Lifeboat Foundation

Does anyone remember this from July 2019? 🤔.

Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mice. HIV-1 subgenomic DNA fragments, spanning the long terminal repeats and the Gag gene, are excised in vivo, resulting in elimination of integrated proviral DNA; virus is not detected in blood, lymphoid tissue, bone marrow and brain by nested and digital-droplet PCR as well as RNAscope tests. No CRISPR-Cas9 mediated off-target effects are detected. Adoptive transfer of human immunocytes from dual treated, virus-free animals to uninfected humanized mice fails to produce infectious progeny virus. In contrast, HIV-1 is readily detected following sole LASER ART or CRISPR-Cas9 treatment. These data provide proof-of-concept that permanent viral elimination is possible.

Stephen Wolfram is a cult figure in programming and mathematics. He is the brains behind Wolfram Alpha, a website that tries to answer questions by using algorithms to sift through a massive database of information. He is also responsible for Mathematica, a computer system used by scientists the world over.

Last week, Wolfram launched a new venture: the Wolfram Physics Project, an ambitious attempt to develop a new physics of our Universe.

The new physics, he declares, is computational. The guiding idea is that everything can be boiled down to the application of simple rules to fundamental building blocks.

Researchers have confirmed that neuropeptide somatostatin can improve cognitive function in the brain. A research group of Professor Seung-Hee Lee from the Department of Biological Sciences at KAIST found that the application of neuropeptide somatostatin improves visual processing and cognitive behaviors by reducing excitatory inputs to parvalbumin-positive interneurons in the cortex.

This study, reported at Science Advances on April 22nd, sheds a new light on the therapeutics of neurodegenerative diseases. According to a recent study in Korea, one in ten seniors over 65 is experiencing dementia-related symptoms in their daily lives such as memory loss, cognitive decline, and motion function disorders. Professor Lee believes that somatostatin treatment can be directly applied to the recovery of cognitive functions in Alzheimer’s disease patients.

Professor Lee started this study noting the fact that the level of somatostatin expression was dramatically decreased in the cerebral cortex and cerebrospinal fluid of Alzheimer’s disease patients.

A brain-computer interface has helped a man with a severe spinal cord injury move and feel using a hand again, letting him carefully lift light objects such as a paper cup.

US researchers report that they have been able to restore sensation to the hand of a research participant with a severe spinal cord injury using a brain-computer interface (BCI) system.

Strokes, seizures, loss of smell and taste and other neurological deficits are showing up in patients critically ill with the coronavirus.

Although the virus is classified as a respiratory disorder and primarily damages the lungs, clinicians are seeing patients with a wide array of symptoms, from seizures to hallucinations, brain inflammation, disorientation, delirium and loss of smell and taste.

“I had a patient, a young guy, 48, who attended a party in New Rochelle two weeks before and came in with hallucinations and confusion,” said Dr. Pooia Fattahi, regional chair of neurology for Trinity Health Of New England. The patient had no fever and only a slight cough. Still, aware some COVID-19 patients show up at hospitals with seizures, strokes and confusion, Fattahi suspected, correctly, that the patient had COVID-19. Three of those who attended the same New Rochelle party ultimately died of the virus.

Researchers have found a way to decode neural signals and transform them back into movement and touch sensation for paralyzed patients.

:ooooo.

Most research about the genetics of schizophrenia has sought to understand the role that genes play in the development and heritability of schizophrenia. Many discoveries have been made, but there have been many missing pieces. Now, UNC School of Medicine scientists have conducted the largest-ever whole genome sequencing study of schizophrenia to provide a more complete picture of the role the human genome plays in this disease.

Published in Nature Communications, the study co-led by senior author Jin Szatkiewicz, PhD, associate professor in the UNC Department of Genetics, suggests that rare structural genetic variants could play a role in schizophrenia.

Continue reading “Whole genome sequencing reveals genetic structural secrets of schizophrenia” »

The virus is likely only to fuel the disaster preparedness industry in New Zealand and beyond. “Obviously the coronavirus is making people realize how vulnerable we all are, but what people are really concerned about is the aftermath,” said Vicino, the Vivos founder, who believes the wealthy fear an economic collapse or global depression could lead to uprisings against the top 1%. “They don’t want to have to defend their homes when the gangs of looters or marauders show up.”

Interest in New Zealand bunkers has surged.