Lifeboat Foundation

Lying within our muscles are stem cells, invisible engines that drive the tissue’s growth and repair. Understanding the signal(s) that direct muscle stem cells to spring into action could uncover new ways to promote muscle growth. However, these mechanisms are poorly understood.

Now, scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.

“Muscle stem cells can ‘burn out’ trying to regenerate tissue during the natural aging process or due to chronic muscle disease,” says Alessandra Sacco, Ph.D., senior author of the paper and associate professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys. “We believe we have found promising drug targets that direct muscle stem cells to ‘make the right decision’ and stimulate muscle repair, potentially helping muscle tissue regeneration and maintaining tissue function in chronic conditions such as muscular dystrophy and aging.”

Continue reading “Boosting muscle stem cells to treat muscular dystrophy and aging muscles” »

On the degenerative disk disease and senescent cells from FightAging: “… It is just a pity that so few older people know this at the present time — the hundreds of millions worldwide who are suffering when perhaps they need not be…”

At this point, I suspect it will surprise no-one who follows the field to learn that the accumulation of senescent cells is a significant cause of degenerative disc disease. The evidence from a mouse study that is provided in the open access paper here doesn’t quite rise to establishing that claim, but it is compelling nonetheless. Given the role of cellular senescence in arthritis, a disease of localized chronic inflammation, it is logical to also expect a role in the degeneration of intervertebral discs, as this is also a condition of aging in which inflammation seems important.

Senescent cells, even while present in only comparatively small numbers, generate a potent mix of molecules that spurs chronic inflammation and is destructive of surrounding tissue structure. Fortunately early senolytic compounds, those shown to destroy a sizable fraction of senescent cells cells in animal studies, are cheap and readily available to anyone willing to try this self-experiment. It is just a pity that so few older people know this at the present time — the hundreds of millions worldwide who are suffering when perhaps they need not be.

Researchers at Northwestern University have used a non-invasive form of magnetic brain stimulation to improve the memory of older adults. After just five short sessions the older adults scored as well as a younger cohort on a variety of memory tasks.

A new story on my latest article from #transhumanism critic Wesley J. Smith:

Oh my. Two of contemporary society’s most prominent anti-human utopian movements — radical environmentalism and materialistic transhumanism — appear on the verge of a bitter showdown.

When you think about it, that makes sense. Both movements see themselves as the future’s only hope. But their core purposes are incompatible. Radical environmentalists — “nature rights” activists, deep ecologists, Gaia theorists, and their fellow travelers that elevate nature above humanity — hijacked and refashioned traditional environmentalism into a mystical neo-earth religion that disdains homo Sapiens as a parasitical species afflicting the earth. These radicals hope to thwart our thriving off the land in order to “save the planet.” Indeed, I sometimes believe that if they could, they would forcibly revert our species to hunter/gatherers — without the hunting part.

Continue reading “Radical Environmentalism and Transhumanism: Symptoms of the Same Disease” »

Yale is making waves. They have had great Research papers over the past 3 years. Some of which has proven my constant words now for two decades that we have a pandemic plague that attacks our individual Eukaryotic cells the day long causing What AEWR Has named the Senesonic plague the disease we have called aging. Respect r.p.berry & AEWR https://adamandevewordresearch.blogspot.com/

The researchers did not hail from House Greyjoy — “What is dead may never die” — but came largely from the Yale School of Medicine. They connected 32 pig brains to a system called Brain Ex. Brain Ex is an artificial perfusion system — that is, a system that takes over the functions normally regulated by the organ. Think a dialysis machine for the mind. The pigs had been killed four hours earlier at a U.S. Department of Agriculture slaughterhouse; their brains completely removed from the skulls.

Brain Ex pumped an experiment solution into the brain that essentially mimic blood flow. It brought oxygen and nutrients to the tissues, giving brain cells the resources to begin many normal functions. The cells began consuming and metabolizing sugars. The brains immune system kicked in. Neuron samples could carry an electrical signal. Some brain cells even responded to drugs.

Continue reading “Yale scientists restore brain function of 32 dead pigs” »

https://www.youtube.com/watch?v=tY2APj5UEsw&feature=share

There is a link to the full vid. “Life extension escape velocity in 10 years.” Here is currently my favorite go to link in support of this potential: https://www.nextbigfuture.com/2019/01/delivery-of-45-age-rev…eview.html

Science CEO Liz Parrish are in a fight to eradicate diseases of aging. Preventive & regenerative gene therapies are key to fixing cellular death.

“Julie has been associated with SENS since its earliest days: she participated in the first workshop that I organised to discuss it, in 2000, and she was a co-author on the first SENS paper in 2002. We’re delighted to be funding her laboratory at the Buck Institute to explore new ways of eliminating neurofibrillary tangles from neurons of Alzheimer’s sufferers, and at UA2019 we will hear about their initial progress.” says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-julie-k-andersen-to-sp…Qq6fZbArkM #

#undoingaging #sens #foreverhealthy

Continue reading “Program: Happy to announce Prof. Julie K. Andersen at the Buck Institute for Research on Aging in Novato as a speaker for the 2019 Undoing Aging Conference” »

Videos will be released step by step over the next few weeks as we receive clearance from the individual speakers.

This week we kick it off with Jerry Shay, who is the Vice Chairman of the Department of Cell Biology at The University of Texas Southwestern Medical Center in Dallas, presenting ‘Telomeres and Telomerase in Aging and Cancer‘.

undoing-aging.org/…/jerry-shay-presenting-at-undoing-aging-…

Continue reading “We are starting to share a selection of the exciting talks at our 2019 Undoing Aging conference” »