Lifeboat Foundation

In mammals, the acquisition of the germline from the soma provides the germline with an essential challenge, the necessity to erase and reset genomic methylation¹. In the male germline, RNA-directed DNA methylation silences young active transposable elements (TEs)^2–4. The PIWI protein MIWI2 (PIWIL4) and its associated PIWI-interacting RNAs (piRNAs) instruct TE DNA methylation^3,5. piRNAs are proposed to tether MIWI2 to nascent TE transcripts; however, the mechanism by which MIWI2 directs de novo TE methylation is poorly understood but central to the immortality of the germline. Here we define the interactome of MIWI2 in foetal gonocytes that are undergoing de novo genome methylation and identify a novel MIWI2-associated factor, SPOCD1, that is essential for young TE methylation and silencing. The loss of Spocd1 in mice results in male-specific infertility but impacts neither piRNA biogenesis nor localization of MIWI2 to the nucleus. SPOCD1 is a nuclear protein and its expression is restricted to the period of de novo genome methylation. We found SPOCD1 co-purified in vivo with DNMT3L and DNMT3A, components of the de novo methylation machinery as well as constituents of the NURD and BAF chromatin remodelling complexes. We propose a model whereby tethering of MIWI2 to a nascent TE transcript recruits repressive chromatin remodelling activities and the de novo methylation apparatus through SPOCD1. In summary, we have identified a novel and essential executor of mammalian piRNA-directed DNA methylation.

Even healthy brains become less efficient as they age, but they do so at different rates for different tasks in different people. Understanding what contributes to this decline, and the ways in which that decline varies, can provide significant insight into the function of the brain.

In a new study, researchers at The University of Texas at Dallas documented how some parts of the brain perform differently over time in response to various kinds of visual input.

A team from the Center for Vital Longevity (CVL) analyzed a phenomenon called neural dedifferentiation, in which regions of the brain that normally are specialized to perform distinct tasks become less selective in their responses to stimulus types.

I hope they get funding.

SAN DIEGO — The average American lives to be around 75 or 80 years old; but if you had an opportunity to slow down the aging process and live an extra couple of decades would you take it? It’s a loaded question, strife with philosophical, religious, and societal considerations. Humans have pondered the possibilities of extended, or even immortal, life for as long as we’ve inhabited this planet. But at the end of the day it’s all just a daydream, right?

Not necessarily, according to new research out of the University of California, San Diego. The study, led by UCSD molecular biologists and bioengineers, produced a groundbreaking discovery regarding the intricacies of cellular aging. In light of their findings, researchers say the notion of “dramatically” extending human life isn’t so farfetched after all.

Continue reading “Cellular aging ‘master circuit’ discovered: Extended human lifespan to follow?” »

While the issue of aging and DNA methylation is an area that is well-studied, modifications of DNA to reduce or reverse aging remains an area in need of exploration. Studies in mice utilizing interventions such as caloric restriction and the drug rapamycin have reversed and/or slowed age-related DNA methylation by up to 40%. Understanding the cross-species aging based on similar DNA behaviors may open more doors to investigating therapeutics to minimize lifetime risks of age-related illnesses such as Alzheimer’s disease and cancers.

A recent study published in Cell Systems sought to debunk one of the most common myths about dogs: much to our surprise, one “dog year” does not equal seven “human years.” As described in a recent Forbes piece by Sara Tabin, the relationship between dog years and human years is not linear, but is based on a logarithmic formula. The research group, based at the University of California, San Diego (UCSD), created the formula as follows:

Age in human years = 16 ln(age in dog years) +31. (ln means “natural logarithm).

Continue reading “The Answer To Anti-Aging Therapies May Lie In Your Aging Dog” »

Japan boasts one of the longest life expectancies on earth, and it also a world leader in “healthy life expectancy”—the number of years of good health people can expect on average. Since diet is believed to play a key role in a population’s health and longevity, researchers around the world have been studying the benefits of the Japanese diet for some time now.

But what exactly is the Japanese diet? The people of Japan do not dine primarily on sushi, tempura, or other well-known Japanese specialties. Moreover, their eating habits have changed over the years. For our research, we used national surveys to compile weekly menus representative of the Japanese diet at various points in time over the past half century. In the following, we will take a look at the comparative health effects of these menus.

The health benefits of Japanese cooking are widely touted, but what exactly is a healthy Japanese diet? Food scientists in Japan have homed in on the nutritional keys to health and longevity, and their conclusions may bode ill for the younger generation.

Continue reading “The ‘1975 Diet’ and the Secret of Japanese Longevity” »

Nanoscale thermal physics guarantees our decline, no matter how many diseases we cure.

Posthuman Buddhism isn’t restricted to human-era schools or traditions, These (previously unpublished) tsakli are from all Vajrapani schools. Unlike Eastern cultures, in the West we do not require a “Guru” and tsakli can be used for “self-initiation”. Unlike religions that make truth claims for supernatural beings or impossible events, Buddhism sees any deities (peaceful or wrathful) as self-originating. The future surely lies with psychomorphological approaches that are amenable to — and not contradictory — to science.

This new book, 4 in the series, contains fourteen rare and unusual C17th or C18th “Grande Tsaklis”, another four late C18th examples reportedly originating from Tsurphu monastry, plus two extremely large tsakli (giants in tsakli terms) one depicting a wind horse whilst the other shows a figure in historically early clothes with butterlamp, male and female deer and an elephant, C16th to C18th. All fronts and reverse (texts) of tsakli are shown.

These 13 plus (1 from different series of the grandes tsakli) detail rituals to be performed at certain times of the year that promote longevity and ward off evil influences. Astrological and various motifs and ritual implements are shown in the compartments, and crucial text is in the triangles. Some have damage (below missing top part of red border). All 20 are rare.

Continue reading “20 Grand Tsakli of Tibet and relaunch of tsakli” »

For the first time, scientists have introduced minuscule tracking devices directly into the interior of mammalian cells, giving an unprecedented peek into the processes that govern the beginning of development. This work on one-cell embryos is set to shift our understanding of the mechanisms that underpin cellular behaviour in general, and may ultimately provide insights into what goes wrong in ageing and disease.

The research, led by Professor Tony Perry from the Department of Biology and Biochemistry at the University of Bath, involved injecting a silicon-based nanodevice together with sperm into the egg cell of a mouse. The result was a healthy, fertilised egg containing a tracking device.

The tiny devices are a little like spiders, complete with eight highly flexible ‘legs’. The legs measure the ‘pulling and pushing’ forces exerted in the cell interior to a very high level of precision, thereby revealing the cellular forces at play and showing how intracellular matter rearranged itself over time.

Want to learn how we age and whether we can slow or even reverse aging? David Sinclair, PhD, professor of genetics at Harvard Medical School, says in his book “Lifespan” that aging is a disease, and that disease is treatable. Tune in to Homeroom with Sal on Tuesday at noon PT to get your questions answered by a leading expert on aging and age-associated diseases.

For more information visit: keeplearning.khanacademy.org

Continue reading “Homeroom with Sal & David Sinclair, PhD — Tuesday, July 14” »