Lifeboat Foundation

In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.

In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.

While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.

The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].

Continue reading “Intimations of Imitations: Visions of Cellular Prosthesis & Functionally-Restorative Medicine” »

1) CERN officially attempted to produce ultraslow miniature black holes on earth. It has announced to continue doing so after the current more than a year-long break for upgrading.

2) Miniature black holes possess radically new properties according to published scientific results that go unchallenged in the literature for 5 years: no Hawking evaporation; unchargedness; invisibility to CERN’s detectors; enhanced chance of being produced.

3) Of the millions of miniature black holes hoped to have been produced, at least one is bound to be slow enough to stay inside earth to circulate there.

4) This miniature black hole circulates undisturbed – until it captures the first charged quark. From then on it grows exponentially doubling in size in months at first, later in weeks.

Continue reading “Update on the LHC-Danger – after Half a Year” »

UPDATE: A generous contribution of $5,000 from the Methuselah Foundation has been received! This will put the fundraiser over the top of the cost and pay for the advanced Champions Oncology treatment described below.

However, Dr. Coles still has other medical expenses outstanding, and more will be coming in.

To cover these as well as Dr. Coles’s many other personal expenses, the fundraiser will now have an extended timeframe and the limit has been raised to $20,000.

We are currently at $13,385 of our 20,000 goal! Help us make it all the way!

Continue reading “Methuselah Foundation Just Donated $5,000 to L. Stephen Coles Fundraiser — Please Support This Campaign To Save A Life” »

The recent scandal involving the surveillance of the Associated Press and Fox News by the United States Justice Department has focused attention on the erosion of privacy and freedom of speech in recent years. But before we simply attribute these events to the ethical failings of Attorney General Eric Holder and his staff, we also should consider the technological revolution powering this incident, and thousands like it. It would appear that bureaucrats simply are seduced by the ease with which information can be gathered and manipulated. At the rate that technologies for the collection and fabrication of information are evolving, what is now available to law enforcement and intelligence agencies in the United States, and around the world, will soon be available to individuals and small groups.

We must come to terms with the current information revolution and take the first steps to form global institutions that will assure that our society, and our governments, can continue to function through this chaotic and disconcerting period. The exponential increase in the power of computers will mean that changes the go far beyond the limits of slow-moving human government. We will need to build new institutions to the crisis that are substantial and long-term. It will not be a matter that can be solved by adding a new division to Homeland Security or Google.

We do not have any choice. To make light of the crisis means allowing shadowy organizations to usurp for themselves immense power through the collection and distortion of information. Failure to keep up with technological change in an institutional sense will mean that in the future government will be at best a symbolic façade of authority with little authority or capacity to respond to the threats of information manipulation. In the worst case scenario, corporations and government agencies could degenerate into warring factions, a new form of feudalism in which invisible forces use their control of information to wage murky wars for global domination.

No degree of moral propriety among public servants, or corporate leaders, can stop the explosion of spying and the propagation of false information that we will witness over the next decade. The most significant factor behind this development will be Moore’s Law which stipulates that the number of microprocessors that can be placed economically on a chip will double every 18 months (and the cost of storage has halved every 14 months) — and not the moral decline of citizens. This exponential increase in our capability to gather, store, share, alter and fabricate information of every form will offer tremendous opportunities for the development of new technologies. But the rate of change of computational power is so much faster than the rate at which human institutions can adapt — let alone the rate at which the human species evolves — that we will face devastating existential challenges to human civilization.

Continue reading “The Impending Crisis of Data: Do We Need a Constitution of Information?” »

Prologue:

‘Let there be light,’ said the Cgi-God, and there was light…and God Rays.

We were out in the desert; barren land, and our wish was that it be transformed into a green oasis; a tropical paradise.

Continue reading “Recreating Heaven and Earth...in real-time.” »

*** PLEASE alert your friends—Our own continued health and longevity may depend on Steve continuing his work.***

This call for support was also posted by Ilia Stambler on the Longevity Alliance Website, and organized on YouCaring.com by John M. Adams. Eric Schulke has also helped tremendously in spreading the word about the Fundraiser.

Since founding the Los Angeles Gerontology Research Group in 1990, Dr. L. Stephen Coles M.D., Ph.D., has worked tirelessly to develop new ways to slow and ultimately reverse human aging.

Everyone active in the LA-GRG or the Worldwide GRG Discussion Group have benefited from his expertise. His continual reporting of news about the latest developments to the List and his work in areas such as gathering blood samples for a complete genome analysis of the oldest people in the world (supercentenarians, aged 110+) is ground breaking and far ahead of anything that has ever been accomplished before. Publication of this work is expected in collaboration with Stanford University before the end of the year. Other accomplishments are equally notable

Continue reading “Stephen L. Coles is DYING and NEEDS your Help!” »

By Avi Roy, University of Buckingham

In rich countries, more than 80% of the population today will survive past the age of 70. About 150 years ago, only 20% did. In all this while, though, only one person lived beyond the age of 120. This has led experts to believe that there may be a limit to how long humans can live.

Animals display an astounding variety of maximum lifespan ranging from mayflies and gastrotrichs, which live for 2 to 3 days, to giant tortoises and bowhead whales, which can live to 200 years. The record for the longest living animal belongs to the quahog clam, which can live for more than 400 years.

If we look beyond the animal kingdom, among plants the giant sequoia lives past 3000 years, and bristlecone pines reach 5000 years. The record for the longest living plant belongs to the Mediterranean tapeweed, which has been found in a flourishing colony estimated at 100,000 years old.

Continue reading “Lust for life: breaking the 120-year barrier in human ageing” »

This essay was originally published by the Institute for Ethics & Emerging Technologies

One of the most common anti-Transhumanist tropes one finds recurring throughout Transhumanist rhetoric is our supposedly rampant hubris. Hubris is an ancient Greek concept meaning excess of pride that carries connotations of reckless vanity and heedless self-absorbment, often to the point of carelessly endangering the welfare of others in the process. It paints us in a selfish and dangerous light, as though we were striving for the technological betterment of ourselves alone and the improvement of the human condition solely as it pertains to ourselves, so as to be enhanced relative to the majority of humanity.

In no way is this correct or even salient. I, and the majority of Transhumanists, Techno-Progressives and emerging-tech-enthusiasts I would claim, work toward promoting beneficial outcomes and deliberating the repercussions and most desirable embodiments of radically-transformative technologies for the betterment of all mankind first and foremost, and only secondly for ourselves if at all.

The ired irony of this situation is that the very group who most often hails the charge of Hubris against the Transhumanist community is, according to the logic of hubris, more hubristic than those they rail their charge against. Bio-Luddites, and more generally Neo-Luddites, can be clearly seen to be more self-absorbed and recklessly-selfish than the Transhumanists they are so quick to raise qualms against.

Continue reading “The Hubris of Neo-Luddism” »

The following article was originally published by Immortal Life

When asked what the biggest bottleneck for Radical or Indefinite Longevity is, most thinkers say funding. Some say the biggest bottleneck is breakthroughs and others say it’s our way of approaching the problem (i.e. that we’re seeking healthy life extension whereas we should be seeking more comprehensive methods of indefinite life-extension), but the majority seem to feel that what is really needed is adequate funding to plug away at developing and experimentally-verifying the various, sometimes mutually-exclusive technologies and methodologies that have already been proposed. I claim that Radical Longevity’s biggest bottleneck is not funding, but advocacy.

This is because the final objective of increased funding for Radical Longevity and Life Extension research can be more effectively and efficiently achieved through public advocacy for Radical Life Extension than it can by direct funding or direct research, per unit of time or effort. Research and development obviously still need to be done, but an increase in researchers needs an increase in funding, and an increase in funding needs an increase in the public perception of RLE’s feasibility and desirability.

There is no definitive timespan that it will take to achieve indefinitely-extended life. How long it takes to achieve Radical Longevity is determined by how hard we work at it and how much effort we put into it. More effort means that it will be achieved sooner. And by and large, an increase in effort can be best achieved by an increase in funding, and an increase in funding can be best achieved by an increase in public advocacy. You will likely accelerate the development of Indefinitely-Extended Life, per unit of time or effort, by advocating the desirability, ethicacy and technical feasibility of longer life than you will by doing direct research, or by working towards the objective of directly contributing funds to RLE projects and research initiatives. (more…)