Lifeboat Foundation

ERCC1 (excision repair cross complementing‐group 1) is a mammalian endonuclease that incises the damaged strand of DNA during nucleotide excision repair and interstrand cross‐link repair. Ercc1^−/Δ mice, carrying one null and one hypomorphic Ercc1 allele, have been widely used to study aging due to accelerated aging phenotypes in numerous organs and their shortened lifespan. Ercc1^−/Δ mice display combined features of human progeroid and cancer‐prone syndromes. Although several studies report cellular senescence and apoptosis associated with the premature aging of Ercc1^−/Δ mice, the link between these two processes and their physiological relevance in the phenotypes of Ercc1^−/Δ mice are incompletely understood. Here, we show that ERCC1 depletion, both in cultured human fibroblasts and the skin of Ercc1^−/Δ mice, initially induces cellular senescence and, importantly, increased expression of several SASP (senescence‐associated secretory phenotype) factors. Cellular senescence induced by ERCC1 deficiency was dependent on activity of the p53 tumor‐suppressor protein. In turn, TNFα secreted by senescent cells induced apoptosis, not only in neighboring ERCC1‐deficient nonsenescent cells, but also cell autonomously in the senescent cells themselves. In addition, expression of the stem cell markers p63 and Lgr6 was significantly decreased in Ercc1^−/Δ mouse skin, where the apoptotic cells are localized, compared to age‐matched wild‐type skin, possibly due to the apoptosis of stem cells. These data suggest that ERCC1‐depleted cells become susceptible to apoptosis via TNFα secreted from neighboring senescent cells. We speculate that parts of the premature aging phenotypes and shortened health‐ or lifespan may be due to stem cell depletion through apoptosis promoted by senescent cells.

Last week, the transhumanist activist Zoltan Istvan announced his candidacy for President of the United States in next year’s elections. The writer, humanitarian and outspoken advocate of radical science is no stranger to the issues surrounding Longevity, and has spoken widely on subjects including AI, genetic editing, technology policy, and futurism.

In 2016, Istvan ran as an independent presidential candidate and travelled across the United States, spreading his message from a coffin-shaped bus, known as the “Immortality Bus.” This time he’s on the ballot, running against Donald Trump as a candidate for the Republican party in next year’s primaries. Things are a bit more serious this time.

Among his key policies, Istvan includes transhumanism, universal basic income and the need to beat China in the global innovation race – an issue we addressed in our Jamie Metzl interview. We spoke to him to find out more about his views on the Longevity sector.

Recently world-renowned theoretical physicist, Doctor Michio Kaku, sat down for an interview with world-renowned artificial intelligence Doctor Ray Kurzweil, to talk about The Singularity; who is at the forefront of artificial intelligence and robotics.

The two geniuses talked about how soon computer intelligence will soon surpass us and the possible outcomes of this.

What if developing a 3D gaming world were as easy as snapping pics with your phone? Nvidia researchers recently developed an AI system capable of predicting a complete 3D model from any 2D image.

Called “DIB-R,” the AI takes a picture of any 2D object – an image of a bird, for example – and predicts what it would look like in three dimensions. This prediction includes lighting, texture, and depth.

CAPE CANAVERAL, FLA. — SpaceX made an early holiday delivery to the International Space Station on Sunday, bringing muscle-bound “mighty mice,” pest-killing worms and a smart, empathetic robot.

The station commander, Italy’s Luca Parmitano, used a large robot arm to grab onto the Dragon three days after its launch from Cape Canaveral. The two spacecraft soared 260 miles (420 kilometres) above the South Pacific at the time of capture.

“Whenever we welcome a new vehicle on board, we take on board also a little bit of the soul of everybody that contributed to the project, so welcome on board,” Parmitano told Mission Control.

Two of SA’s most promising female technology entrepreneurs have this year raised millions from astute local and international investors for their global-impact businesses in healthcare and space.

Presagen, co-founded by Dr Michelle Perugini, raised a total of $4.5 million from Jungle Capital group in Australia and US private investor 3Lines Venture Capital, with the SA Government also pitching in.

The funding will help commercialise its Life Whisperer artificial intelligence (AI) platform. Life Whisperer uses AI to identify healthy embryos in in-vitro fertilisation (IVF) with the aim of improving pregnancy outcomes for infertile couples globally.

NASA has tentative plans for a manned mission to Mars sometime in the 2030s. Between now and then, there’s still much that needs to be sorted. To start, massive dust storms, high levels of radiation, low temperatures and a lack of water make the Martian surface an unfriendly place for long-term visits. Taming it for human life will likely prove one of the most demanding and complex engineering puzzles in human history. With those extraordinary obstacles in mind, in 2015 NASA announced the 3D-Printed Habitat Challenge: an open call asking designers and architects outside the traditional aerospace industry to create plans for Martian living centred around 3D printing. One of 10 finalists announced in 2019, this plan from the design practices HASSELL and Eckersley O’Callaghan envisions teams of 3D-printing robots building a protective shield on the Martian surface several months in advance of a human landing. Upon arrival, astronauts would then work alongside the autonomous robots to piece together an inflatable, modular habitat.

Video by LightField London.

I am in shock… Google suddenly as yahoo are allowing conjecture and mendacity be seen as public or scientific opinion. Here is another confused mind who towards the end of her rant quotes Christian scripture as basis to stop Life extension-Transhumanism???

When I say to these minds Behold the leader of Christianity stood for Life abundant-Super Longevity and I can prove such. No matter what lost evangelist or preacher tells you Jesus was a medical researcher of extraordinary magnitude…

NOW BEHOLD THE LOST in this article… https://www.rodofironministries.com/…/transhumanism-and-imm… Respect r.p.berry & AEWR wherein aging now ends we have found the many causes of aging and we have located an expensive cure. We search for partners-investors to now join us in agings end… gerevivify.blogspot.com/

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As jobs are automated out of existence, the division between the very wealthy and the very poor will grow — and any notion of a comfortable middle class will vanish.

That’s according to Roey Tzezana, a future studies researcher at Israel’s Tel Aviv University, according to Haaretz. That stands in contrast to the common argument that new jobs will emerge as others vanish, painting a grim picture for the workforce and global economy.