Lifeboat Foundation

Paper published in Molecules (ISSN 1420–3049) discusses the efficient delivery of curcumin, a well-known anti-inflammatory antioxidant, as a potential candidate for glioblastoma (GB) treatment.

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Glioblastoma (GB) is a deadly and aggressive cancer of the CNS. Even with extensive resection and chemoradiotherapy, patient survival is still only 15 months. To maintain growth and proliferation, cancer cells require a high oxidative state. Curcumin, a well-known anti-inflammatory antioxidant, is a potential candidate for treatment of GB. To facilitate efficient delivery of therapeutic doses of curcumin into cells, we encapsulated the drug in surface-modified polyamidoamine (PAMAM) dendrimers. We studied the in vitro effectiveness of a traditional PAMAM dendrimer (100% amine surface, G4 NH2), surface-modified dendrimer (10% amine and 90% hydroxyl-G4 90/10-Cys), and curcumin (Cur)-encapsulated dendrimer (G4 90/10-Cys-Cur) on three species of glioblastoma cell lines: mouse-GL261, rat-F98, and human-U87.

AI is quickly becoming an essential part of daily work. It’s already being used to help improve operational processes, strengthen customer service, measure employee experience, and bolster cybersecurity efforts, among other applications. And with AI deepening its presence in daily life, as more people turn to AI bot services, such as ChatGPT, to answer questions and get help with tasks, its presence in the workplace will only accelerate.

Much of the discussion around AI in the workplace has been about the jobs it could replace. It’s also sparked conversations around ethics, compliance, and governance issues, with many companies taking a cautious approach to adopting AI technologies and IT leaders debating the best path forward.

While the full promise of AI is still uncertain, it’s early impact on the workplace can’t be ignored. It’s clear that AI will make its mark on every industry in the coming years, and it’s already creating a shift in demand for skills employers are looking for. AI has also sparked renewed interest in long-held IT skills, while creating entirely new roles and skills companies will need to adopt to successfully embrace AI.

SpaceX’s Starlink satellite internet constellation continues to deliver stunning download speeds in Germany. The network, comprised of thousands of satellites, became well known all over for its remarkable download speeds soon after it was opened for public participation. However, the hype around Starlink, the world’s first commercially successful low Earth orbit (LEO) satellite internet, led to millions of users signing up for SpaceX’s service — faster than SpaceX could add capacity. This led to performance downgrades across areas of high demand, particularly in several regions of America. However, now and then, Starlink reminds everyone of its true potential, and that’s the case with today’s internet tests.

Starlink Crosses 500 Mbps In Multiple Download Speed Tests

Today’s test comes courtesy of a Reddit user who recently received their Starlink user terminal after moving to rural Germany. Starlink tests in the European country have often produced remarkable results, owning partly due to lesser congestion as well as the placement of satellites. SpaceX is gradually building out its constellation, which eventually aims to be made of thousands of satellites. This leads to unevenly spread out satellites that benefit some areas in the form of higher speeds.

Recently, eSentire TRU reported, Hackers Use Weaponized PDF Files to Attack Manufacturing, Commercial, and Healthcare Organizations.

WASHINGTON — Satellite manufacturer Terran Orbital has signed an agreement with French aerospace giant Safran to explore U.S.-based production of satellite propulsion systems, the companies announced June 23.

Under the agreement, Safran Electronics & Defense and Terran Orbital will investigate opportunities and prerequisites for the production of electric propulsion systems for satellites based on Safran’s PPSX00 plasma thruster.

The PPSX00 is a hall effect plasma thruster, recently introduced by Safran for the low Earth orbit satellite market.

The greatest hazard for humans on deep-space exploration missions is radiation. To protect astronauts venturing out beyond Earth’s protective magnetosphere and sustain a permanent presence on Moon and/or Mars, advanced passive radiation protection is highly sought after. Due to the complex nature of space radiation, there is likely no one-size-fits-all solution to this problem, which is further aggravated by up-mass restrictions. In search of innovative radiation-shields, biotechnology holds unique advantages such as suitability for in-situ resource utilization (ISRU), self-regeneration, and adaptability. Certain fungi thrive in high-radiation environments on Earth, such as the contamination radius of the Chernobyl Nuclear Power Plant. Analogous to photosynthesis, these organisms appear to perform radiosynthesis, using pigments known as melanin to convert gamma-radiation into chemical energy. It is hypothesized that these organisms can be employed as a radiation shield to protect other lifeforms. Here, growth of Cladosporium sphaerospermum and its capability to attenuate ionizing radiation, was studied aboard the International Space Station (ISS) over a time of 30 days, as an analog to habitation on the surface of Mars. At full maturity, radiation beneath a ≈ 1.7 mm thick lawn of the melanized radiotrophic fungus (180° protection radius) was 2.17±0.35% lower as compared to the negative control. Estimations based on linear attenuation coefficients indicated that a ~ 21 cm thick layer of this fungus could largely negate the annual dose-equivalent of the radiation environment on the surface of Mars, whereas only ~ 9 cm would be required with an equimolar mixture of melanin and Martian regolith. Compatible with ISRU, such composites are promising as a means to increase radiation shielding while reducing overall up-mass, as is compulsory for future Mars-missions.

The authors have declared no competing interest.

An investor claims he raised safety concerns to the CEO of OceanGate Expeditions but was met with reassurance.

According to Infosys, the company’s AI-first specialists and data strategists, who are responsible for delivering Infosys Topaz AI-first services, solutions, and platforms, will be part of shaping the curriculum of these courses. Their expertise will ensure that learners are equipped with future-ready skill sets.

Infosys further explains that it will provide certification in AI and Generative AI skills, which are crucial for securing jobs, through its Infosys Springboard Virtual Learning Platform. The certification program will offer a diverse range of courses covering various topics related to AI. These courses include an introductory course on AI and Generative AI, with a specific emphasis on deep learning and natural language processing. Additionally, there will be a masterclass on AI and the impact of Generative AI.

Continue reading “Infosys launches free AI certifications to help people learn skills for AI-related jobs: details here” »

The nucleus is the lightest isotope of astatine discovered to date.