts see a bright future in the complementary use of artificial intelligence (AI) and structure-based drug discovery for drug discovery. Researchers explain how computational methods will streamline drug discovery by predicting which drug molecules are most likely to bind with the target receptor. The structure-based and AI-based approaches complement each other and can save time and money while yielding better results than traditional trial-and-error methods.

Source: USC

Artificial intelligence can generate poems and essays, create responsive game characters, analyze vast amounts of data and detect patterns that the human eye might miss. Imagine what AI could do for drug discovery, traditionally a time-consuming, expensive process from the bench to the bedside.

Chronic anxiety is prevalent and associated with an increased risk of cardiovascular disease. Prior studies that have reported a relationship between muscle sympathetic nerve activity (MSNA) and anxiety have focused on participants with anxiety disorders and/or metabolic syndrome. The present study leverages a large cohort of healthy adults devoid of cardiometabolic disorders to examine the hypothesis that trait anxiety severity is positively associated with resting MSNA and blood pressure. Resting blood pressure (BP) (sphygmomanometer and finger plethysmography), MSNA (microneurography), and heart rate (HR; electrocardiogram) were collected in 88 healthy participants (52 males, 36 females, 25 ± 1 yr, 25 ± 1 kg/m²). Multiple linear regression was performed to assess the independent relationship between trait anxiety, MSNA, resting BP, and HR while controlling for age and sex. Trait anxiety was significantly correlated with systolic arterial pressure (SAP; r = 0.251, P = 0.018), diastolic arterial pressure (DAP; r = 0.291, P = 0.006), mean arterial pressure (MAP; r = 0.328, P = 0.002), MSNA burst frequency (BF; r = 0.237, P = 0.026), and MSNA burst incidence (BI; r = 0.225, P = 0.035). When controlling for the effects of age and sex, trait anxiety was independently associated with SAP (β = 0.206, P = 0.028), DAP (β = 0.317, P = 0.002), MAP (β = 0.325, P = 0.001), MSNA BF (β = 0.227, P = 0.030), and MSNA BI (β = 0.214, P = 0.038). Trait anxiety is associated with increased blood pressure and MSNA, demonstrating an important relationship between anxiety and autonomic blood pressure regulation.

NEW & NOTEWORTHY Anxiety is associated with development of cardiovascular disease. Although the sympathetic nervous system is a likely mediator of this relationship, populations with chronic anxiety have shown little, if any, alteration in resting levels of directly recorded muscle sympathetic nerve activity (MSNA). The present study is the first to reveal an independent relationship between trait anxiety, resting blood pressure, and MSNA in a large cohort of healthy males and females devoid of cardiometabolic comorbidities.

Listen to this article’s corresponding podcast at https://ajpheart.podbean.com/e/anxiety-and-muscle-sympathetic-nerve-activity/.

A recent study published in Current Biology provides evidence that people suffering from nightmare disorder can experience an acceleration in the remission of their symptoms when treated with behavioral therapy and Targeted Memory Reactivation.

Nightmare disorder (ND) is a condition characterized by recurrent nightmares that significantly affect daytime functioning. Imagery Rehearsal Therapy (IRT) is the most recommended treatment for ND, whereby patients imagine a more positive outcome for their nightmare, and then recall the new dream. However, “approximately 30% of patients are unresponsive to this treatment,” the authors of the new study explained.

A growing body of evidence indicates that Rapid Eye Movement (REM) sleep can aid in decreasing negative emotions and consolidating the recall of positive emotional memories. With this in mind, the authors sought to investigate whether manipulating memory processing during REM could accelerate the remission of ND when combined with Imagery Rehearsal Therapy.

The Dark Tetrad personality traits of sadism, narcissism, psychopathy, and Machiavellianism have long been associated with perpetrating negative behavior, but can they also put someone at higher risk for victimization? A study published in Frontiers in Psychology suggest that these traits may be associated with higher rates of being the victim of bullying.

Bullying is a serious and pervasive problem that can be associated with many negative outcomes for victims, including depression, anxiety, substance use, and even suicidality. Due to these potentially grave outcomes, research has attempted to delve into the dynamics surrounding bullying, including what makes people more likely to become a perpetrator and/or a victim of bullying.

The Dark Tetrad traits are typically linked with antisocial and criminal behaviors. They are personality traits that are frequently associated with a lack of empathy, increased manipulation, and a disregard for other people.