Lifeboat Foundation

In the past few decades, researchers discovered that the rate at which we age is strongly influenced by biochemical processes that, at least in animal models, can be controlled in the laboratory. Telomere shortening is one of these processes; another is the ability of cells to detect nutrients mediated by the mTOR protein. Researchers have been able to prolong life in many species by modifying either one of them. But what if they manipulate both?

A team from the Spanish National Cancer Research Centre (CNIO) has studied it for the first time, with unexpected results. Blocking nutrient sensing by treatment with rapamycin, an mTOR inhibitor, delays the aging of healthy mice, but curiously, it worsens diseases and premature aging that occur in mice with short telomeres. This finding has important implications for the treatment of diseases associated with short telomeres, but also for age-related diseases that are also associated with short telomeres. The study, done by the Telomeres and Telomerase Group headed by Maria Blasco at the CNIO, is published in Nature Communications with Iole Ferrara-Romeo as the first author.

Telomeres, regions of repetitive nucleotide sequences at the end of chromosomes, preserve the genetic information of the cells. They shorten with age until they can no longer fulfill their function: The cells stop dividing and the tissues age since they are no longer able to regenerate.

Researchers say brain pathways begin to erode in late 40s, but can be repaired through dietary changes.

Stem cells are possibly Nature’s best-stored secret. These cells, which might be discovered in multicellular organisms, including humans, no longer handiest have the capability to divide (mitosis) but additionally to form various structures such as cartilage, bone and lots of more. The procedure is called as differentiation.

Stem cell knee surgery can be used to successfully treat a wide range of acute and chronic knee situations and injuries. Thanks to advancements in regenerative medicine, we are capable of use stem cell therapy as a possible alternative to many invasive techniques consisting of, total knee joint replacement surgical treatment and arthroscopic knee surgical procedure, to treat knee pain. Additionally, stem cell therapy may additionally be ideally suited for people who do not qualify for surgical processes.

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Accelerating rejuvenation therapies to repair the damage of aging.

Continue reading “Undoing Aging 2020” »

Hype or hyper-exciting? Kate Batz of Longevity. Capital shares her views on the Longevity landscape and its investment potential: pragmatic optimism, but full of opportunity.

Should we be forced to die? Live? We’re going to dig into some deep questions about health and longevity in our discussion this week with the CEO of BioViva Sciences, Elizabeth Parrish. BioViva is dedicated to improving healthy human longevity through bioinformatics used in health predictions and recommendations, precision medicine, and the discovery of novel biomarkers by applying state of the art computational methods on vast collections of biological data.

DARPA has established a new partnership with U.S. industry to jointly develop and deploy advanced robotic capabilities in space. The agency has signed an Other Transactions for Prototypes agreement with Space Logistics, LLC, a wholly-owned subsidiary of Northrop Grumman Corporation, as its commercial partner for the Robotic Servicing of Geosynchronous Satellites (RSGS) program.

The RSGS program’s objective is to create a dexterous robotic operational capability in geosynchronous orbit that can extend satellite life spans, enhance resilience, and improve reliability for current U.S. space infrastructure. The first step is the RSGS program’s development of a dexterous robotic servicer, which a commercial enterprise will then operate.

“DARPA remains committed to a commercial partnership for the execution of the RSGS mission,” said Dr. Michael Leahy, director of DARPA’s Tactical Technology Office. “Building upon the successes of the DARPA Orbital Express mission and the recent successful docking of Space Logistics’ Mission Extension Vehicle-1, the agency seeks to bring dexterous on-orbit servicing to spacecraft in geosynchronous orbit (GEO), and to establish that inspection, repair, life extension, and improvement of our valuable GEO assets can be made possible and even routine.”

Ogba Educational Clinic

EXCLUSIVE: In a plot which seems straight out of the Netflix original series Altered Carbon, experts have told Daily Star Online the wealthy could soon achieve immortality.

One of the hallmarks of cancer is cell immortality. A Northwestern University organic chemist and his team now have developed a promising molecular tool that targets and inhibits one of cell immortality’s underlying gears: the enzyme telomerase.

This enzyme is found overexpressed in approximately 90% of human cancer cells and has become an important subject of study for cancer researchers. Normal cells have the gene for telomerase, but it typically is not expressed.

“Telomerase is the primary enzyme that allows cancer cells to live forever,” said Karl A. Scheidt, who led the research. “We want to short-circuit this immortality. Now we have designed a first-of-its-kind small molecule that irreversibly binds to telomerase, shutting down its activity. This mechanism offers a new pathway for treating cancer and understanding cellular aging.”