Lifeboat Foundation

Chromatin proteins have expanded the mammalian synthetic biology toolbox by enabling control of active and silenced states at endogenous genes. Others have reported synthetic proteins that bind DNA and regulate genes by altering chromatin marks, such as histone modifications. Previously we reported the first synthetic transcriptional activator, the “Polycomb-based transcription factor” (PcTF), that reads histone modifications through a protein-protein interaction between the PCD motif and trimethylated lysine 27 of histone H3 (H3K27me3). Here, we describe the genome-wide behavior of PcTF. Transcriptome and chromatin profiling revealed PcTF-sensitive promoter regions marked by proximal PcTF and distal H3K27me3 binding. These results illuminate a mechanism in which PcTF interactions bridge epigenetic marks with the transcription initiation complex. In three cancer-derived human cell lines tested here, many PcTF-sensitive genes encode developmental regulators and tumor suppressors. Thus, PcTF represents a powerful new fusion-protein-based method for cancer research and treatment where silencing marks are translated into direct gene activation.

OAHU, HAWAI’I —(ENEWSPF)–September 1, 2016. As thousands of government representatives and conservationists convene in Oahu this week for the 2016 World Conservation Congress, international conservation and environmental leaders are raising awareness about the potentially dangerous use of gene drives — a controversial new synthetic biology technology intended to deliberately cause targeted species to become extinct.

Members of the International Union for the Conservation of Nature (IUCN), including NGOs, government representatives, and scientific and academic institutions, overwhelmingly voted to adopt a de facto moratorium on supporting or endorsing research into gene drives for conservation or other purposes until the IUCN has fully assessed their impacts. News of the August 26 digital vote comes as an important open letter to the group is being delivered.

Scientists and environmental experts and organizations from around the globe have advocated for a halt to proposals for the use of gene drive technologies in conservation. Announced today, a long list of environmental leaders, including Dr. Jane Goodall, DBE, genetics professor and broadcaster Dr. David Suzuki, Dr. Fritjof Capra, entomologist Dr. Angelika Hilbeck, Indian environmental activist Dr. Vandana Shiva and organic pioneer and biologist Nell Newman, have lent their support to the open letter: “A Call for Conservation with a Conscience: No Place for Gene Drives in Conservation.” The letter states, in part: “Gene drives, which have not been tested for unintended consequences, nor fully evaluated for ethical and social impacts, should not be promoted as conservation tools.”

For all my tree loving friends.

A University of Canterbury professor is researching ways we can 3D print wood. Could this be how we save our trees?

My friends at ORN setting records again.

Researchers at the Oak Ridge National Laboratory broke a world record for the largest solid 3D-printed item with its trim-and-drill tool. The item, which is practically the size of a large SUV, took 30 hours to print using carbon fiber and composite plastic materials.

Continue reading “Oak Ridge Just Entered Record Books With The Largest 3D-Printed Object in the World” »

Art 3D style.

See what some talented artists have created using C4D R18 – from sci-fi art a very real-looking Rolleiflex.

Latest article chronicling my entrepreneurial journey and how anyone can be successful and change the world. You need only look at the Lifeboat Foundation to see that entrepreneurs can turn their wealth into instigators for change!

YawLife is an embodiment of my life… All of my struggles, all of my mistakes, all of my pain, and all of my perseverance through in-fortitude to reach the pinnacle I’m at now, where the fruits of my labour are finally beginning to flourish, and where the seeds sowed in the past have begun to grown roots, which shall outlast even my own passing. To me, YawLife is not about just building a company and selling instantaneously. It’s about endowing my life’s work to make it successful. To reward those who believed in me early once I’ve succeeded, to reward the world for their choice to use our service, and to reward myself with, at the very least, the pride in creating something from nothing… Because, to do such a thing, is not a simple task. You can try as much as possible, and for all that effort, nothing may arise from it, but…

It is in the journey of creation that brings true elation to one’s soul — an inner fulfilment beyond what any odd job or person can spark within.

Continue reading “How You Discover the Passion to Pursue Entrepreneurship” »

“Fifty years after the show aired, Star Trek’s fictional tricorder is far from becoming a reality. But a $10 million prize from the XPRIZE Foundation is hoping to motivate inventors to create one quickly.”

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Google’s new QC targeted by the end of next year.

Researchers at the company could unveil a quantum computer that is superior to conventional computers by the end of next year.

Luv this.

A research team led by Professor Keon Jae Lee from the Korea Advanced Institute of Science and Technology (KAIST) and by Dr. Jae-Hyun Kim from the Korea Institute of Machinery and Materials (KIMM) has jointly developed a continuous roll-processing technology that transfers and packages flexible large-scale integrated circuits (LSI), the key element in constructing the computer’s brain such as CPU, on plastics to realize flexible electronics.

Professor Lee previously demonstrated the silicon-based flexible LSIs using 0.18 CMOS (complementary metal -oxide semiconductor) process in 2013 (ACS Nano, “In Vivo Silicon-based Flexible Radio Frequency Integrated Circuits Monolithically Encapsulated with Biocompatible Liquid Crystal Polymers”) and presented the work in an invited talk of 2015 International Electron Device Meeting (IEDM), the world’s premier semiconductor forum.

Continue reading “Continuous Roll-process Technology for Transferring and Packaging Flexible Large-scale Integrated Circuits” »