Lifeboat Foundation

Controlling the minds of others from a distance has long been a favourite science fiction theme – but recent advances in genetics and neuroscience suggest that we might soon have that power for real. Just over a decade ago, the bioengineer Karl Deisseroth and his colleagues at Stanford University published their paper on the optical control of the brain – now known as optogenetics – in which the firing pattern of neurons is controlled by light. To create the system, they retrofitted neurons in mouse brains with genes for a biomolecule called channelrhodopsin, found in algae. Channelrhodopsin uses energy from light to open pathways so that charged ions can flow into cells. The charged ions can alter the electrical activity of neurons, influencing the animal’s behaviour along the way.

Soon researchers were using implants to guide light to channelrhodopsin in specific neurons in the brains of those mice, eliciting behaviour on demand. At the University of California the team of Anatol Kreitzer worked with Deisseroth to disrupt movement, mimicking Parkinson’s disease and even restoring normal movement in a Parkinsonian mouse. Deisseroth and his colleague Luis de Lecea later demonstrated that it was possible to wake up mice by activating a group of neurons in the brain that control arousal and sleep.

But optogenetics has been challenging. Since light does not easily penetrate dense fatty brain tissue, researchers must implant a fibre-optic cable to bring light into the brain. This limitation led to the development of another, less intrusive technique known as DREADD (designer receptors exclusively activated by designer drugs). In this case, a receptor normally activated by the neurotransmitter acetylcholine is modified to respond to a designer drug not normally found in the body. When the designer drug is delivered, neurons can be manipulated and behaviour changed over a number of hours. The major drawback here: the slow course of drug administration compared with the rapid changes in brain activity that occur during most tasks.

Continue reading “Remote control of the brain is coming: how will we use it?” »

Eight completely paralysed people have regained function in their limbs following virtual reality training, in an accidental result that has astonished even the scientists involved.

Using a brain-machine interface, scientists showed that people with long-term severe paralysis could retrain the few remaining connections in their damaged spines, letting their brains talk to their extremities once more. This enabled them to feel sensation, move their limbs and improved their bladder and bowel control.

The results came about as a wholly unexpected side effect of training to help people use robotic exoskeletons, which let them walk upright.

Continue reading “Paralysed patients move limbs after virtual reality training” »

G. Owen Schaefer, National University of Singapore

Would you want to alter your future children’s genes to make them smarter, stronger or better-looking? As the state of the science brings prospects like these closer to reality, an international debate has been raging over the ethics of enhancing human capacities with biotechnologies such as so-called smart pills, brain implants and gene editing. This discussion has only intensified in the past year with the advent of the CRISPR-cas9 gene editing tool, which raises the specter of tinkering with our DNA to improve traits like intelligence, athleticism and even moral reasoning.

Researchers at the University of Washington in Seattle say that we need to act fast to implement a privacy and security framework to prevent our brain signals from being used against us before the technology really takes off…

Brain-computer interfaces offer new applications for our brain signals—and a new vector for security and privacy violations.

Neuroscientist Andrew B. Newberg provides the answer.

Computation of motion by T4 cells in the fly brain more complex than previously believed

Max-Planck-Gesellschaft.

Interview conducted by April Cashin-Garbutt, MA (Cantab)

Prior to your study, how much was known about the way brain circuits develop? How has your recent study advanced our understanding?

There’s a tremendous amount known about brain circuit development. Our work was inspired by experiments that were done over 50 years ago by scientists at Harvard University, Hubel and Wiesel. They received a Nobel Prize for their work and have inspired many additional experiments over the last 50 or 60 years.

Continue reading “Understanding brain circuit development: an interview with Dr Hollis Cline” »

Indeed, if we set ethical and safety objections aside, genetic enhancement has the potential to bring about significant national advantages. Even marginal increases in intelligence via gene editing could have significant effects on a nation’s economic growth. Certain genes could give some athletes an edge in intense international competitions. Other genes may have an effect on violent tendencies, suggesting genetic engineering could reduce crime rates.

We may soon be able to edit people’s DNA to cure diseases like cancer, but will this lead to designer babies? If so, bioethicist G Owen Schaefer argues that China will lead the way.

University of California, Berkeley engineers have designed and built millimeter-scale device wireless, batteryless “neural dust” sensors and implanted them in muscles and peripheral nerves of rats to make in vivo electrophysiological recordings.

Continue reading “Ultrasonic wireless ‘neural dust’ sensors monitor nerves, muscles in real time” »