Lifeboat Foundation

Some problems of the very intuitive evolutionary emergentist paradigm trying to explain consciousness from neurons, thanks to Andrés Gómez Emilsson and Chris Percy at Qualia Research Institute:

The “Slicing Problem” is a thought experiment that raises questions for substrate-neutral computational theories of consciousness, particularly, in functionalist approaches.

The thought experiment uses water-based logic gates to construct a computer in a way that permits cleanly slicing each gate and connection in half, creating two identical computers each instantiating the same computation. The slicing can be reversed and repeated via an on/off switch, without changing the amount of matter in the system.

Dementia has become rampant among human beings who are pushed into a deep mental abyss, devoid of memories and remembrance.

It has been termed as “the long goodbye”. Even though the person remains alive, memories fade away slowly and irreversibly due to dementia.

Dementia eventually snatches away the ability of a person to communicate, eat and drink on their own, recognise family members and understand where they are.

Now that’s Wonderful. It’s touching by how they were brought to tears in making progress in fighting neurogenitive disease.

Auckland scientists are celebrating an important breakthrough after zeroing in on a rare genetic mutation causing motor neuron disease. Their work is now being published in the journal Brain, and national correspondent Amanda Gillies spoke to the lead researcher. ➡️ SUBSCRIBE: https://bit.ly/NewshubYouTube.

Continue reading “‘Whole room was in tears’: NZ scientists see major breakthrough for motor neurone disease | Newshub” »

Safer, more targeted electromagnetic treatment can bring faster, longer-lasting relief for people with depression.

Year 2013 face_with_colon_three

Scientists at Oregon Health & Science University and the Oregon National Primate Research Center (ONPRC) have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body. It is believed that stem cell therapies hold the promise of replacing cells damaged through injury or illness. Diseases or conditions that might be treated through stem cell therapy include Parkinson’s disease, multiple sclerosis, cardiac disease and spinal cord injuries.

The research breakthrough, led by Shoukhrat Mitalipov, Ph.D., a senior scientist at ONPRC, follows previous success in transforming monkey skin cells into embryonic stem cells in 2007. This latest research will be published in the journal Cell online May 15 and in print June 6.

The technique used by Drs. Mitalipov, Paula Amato, M.D., and their colleagues in OHSU’s Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, is a variation of a commonly used method called somatic cell nuclear transfer, or SCNT. It involves transplanting the nucleus of one cell, containing an individual’s DNA, into an egg cell that has had its genetic material removed. The unfertilized egg cell then develops and eventually produces stem cells.

Researchers have discovered that individuals who live to be 100 years old and remain cognitively healthy possess genetic variations that may protect against Alzheimer’s disease. These “protective alleles” are significantly more prevalent among centenarians compared to Alzheimer’s patients and even middle-aged individuals without the disease. This finding could pave the way for new approaches in preventing and treating Alzheimer’s, particularly by focusing on enhancing these protective genetic mechanisms.

The new findings have been published in the journal Alzheimer’s & Dementia.

Alzheimer’s disease is a progressive neurological disorder that predominantly affects older adults, leading to a decline in cognitive functions such as memory and reasoning. Over time, this can result in a complete loss of independence and eventually death. The risk of developing Alzheimer’s increases significantly with age, and while it is not an inevitable part of aging, it is one of the most common causes of dementia among seniors.

A new peptide-carrying magnetic nanoparticle described in Science Advances has resolved both biological and behavioral symptoms in mouse models of Alzheimer’s disease.

A short peptide disassembles stable pathogenic tau fibrils of Alzheimer’s disease.

Researchers at the University of California San Diego have developed a neural implant that provides information about activity deep inside the brain while sitting on its surface. The implant is made up of a thin, transparent and flexible polymer strip that is packed with a dense array of graphene electrodes. The technology, tested in transgenic mice, brings the researchers a step closer to building a minimally invasive brain-computer interface (BCI) that provides high-resolution data about deep neural activity by using recordings from the brain surface.

The work was published on Jan. 11 in Nature Nanotechnology.

“We are expanding the spatial reach of neural recordings with this technology,” said study senior author Duygu Kuzum, a professor in the Department of Electrical and Computer Engineering at the UC San Diego Jacobs School of Engineering. “Even though our implant resides on the brain’s surface, its design goes beyond the limits of physical sensing in that it can infer neural activity from deeper layers.”

Bursts of brain rhythms with “beta” frequencies control where and when neurons in the cortex process sensory information and plan responses. Studying these bursts would improve understanding of cognition and clinical disorders, researchers argue in a new review.

The brain processes information on many scales. Individual cells electrochemically transmit signals in circuits but at the large scale required to produce cognition, millions of cells act in concert, driven by rhythmic signals at varying frequencies. Studying one frequency range in particular, beta rhythms between about 14–30 Hz, holds the key to understanding how the brain controls cognitive processes — or loses control in some disorders — a team of neuroscientists argues in a new review article.

Drawing on experimental data, mathematical modeling and theory, the scientists make the case that bursts of beta rhythms control cognition in the brain by regulating where and when higher gamma frequency waves can coordinate neurons to incorporate new information from the senses or formulate plans of action. Beta bursts, they argue, quickly establish flexible but controlled patterns of neural activity for implementing intentional thought.