Lifeboat Foundation

An international research team led by investigators at Virginia Commonwealth University has identified for the first time markers that may indicate early in life if a person has susceptibility to schizophrenia.

The ability to predict the risk of developing schizophrenia later in life may allow early detection and intervention, which the researchers hope can reduce the impact of the disease on individuals, families and communities. Their results have been published in Molecular Psychiatry.

Schizophrenia is a serious psychiatric disorder that is most often detected in young adulthood. It affects as much as 1% of the world population and can cause debilitating effects such as a sense of losing touch with reality. People with the disorder are up to three times more likely to die early and often face discrimination, social isolation and debilitating physical illness, according to the World Health Organization.

Note that this is very far away from a return to an anthropocentric worldview, to pre-Copernican times when the Earth was the center of Creation. (I call it biocentric to make the distinction clear.) Biocentrism is necessarily post-Copernican. I am saying that we are unique and important — but not for having been created by a god, or for being the result of a purposeful cosmic directive.

We are unique and important for being self-aware living entities capable of asking questions about their origin and future. We may not be the measure of all things as Protagoras of Abdera proclaimed long ago, but we are the things that can measure. We experience the world, we measure it, and we tell stories about what we see and what we feel. And what we are finding out is that we may very well be the only ones asking such questions — or, at the very least, the only ones we know of, which effectively amounts to the same thing. Even if “they” exist and tell stories, their stories will not be ours. There is only one human voice in the cosmos. And if we ruin our project of civilization, the Universe will once again become silent.

Continue reading “Why we are the only humans in the Universe and why it matters for our collective future” »

Researchers have found that for much of human evolutionary history our brains kept growing. In fact, if you count from our last shared ancestors with chimpanzees six million years ago, the human brain size almost quadrupled. This happened thanks in part to the improving diet and nutrition of early humans. Cro Magnons, the Homo sapiens that had the largest brains in history were alive from 20,000 to 30,000 years ago. But as the recent study from scientists at Dartmouth and Boston Universities points out, around 3,000 years ago, during the current Holocene geological epoch, our brains began to diminish.

A new study shows that areas of the brain that are responsible for movement are also connected to networks involved in thinking and planning, as well as the control of involuntary bodily actions.

Suvorexant (Belsomra), a dual orexin receptor antagonist approved for insomnia, reduced levels of tau phosphorylation and amyloid beta, a small clinical trialopens in a new tab or window showed.

The ratio of phosphorylated tau-threonine-181 (p-tau-181) to unphosphorylated tau-threonine-181 decreased 10% to 15% in cognitively normal adults treated with suvorexant 20 mg compared with placebo, reported Brendan Lucey, MD, MSCI, of Washington University School of Medicine in St. Louis, and co-authors.

Amyloid-beta levels fell 10% to 20% compared with placebo starting 5 hours after suvorexant administration, the researchers wrote in Annals of Neurologyopens in a new tab or window.

Continue reading “Alzheimer’s Proteins Reduced by Sleep Drug” »

Researchers at Baylor College of Medicine have unraveled the processes that give astrocytes, the most abundant glial cell in the brain, their special bushy shape, which is fundamental for brain function. They report in the journal Nature that neuronal activity is necessary and sufficient for astrocytes to develop their complex shape, and interrupting this developmental process results in disrupted brain function.

“Astrocytes play diverse roles that are vital for proper brain function,” said first author Yi-Ting Cheng, a graduate student in Dr. Benjamin Deneen’s lab at Baylor. “For instance, they support the activity of other essential brain cells, neurons; participate in the formation and function of synapses, or neuron-to-neuron connections; release neurotransmitters, chemicals that mediate neuronal communication; and make the blood-brain barrier.”

In the adult brain, the bushy shape of astrocytes is fundamentally linked to effective brain function. The ends of the branched-out astrocyte structure interact with neurons and regulate synaptic activity.

Summary: Researchers shed new light on the molecular and genetic basis of long-term memory formation in the brain. A new study reveals a single stimulation to the synapses of hippocampal neurons triggered numerous cycles where the memory-coding Arc gene produced mRNA molecules that were then translated into synapse-strengthening Arc proteins. From the findings, researchers determined a novel feedback loop that helps explain how short-lived mRNA and proteins create long-term memories in the brain.

Source: albert einstein college of medicine.

Helping your mother make pancakes when you were three…riding your bike without training wheels…your first romantic kiss: How do we retain vivid memories of long-ago events?

Summary: An international team of scientists has identified a gene in the brain responsible for anxiety symptoms and found that modifying the gene can reduce anxiety levels, offering a novel drug target for anxiety disorders. The discovery highlights a new amygdala miR483-5p/Pgap2 pathway that regulates the brain’s response to stress and provides a potential therapeutic approach for anxiety disorders.

Source: University of Bristol.

A gene in the brain driving anxiety symptoms has been identified by an international team of scientists. Critically, modification of the gene is shown to reduce anxiety levels, offering an exciting novel drug target for anxiety disorders.

An anti-cancer gel promises to wipe out glioblastoma permanently, a feat that’s never been accomplished by any drug or surgery. So what makes this gel so special?

Scientists at Johns Hopkins University (JHU) have developed a novel gel that both eliminates brain cancer (glioblastoma) and keeps it from recurring. When they tested this anti-cancer gel on mice with glioblastoma, surprisingly, all the mouse models were cured of the illness.

Continue reading “New study reveals a gel that promises to wipe out brain cancer for good” »