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Oct 2, 2021

Kimberly A Reed — Fmr EXIM Chairman / President — Stimulating STEM & Securing U.S. High-Tech Economy

Posted by in categories: biotech/medical, business, economics, finance, food, government, health, internet, robotics/AI

Stimulating STEM Innovation & Securing U.S. High-Tech Economy — Kimberly A. Reed, Fmr President and Chairman Export-Import Bank of the United States.


Kimberly A. Reed just finished up a 2-year term as President and Chairman of the Board of Directors of the Export-Import Bank of the United States (EXIM — https://www.exim.gov). She was the first woman to lead EXIM in the agency’s 87-year history, was the first recipient of EXIM’s highest honor, the Franklin D. Roosevelt Award, and was confirmed by the U.S. Senate in 2019 on a strong bi-partisan basis.

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Oct 1, 2021

Brain imaging reveals artificial sweeteners can increase food cravings

Posted by in categories: biotech/medical, food

Artificial sweeteners are widely promoted as safe, zero-calorie alternatives to sugar, ideal for those trying to lose weight. But a new study is indicating artificial sweeteners may increase appetite and food cravings, particularly in females and the obese.

“There is controversy surrounding the use of artificial sweeteners because a lot of people are using them for weight loss,” says corresponding author on the new study, Kathleen Page. “While some studies suggest they may be helpful, others show they may be contributing to weight gain, type 2 diabetes and other metabolic disorders. Our study looked at different population groups to tease out some of the reasons behind those conflicting results.”

Page hypothesizes the discordancy in the science is somewhat due to the fact that many studies investigating the effects of artificial sweeteners on metabolic activity or the brain are conducted in mostly male subjects, often with normal weight. This new research set out to investigate the influence of artificial sweeteners on these processes across a broad cohort of men and women.

Sep 30, 2021

Manufacturers allowed baby food contaminated with heavy metals to remain on shelves, lawmakers say

Posted by in category: food

The testing found 95% of sampled baby foods contained lead, 73% contained arsenic, 75% contained cadmium and 32% contained mercury. One fourth of the baby foods contained all four heavy metals. The results mimicked a previous study by the US Food and Drug Administration that found one or more of the same metals in 33 of 39 types of baby food tested.


Just months after a congressional investigation found manufacturers have failed to test for toxic metals in the baby foods they sell, lawmakers report that some companies are not testing and removing these products from the marketplace.

Sep 29, 2021

The iPhone of Robotics

Posted by in categories: biotech/medical, business, economics, food, health, information science, mobile phones, robotics/AI

The killer product of robotics is hidden in plain sight and may be just a few years away. Summary The robotic space is still waiting for a truly widespread general purpose product which deeply changes our everyday life. I argue that such a product could be a low cost collaborative manipulator powered by an ecosystem of AI-based applications. It will create value in novel ways and automate tasks at an unthinkable price point, impacting both our homes and businesses. As in the case of smartphones, the real value is in the apps sitting in the app store, which will be built by a new generation of startups and creators. I analyse where we stand and I predict that we are just a few years away from seeing such a product go live. Manipulators State of the Art in Brief When thinking about manipulators or robotic arms, the first thing that pops to your mind is probably an industrial robot, as the one in the picture: These robots are precise, fast, durable and capable of lifting heavy weights. They are also very dangerous, therefore they need to be fenced and kept separate from human workers. A more recent development is the introduction of collaborative robots or cobots. These robots are generally slower than industrial robots, but they are safe to work in direct contact with humans thanks to sensors and algorithms to detect collisions and stop the robot motion just in time, enabling many new use-cases. The market leader is Universal Robotics, a Danish company which recently sold its robot number 50.000. In 2021 the cheapest UR cobot can be purchased for about 20.000 dollars, but there are more affordable competitors which are sold for less than 10.000 dollars. The future looks bright for collaborative robots and for us consumers, since the price is expected to keep going down quickly following Wright’s Law, that is the price should be reduced by a fixed percentage every times the number of units sold is doubled. Keep in mind that UR sold its robot number 25.000 in 2,018 so it doubled the number of all-time robots sold in just two years! Still, if you go through the tech specs of these arms you will start noticing something, see here and here. Current robotic arms are overqualified for many of the mundane tasks we would like them to do, for instance in our kitchens and homes. Seriously, look at the UR5, when was the last time you loaded a dishwasher with 0.1 millimeter precision? Or which kitchen appliance did you use for 35.000 hours at full capacity? Or what clothes weigh 5+ kilograms? On the other side of the tech specs there is a market for toy robots and desktop robots, which are inexpensive, but unfortunately suffer from limited arm reach, payload and overall reliability. Can a hybrid be built? I think so, and it may very well be the killer product of robotics. What does the iPhone of Robotics look like? The killer product of robotics may be a collaborative robot which is intuitive to use and low cost, by making trade offs with speed and accuracy. Drawing from my research, this is how I believe it will look like: Must Have: Low cost: Less than 1,000 USD for the robot hardware. Compatible with a wide set of end effectors, to cover multiple use cases. Lightweight and Compliant: Able to interact safely in environments with untrained staff and children, easy to physically carry around. Self-contained and Portable: it includes a computing platform, with a form factor similar to a Raspberry pi or Jetson Nano and a standard networking stack (Wifi, Bluetooth). It should be easy to deploy third party apps on it. Nice to Have: 6 Degrees of Freedom (while 7 DOF gives more flexibility, 6 DOF can already reach any position in the workspace, but are easier to control and more affordable) Reach 700mm Payload 2Kg Repeatability 1mm Max Speed 0.5 m/s Operating Lifetime 10,000 hours at full capacity. Open Source and ROS compatible Payload and Reach are very use cases dependent. If I had to pick a sweet spot for a general purpose robot, I would say 3kg and 750mm. One of the crucial points above is the possibility to install third party apps. Today, robotic companies are forced to curate the whole software-hardware stack to deliver a product, so the company building the robot behaviours (say the algorithms to control the stirring movements of an omelette-making robot) are also the companies selling the robotic hardware to the end customer. Sometimes they are also the companies building the hardware, even if it’s more common to see companies buying hardware off the shelf, say a UR cobot, and customising it. On top of this, today the same companies also build the user interface, say a mobile app, to actually control the robot. When a popular general purpose cobot will be available on the market, there will start to be a clear division between the company selling the general purpose hardware (and the onboard app-store) and the companies building apps for it, that is the skills of the cobot. Translated into the smartphone dictionary, the robot and app store store manufacturer is Apple, while the app developers are Facebook, Netflix, etc. To further stress the analogy, you may think of your smartphone as a very limited robot, with capabilities such as making sounds and coloring the screen, but with no movement capabilities (apart from vibrations!). A cobot will have multiple apps installed, exactly as our smartphones, and will be able to perform different tasks as programmed by domain experts in each use case. These domain experts will be 100% software-based robotic companies. It is in this period that we will see an exponential growth in cobot capabilities, as companies can iterate quickly in software. To sustain this demand of new use cases, companies will mainly take approaches based on computer vision, supervised learning and reinforcement learning. In the very long term, I see a further division between robotic companies building the low-level APIs to control the robot and companies specialising in building the user interface to interact with the robot, which will include mobile apps, vocal and gesture commands. In the figure: Evolution of the robotic ecosystem over time (from 2026+ on, with robot manufacturers I’m only referring to the manufacturers of cobots allowing third party apps). The years indicate approximately the predicted first time we will see these models hitting the market. What will we use these collaborative robots for? Pretty much everything. Let’s do a quick calculation to see why I say this. Let’s assume that the apps will have a subscription fee comparable to today’s smartphone apps, say the approximately 20 USD of Nextlix monthly subscription. By the way, given the success of the freemium model for mobile apps, I would not be surprised to see free to use robot skills. Also let’s say that each cobot will last about 3 years. This is much less than what a cobot could last, but it’s in line with the replacement cycle of our high end gadgets such as smartphones (we should strive to do better, the environment would be thankful). As a final assumption, let’s add another 30 USD monthly for a subscription package that includes robot maintenance and support plus the cost of electricity. Over 3 years, that’s about 50 × 36 + 1,000 = 3,000 USD to buy the robot and use it with only 1 app, or 3 USD every day. Let’s take as a reference the lowest possible minimum wage in London, the one for apprentices, which is about 5 USD per hour. This means that for the robot investment to breakeven, it’s enough to have the robot automate just 36 minutes worth of tasks a day! With the 2022 15 USD minimum wage in California, this goes down to 12 minutes! Personally I’m very excited by the role that they will play in removing repetitive tasks in our kitchens, lowering the cost of preparing food and increasing consistency without compromising on food quality. The first deployments will be in commercial kitchens, including dark kitchens, cafeterias and restaurants, and then they will start entering the home kitchen market. For commercial kitchens this will be the second wave of robotics, as more expensive collaborative robots are starting to enter kitchens as we speak, given that their economics are viable today. I may cover this topic in a future blog post. Inside our homes they will take on tasks like washing machine load/unloading, clothes folding, laundries and overall home clean-up. There are multiple ways for manipulators to be able to move to different places, including being mounted on mobile bases and rails, but I believe we will see very low tech solutions get traction first: small fixed bases where the robot can clamp and get power, after being physically moved there by the owner (a “robot charger”?). Other areas that will be impacted by low cost robots include areas with repetitive manual actions like laboratories, hospitals, agriculture, packaging, light manufacturing and remote areas which require infrequent manual intervention. We will also see completely novel applications in the area of communication (“physical” zoom calls!?), remote work and entertainment. I want to stress that all these use cases are very price sensitive, so it’s really the ability of robot manufacturers to offer very low cost that will enable this ecosystem to start blossoming. I see the low cost coming from four main sources: Lowering of all the specs that makes current collaborative robots overqualified. The decoupling of selling hardware vs selling the final use case. New revenue streams: app-store fees, data-mining, new advertisement channels. Robotic-as-a-Service business models, that is other revenue streams in the form of support, maintenance, upselling. Where we stand and what to expect next Let’s start from the hardware, how far are we all from good-enough specs at a good price point? There is work to do, but we are getting there. This is an early stage prototype that we built last year at Nyrvan (in 2 weeks, we didn’t tune the PID parameters much, which resulted in quite some shaking!) The 6 DOF cobot in the video could perform basic kitchen tasks, with a 1kg payload. We used carbon fiber tubes for the links, we 3D printed the joints structure in PLA (probably something with higher heat resistance would have been better), used an Arduino as computing unit and a 48V power supply. All these components can be bought cheaply on Amazon. The lion share of the bill of materials is taken by the actuators. We have chosen the servo brushless motors from Gyems model RMD-X7, RMD-X8 and RMD-X8 PRO, for about 2000 USD in total. Another option that we considered was T-Robot. In total we spent less than 2,500 USD to assemble a cobot, buying all the components at retail price. Actually bulk discounts are consistent for these robotic components, going up to 40%. As building hardware is not our focus, this was simply an excellent exercise in probing the future of robotics. During my research, I have discovered interesting projects and startups which look well equipped to offer or inspire these robotic platforms in the future. I’m going to cover a few of those here, but I’m surely missing many good ones. Please let me know about other promising projects in the comments! Project Blue from Berkeley’s Robot Learning Lab developed a Quasi-Direct Drive for Low-Cost Compliant Robotic Manipulation, which can be used for daily tasks such as folding clothes. They also included a manufacturing BoM estimate in the paper, in which they show they can bring the cost of the robot arm down to 1,250 USD, assuming 10.000 units sold. Elephant Robotics is selling myCobot which introduces the very interesting concept of selling small cobots with an integrated computing unit (a Raspberry Pi). The cobots can integrate with ROS and overall they tick many of the boxes of an iPhone of robotics. Innfos is another Chinese company, with a very interesting modular robotic arm, with amazing specs for less than 1,000 USD. Unfortunately, after a successful kickstarter campaign, they had internal issues and had to close the company. A shout out also to Skyentific 0 which runs a super thoughtful youtube channel on robotics. I spoke with him some time ago, he is really a cool guy and he is spreading a lot of knowledge on low cost robotic arms. Overall the area is still very niche and projects often have troubles going from early stage to growth stage: it’s hard to get funded, since there is a strong bias against hardware-heavy projects by angel investors and venture capitalists. Part of the problem is also due to the lack of demand, since in the past it was very hard to program collaborative robots and therefore hard and expensive to build actual products out of collaborative robots. Now, I would not say that today it’s easy to build robotic software (very often the best backend/frontend/devops practices are ignored in robotics, in which a good share of developers comes from an academic or mechanical/electronics background), but things are getting way more standardised and scalable thanks to standards like the Robotic Operating System and large pretrained computer vision models. Advancement in AI models applied to control and manipulation are also opening up dynamic use-cases like pick-and-place of arbitrary objects. Regarding a proper app store, it’s a chicken-egg issue, we will not see it until an affordable general-purpose cobot platform pops up. Also today there is a very small number of developers able to program these robots and they are employed by the companies selling vertically the use-case. So, what to expect next? We can expect the cost of the hardware to keep going down in the next few years, thanks to the increasing sales and the improving state of the software development cost. Tech directions to lower the cost of the cobots hardware also include: Using modular designs, therefore cutting down the cost of each degree of freedom thanks to economies of scale. Using gearless motors and other last gen motors to get rid of expensive force-torque sensors, brakes and harmonic gears. Using vision based control, to ease inverse kinematics and reduce the cost of position encoders and sensors. In terms of geography, all indications point to Chinese companies taking the lead in terms of development, at least regarding the hardware platform. The software situation is much more distributed. I think it would be nice to conclude this blogpost with an actual prediction, so here we go: If I had to guess the exact timeline, I would say that we will see a collaborative robot with the specs and price-point written above announced by the end of 2,026 so 5 years. I believe shortly after, say 1–2 years, we will see the first ecosystem approaches and the first cobots shipping with an app-store. What do you think? Let me know in the comments!

Sep 29, 2021

New method makes starch from CO₂ faster than plants can

Posted by in categories: chemistry, food, sustainability

Feeding the world uses enormous amounts of land, water, fertilizer, pesticide, and fuel. In a step towards a more sustainable solution, researchers have designed a method to make starches from carbon dioxide more efficiently than plants do (Science 2,021 DOI: 10.1126/science.abh4049).

The new technique, which relies on chemical catalysts and a curated combination of natural and engineered enzymes, converts CO2 to starch 8.5 times as efficiently as corn plants can.


The advance hints at sustainable, efficient factory production of food and industrial chemicals by.

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Sep 27, 2021

What Longevity Diet do Experts Eat?

Posted by in categories: food, life extension, lifeboat

We interviewed four longevity experts (including several Lifeboat Foundation board members) to learn how they think about their diets. I was particularly struck by how different they all were (except almost all of them fasted)!


Food.

In all our research into longevity so far, from quantifying how we sleep to exploring the science behind whether human life extension is possible, nutrition has remained the most controversial and confusing subject that we’ve covered. For example, when we surveyed 101 of our readers on their longevity diet, we got 101 very different answers. There is little consensus on what the perfect life extension diet should look like.

Sep 25, 2021

Does eating healthy prevent people from getting, dying from COVID?

Posted by in categories: biotech/medical, food, information science

We know that a daily diet that includes lots of fruit and vegetables is healthier, but now it seems that it can also help prevent one from being infected with COVID-19.

A new study from Boston published in the journal Gut reports that consuming healthy food like produce may lower the risk of contracting the virus, in addition to lowering the severity of symptoms if one is infected. Although doctors have stated that metabolic conditions including obesity and type 2 diabetes can cause severe coronavirus complications, this study is among the first to add nutrition to the equation.


A new study claims that one-third of coronavirus cases could have been avoided if people had healthier eating habits.

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Sep 24, 2021

Tomato is first CRISPR-edited food to go on sale in the world

Posted by in categories: biotech/medical, food

A tomato with higher levels of a nutrient linked to reduced stress can now be bought in Japan – it is the first CRISPR-edited food in the world to be launched commercially.

Sep 24, 2021

Machine learning uncovers ‘genes of importance’ in agriculture and medicine

Posted by in categories: biotech/medical, food, health, robotics/AI

“We show that focusing on genes whose expression patterns are evolutionarily conserved across species enhances our ability to learn and predict ‘genes of importance’ to growth performance for staple crops, as well as disease outcomes in animals,” explained Gloria Coruzzi, Carroll & Milton Petrie Professor in NYU’s Department of Biology and Center for Genomics and Systems Biology and the paper’s senior author.


Machine learning can pinpoint “genes of importance” that help crops to grow with less fertilizer, according to a new study published in Nature Communications. It can also predict additional traits in plants and disease outcomes in animals, illustrating its applications beyond agriculture.

Using to predict outcomes in agriculture and medicine is both a promise and challenge for . Researchers have been working to determine how to best use the vast amount of genomic data available to predict how organisms respond to changes in nutrition, toxins, and pathogen exposure—which in turn would inform crop improvement, disease prognosis, epidemiology, and public health. However, accurately predicting such complex outcomes in agriculture and medicine from genome-scale information remains a significant challenge.

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Sep 23, 2021

Mice Treated with This Cytokine Lose Weight

Posted by in categories: biotech/medical, food

PHILADELPHIA – Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Science from researchers in the Perelman School of Medicine at the University of Pennsylvania. Unexpectedly, the fat loss was not associated with decreased food intake or faster metabolism. Instead, the researchers discovered that TSLP stimulated the immune system to release lipids through the skin’s oil-producing sebaceous glands.

“This was a completely unforeseen finding, but we’ve demonstrated that fat loss can be achieved by secreting calories from the skin in the form of energy-rich sebum,” said principal investigator Taku Kambayashi, MD, PhD, an associate professor of Pathology and Laboratory Medicine at Penn, who led the study with fourth-year medical student Ruth Choa, PhD. “We believe that we are the first group to show a non-hormonal way to induce this process, highlighting an unexpected role for the body’s immune system.”

The animal model findings, Kambayashi said, support the possibility that increasing sebum production via the immune system could be a strategy for treating obesity in people.

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