Lifeboat Foundation

Brain Muraresku, author of “The Immortality Key — The Secret History Of The Religion With No Name”, discussing his fascinating journey to discover psychedelic potions from antiquity, reconstruct their history in the development of religion and civilization, and their development into a modern neuro-pharmacopoeia.

On today’s show we are going to be weaving together a really interesting range of themes including psychedelics, pharmacognosy and medicinal botany, history, religion & spirituality, end of life care, dreaming, mental health and a whole lot more.

Continue reading “The Immortality Key — Brain Muraresku — The Secret History Of The Religion With No Name” »

Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss, fight certain types of prostate cancer, and even enhance cognition in healthy animals.

In the new study, published Dec. 1, 2020, in the open-access journal eLife, researchers showed rapid restoration of youthful cognitive abilities in aged mice, accompanied by a rejuvenation of brain and immune cells that could help explain improvements in brain function.

“ISRIB’s extremely rapid effects show for the first time that a significant component of age-related cognitive losses may be caused by a kind of reversible physiological “blockage” rather than more permanent degradation,” said Susanna Rosi, PhD, Lewis and Ruth Cozen Chair II and professor in the departments of Neurological Surgery and of Physical Therapy and Rehabilitation Science.

**Peroxisomes are compartments where cells turn fatty molecules into energy and useful materials, like the myelin sheaths that protect nerve cells. In humans, peroxisome dysfunction has been linked to severe metabolic disorders, and peroxisomes may have wider significance for neurodegeneration, obesity, cancer and age-related disorders.**

Peroxisomes are also highly conserved, from plants to yeast to humans, and Bartel said there are hints that these structures may be general features of peroxisomes.

“Peroxisomes are a basic organelle that has been with eukaryotes for a very long time, and there have been observations across eukaryotes, often in particular mutants, where the peroxisomes are either bigger or less packed with proteins, and thus easier to visualize,” she said. But people didn’t necessarily pay attention to those observations because the enlarged peroxisomes resulted from known mutations.

Continue reading “Hidden structure found in essential metabolic machinery” »

Dr leonard hayflick — father of cell senescence!

Dr. Leonard Hayflick, is Professor of Anatomy, University of California, San Francisco School of Medicine, where he has been part of the faculty since 1988.

Continue reading “Dr. Leonard Hayflick — Cellular Senescence, Mycoplasmology, and Viral Vaccine Development” »

Scientists stress that the symptoms of space travel aren’t exactly the same as aging, and many changes reverse themselves once people return to Earth, but the comparisons are still useful. Spaceflight is an immersive experience that spares no traveler, while aging happens to every Earthling whether we like it or not. As such, life in space is a good model for understanding aging as a chronic process, Bailey says. The barren otherworld of outer space could even reveal new ways to protect ourselves against the process of growing old.

Space travel induces bodily changes that are remarkably similar to growing old, providing a unique way to boost medical research.

Longevity biotech firm BioAge Labs is readying itself for clinical trials after raising a whopping $90 million Series C funding round. The company revealed it will be moving its lead platform-derived therapies, BGE-117 and BGE-175, into Phase 2 clinical trials in the first half of 2021.

Longevity. Technology: As the developer of an AI platform that maps the molecular pathways impacting human Longevity, we’ve followed developments at BioAge with great interest. With two compounds ready to enter the clinic next year, and more on the way, this company is fast-becoming one of Longevity’s most exciting prospects.

The new funds will be used to develop BioAge’s portfolio of therapies for increasing healthspan and lifespan, as well as to augment its AI platform, and further expand its capabilities to test drug candidates in predictive models of human diseases of aging.

Researchers claim to have reversed ageing in mice. It has long been believed that if we understand the causes of ageing, it may be possible to reverse it. New work on mice shows that it is possible to cure vision loss caused by old age or injury. Researchers think that this effect may depend on rewinding the ‘biological clock’ which marks the age of cells, suggesting that the cells in the eye have been made functionally younger.

Read the paper here: https://www.nature.com/articles/s41586-020-2975-4

Continue reading “Rewinding the biological clock: How to reverse ageing” »

Harvard Medical School scientists have successfully restored vision in mice by turning back the clock on aged eye cells in the retina to recapture youthful gene function.

The team’s work, described Dec. 2 in Nature, represents the first demonstration that it may be possible to safely reprogram complex tissues, such as the nerve cells of the eye, to an earlier age.

In addition to resetting the cells’ aging clock, the researchers successfully reversed vision loss in animals with a condition mimicking human glaucoma, a leading cause of blindness around the world.

Simulations that model molecular interactions have identified an enzyme that could be targeted to reverse a natural aging process called cellular senescence. The findings were validated with laboratory experiments on skin cells and skin equivalent tissues, and published in the Proceedings of the National Academy of Sciences (PNAS).

“Our research opens the door for a new generation that perceives aging as a reversible biological phenomenon,” says Professor Kwang-Hyun Cho of the Department of Bio and Brain engineering at the Korea Advanced Institute of Science and Technology (KAIST), who led the research with colleagues from KAIST and Amorepacific Corporation in Korea.

Cells respond to a variety of factors, such as oxidative stress, DNA damage, and shortening of the telomeres capping the ends of chromosomes, by entering a stable and persistent exit from the cell cycle. This process, called cellular senescence, is important, as it prevents damaged cells from proliferating and turning into cancer cells. But it is also a natural process that contributes to aging and age-related diseases. Recent research has shown that cellular senescence can be reversed. But the laboratory approaches used thus far also impair tissue regeneration or have the potential to trigger malignant transformations.