Lifeboat Foundation

Many intractable diseases are the result of a genetic mutation. Genome editing technology promises to correct the mutation and thus new treatments for patients. However, getting the technology to the cells that need the correction remains a major challenge. A new study led by CiRA Junior Associate Professor Akitsu Hotta and in collaboration with Takeda Pharmaceutical Company Limited as part of the T-CiRA Joint Research Program reports how lipid nanoparticles provide an effective means for the delivery to treat Duchenne muscular dystrophy (DMD) in mice.

Last year’s Nobel Prize for Chemistry to the discoverers of CRISPR-Cas9 cemented the impact of genome editing technology. While CRISPR-Cas9 can be applied to agriculture and livestock for more nutritious food and robust crops, most media attention is on its medical potential. DMD is just one of the many diseases that researchers foresee a treatment using CRISPR-Cas9.

“Oligonucleotide drugs are now available for DMD, but their effects are transient, so the patient has to undergo weekly treatments. On the other hand, CRISPR-Cas9 effects are long lasting,” said Hotta.

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In a paper published today in the scientific journal Science, DeepMind demonstrates how neural networks can be used to describe electron interactions in chemical systems more accurately than existing methods.

Density Functional Theory, established in the 1960s, describes the mapping between electron density and interaction energy. For more than 50 years, the exact nature of mapping between electron density and interaction energy—the so-called density functional—has remained unknown. In a significant advancement for the field, DeepMind has shown that neural networks can be used to build a more accurate map of the density and interaction between electrons than was previously attainable.

Continue reading “Simulating matter on the nanoscale with AI” »

Graphene consists of a planar structure, with carbon atoms connected in a hexagonal shape that resembles a beehive. When graphene is reduced to several nanometers (nm) in size, it becomes a graphene quantum dot that exhibits fluorescent and semiconductor properties. Graphene quantum dots can be used in various applications as a novel material, including display screens, solar cells, secondary batteries, bioimaging, lighting, photocatalysis, and sensors. Interest in graphene quantum dots is growing, because recent research has demonstrated that controlling the proportion of heteroatoms (such as nitrogen, sulfur, and phosphorous) within the carbon structures of certain materials enhances their optical, electrical, and catalytic properties.

The Korea Institute of Science and Technology (KIST, President Seok-Jin Yoon) reported that the research team led by Dr. Byung-Joon Moon and Dr. Sukang Bae of the Functional Composite Materials Research Center have developed a technique to precisely control the bonding structure of single heteroatoms in the graphene quantum dot, which is a zero-dimensional carbon nanomaterial, through simple chemical reaction control; and that they identified the relevant reaction mechanisms.

With the aim of controlling heteroatom incorporation within the graphene quantum dot, researchers have previously investigated using additives that introduce the heteroatom into the dot after the dot itself has already been synthesized. The dot then had to be purified further, so this method added several steps to the overall fabrication process. Another method that was studied involved the simultaneous use of multiple organic precursors (which are the main ingredients for dot synthesis), along with the additives that contain the heteroatom. However, these methods had significant disadvantages, including reduced crystallinity in the final product and lower overall reaction yield, since several additional purification steps had to be implemented. Furthermore, in order to obtain quantum dots with the chemical compositions desired by manufacturers, various reaction conditions, such as the proportion of additives, would have to be optimized.

The involvement between electron transfer (ET) and catalytic reaction at electrocatalyst surface makes electrochemical process challenging to understand and control. How to experimentally determine ET process occurring at nanoscale is important to understand the overall electrochemical reaction process at active sites.

Recently, a research group led by Prof. LI Can and Prof. FAN Fengtao from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) captured the electron transfer imaging in electrocatalysis process.

This study was recently published in the journal Nano Letters.

A common strategy to make vaccines more powerful is to deliver them along with an adjuvant — a compound that stimulates the immune system to produce a stronger response.

Researchers from MIT, the La Jolla Institute for Immunology, and other institutions have now designed a new nanoparticle adjuvant that may be more potent than others now in use. Studies in mice showed that it significantly improved antibody production following vaccination against HIV, diphtheria, and influenza.

“We started looking at this particular formulation and found that it was incredibly potent, better than almost anything else we had tried,” says Darrell Irvine, the Underwood-Prescott Professor with appointments in MIT’s departments of Biological Engineering and Materials Science and Engineering; an associate director of MIT’s Koch Institute for Integrative Cancer Research; and a member of the Ragon Institute of MGH, MIT, and Harvard.

A 2D nanomaterial consisting of organic molecules linked to metal atoms in a specific atomic-scale geometry shows non-trivial electronic and magnetic properties due to strong interactions between its electrons.

A new study, published today, shows the emergence of magnetism in a 2D organic material due to strong electron-electron interactions; these interactions are the direct consequence of the material’s unique, star-like atomic-scale structure.

This is the first observation of local magnetic moments emerging from interactions between electrons in an atomically thin 2D organic material.

The extra juice comes from a secret ingredient…corn starch.

Could a simple materials change make electric car batteries able to four times more energy? Scientists in South Korea think so. In a new paper in the American Chemical Society’s Nano Letters, a research team details using silicon and repurposed corn starch to make better anodes for lithium ion batteries.

This team is based primarily in the Korea Institute of Science and Technology (KIST), where they’ve experimented with microemulsifying silicon, carbon, and corn starch into a new microstructured composite material for use as a battery anode. This is done by mixing silicon nanoparticles and corn starch with propylene gas and heating it all to combine.

Continue reading “Corny Lithium-Ion Batteries Could Hold Quadruple the Charge” »

“It is like using your thumb to control the water spray from a hose,” said Ming Liu, associate professor in UC Riverside’s Marlan. “You know how to get the desired spraying pattern by changing the thumb position, and likewise, in the experiment, we read the light pattern to retrieve the details of the object blocking the five nm-sized light nozzles.”

The light is then focused into a spectrometer, where it forms a tiny ring shape. The researchers can formulate the absorption and scattering images with colors by scanning the probe over an area and recording two spectra for each pixel.

The team expects the new nano-imaging technology can be an important tool to help the semiconductor industry make uniform nanomaterials with consistent properties for use in electronic devices. The new full-color nano-imaging technique could also be used to improve understanding of catalysis, quantum optics, and nanoelectronics.

It’s one thing to produce nano-scale materials, but it’s an entirely different thing imaging them.

Nanomaterials have many applications, especially in electronics, but they have one issue: They are so small that they don’t reflect enough light to show fine details, such as colors, even with the aid of the most powerful microscopes.

Now, researchers from UC Riverside may have come up with a solution. They have conceived of an imaging technology that compresses lamp light into a nanometer-sized spot, holding that light at the end of a silver nanowire. This allows it to reveal previously invisible details such as colors.

Continue reading “‘Squeezed’ Light Can Give Nano-Imaging a Much Needed Boost” »