Lifeboat Foundation

The new approach has the potential to open a powerful avenue in cellular manipulation. Whereas DNA editing makes permanent changes to the genome of a cell, the CRISPR-based RNA-targeting approach may allow researchers to make temporary changes that can be adjusted up or down, and with greater specificity and functionality than existing methods for RNA interference.

In a study published today in Science, Feng Zhang and colleagues at the Broad Institute and the McGovern Institute for Brain Research at MIT, along with co-authors Eugene Koonin and his colleagues at the NIH, and Konstantin Severinov of Rutgers University-New Brunswick and Skoltech, report the identification and functional characterization of C2c2, an RNA-guided enzyme capable of targeting and degrading RNA.

The findings reveal that C2c2—the first naturally-occurring CRISPR system that targets only RNA to have been identified, discovered by this collaborative group in October 2015—helps protect bacteria against viral infection. They demonstrate that C2c2 can be programmed to cleave particular RNA sequences in bacterial cells, which would make it an important addition to the molecular biology toolbox.

As the computation and communication circuits we build radically miniaturize (i.e. become so low power that 1 picoJoule is sufficient to bang out a bit of information over a wireless transceiver; become so small that 500 square microns of thinned CMOS can hold a reasonable sensor front-end and digital engine), the barrier to introducing these types of interfaces into organisms will get pretty low. Put another way, the rapid pace of computation and communication miniaturization is swiftly blurring the line between the technological base that created us and the technological based we’ve created. Michel Maharbiz, University of California, Berkeley, is giving an overview (june 16, 2016) of recent work in his lab that touches on this concern. Most of the talk will cover their ongoing exploration of the remote control of insects in free flight via implantable radio-equipped miniature neural stimulating systems.; recent results with neural interfaces and extreme miniaturization directions will be discussed. If time permits, he will show recent results building extremely small neural interfaces they call “neural dust,” work done in collaboration with the Carmena, Alon and Rabaey labs.

Radical miniaturization has created the ability to introduce a synthetic neural interface into a complex, multicellular organism, as exemplified by the creation of a “cyborg insect.”

“The rapid pace of computation and communication miniaturization is swiftly blurring the line between technological base we’ve created and the technological base that created us,” explained Dr. Maharbiz. “These combined trends of extreme miniaturization and advanced neural interfaces have enabled us to explore the remote control of insects in free flight via implantable radio-equipped miniature neural stimulating systems.”

Continue reading “Neural Dust — ultra small brain interfaces — is being used to make cyborg insects” »

Walk into any workout facility and, odds are, you’ll see plenty of people working with a personal fitness trainer. It’s common practice to hire a trainer who can help improve your physical fitness, but is it possible to find a trainer for better mental fitness? Entrepreneur Ariel Garten founded her company, InteraXon, around this very idea. Bolstered by new advances in non-invasive brain-machine interfaces (BMIs) that can help people practice ways to reduce stress and improve cognitive abilities, Garten believes this is just the beginning of a lucrative industry.

Garten’s company manufactures a BMI called the Muse, an EEG sensor headband that monitors occipital and temporal brain waves. According to Ariel, the goal of the device is to help people understand their mental processes while at the same time learning to calm and quiet their mind at any time, with the same convenience of carrying around an iPhone.

Image credit: www.choosemuse.com

“We don’t measure stress (with the Muse). What we’re actually measuring is a state of stable, focused attention,” Garten said. “When you hone your mind into a state of stable focused attention, what you’re able to do is resist the thoughts that you have and the distractions that you have. That helps you improve your cognitive function and attention. And, it also helps you decrease your stress, anxiety and all of the downstream physiological responses of that stress.”

Continue reading “Can A Brain-Machine Interface Help Train Your Mind?” »

Imagine these fighter jets being equipped with the DARPA death laser that is being worked on. Very deadly mix.

The size of a matchstick, the stentrode can provide the “brain-machine interface” or BMI necessary for thought-controlled devices. Neural implants currently in use require invasive surgery.

Stentrodes can be attached to the brain using catheter angiography. This procedure passes the device through blood vessels in the neck and into the brain without cutting open the skull.

Continue reading “DARPA Sees US Fighter Jets as First Thought-controlled Weapon” »

Good question.

Tiny balls of cancerous cells are being printed off by researchers at Heriot Watt University in Edinburgh who hope it can provide new ways of testing drugs and studying brain cancers.

Continue reading “Can 3D printing brain tumours help fight cancer?” »

DARPA’s new mind control fighter jets (BMIs are coming here soon) — BMI tech will mean smart devices will not be needed by most of the population.

University of Melbourne has developed an implant that could plug the brain directly into a vehicle.

A device the size of a matchstick, implanted next to the brain’s motor cortex, could one day help paralysed people move their limbs.

Interesting.

Futurists are accustomed to launching headfirst into some very complex subjects, but even the most high-minded and enthusiastic of prognosticators may take a pass when it comes to dealing with the future of sleep.

That’s no cop out.

Continue reading “We talked to futurists about what sleep will be like in 2030” »

Awesome.

Researchers have developed a new gene editing tool that is more efficient and easier to use. CRISPR-EZ addresses the issue of target RNA accuracy and embryo viability in IVF transgenic mice.

( andrew modzelewski/lin he | university of california berkeley )

Continue reading “More Efficient CRISPR Gene Editing May Potentially Help Cure Diseases” »