Lifeboat Foundation

April 2020

The COVID-19 pandemic caused by SARS-CoV-2 has brought about an unprecedented crisis, taking a heavy toll on human health, lives as well as the global economy. There are no SARS-CoV-2-specific treatments or vaccines available due to the novelty of this virus. Hence, rapid development of effective vaccines against SARS-CoV-2 is urgently needed. Here we developed a pilot-scale production of a purified inactivated SARS-CoV-2 virus vaccine candidate (PiCoVacc), which induced SARS-CoV-2-specific neutralizing antibodies in mice, rats and non-human primates. These antibodies potently neutralized 10 representative SARS-CoV-2 strains, indicative of a possible broader neutralizing ability against SARS-CoV-2 strains circulating worldwide. Immunization with two different doses (3μg or 6 μg per dose) provided partial or complete protection in macaques against SARS-CoV-2 challenge, respectively, without any antibody-dependent enhancement of infection. Systematic evaluation of PiCoVacc via monitoring clinical signs, hematological and biochemical index, and histophathological analysis in macaques suggests that it is safe. These data support the rapid clinical development of SARS-CoV-2 vaccines for humans.

One Sentence Summary A purified inactivated SARS-CoV-2 virus vaccine candidate (PiCoVacc) confers complete protection in non-human primates against SARS-CoV-2 strains circulating worldwide by eliciting potent humoral responses devoid of immunopathology.

The authors have declared no competing interest.

Dinorah Delphin has unveiled another magnificent issue of the Immortalists Magazine. She has clearly focused her contributing authors on the world pandemic, with impressive results.

One of the outstanding articles is from our pal, the Chairman of the USTP, Gennady Stolyarov. Gennady levels an eviscerating attack on the American health care system.

I can see that Gennady has a visceral reaction to mass death. There is passionate, broiling anger in the lines of his article. He seems to be mounting a crusade, and I’m going to confess that I’m considering arming myself for battle.

Continue reading “IMMORTALISTS MAGAZINE’s 4th PUBLICATION!” »

The economic impact of the coronavirus pandemic has governments struggling with how to restart a global economy that has come to a grinding halt. Some short term needs have to be addressed as soon as possible — avoiding starvation, extending unemployment benefits, and arranging for emergency healthcare for those infected. But even as the world faces such daunting tasks, decisions made today will have enormous consequences for the future. While the emergency today is great, a much bigger emergency waits just around the corner as the Earth continues to overheat.

Governments in thrall to fossil fuel interests, such as the United States, see the virus as a chance to roll back advances in renewable energy. After all, the oil and gas industries provide for 10,000,000 jobs around the world. Surely those jobs must be protected, right?

Alibaba’s founder Jack Ma said on Friday in a virtual interview with China Media Group that under the current situation of COVID-19, the internet economy is supporting the world and the internet is the technology of the future.

“No country or enterprises can be isolated from the internet,” Ma said, adding that every one of us must grasp the future and improve the country’s economic system through future technologies and ideas.

The main route of transmission of SARS CoV infection is presumed to be respiratory droplets. However the virus is also detectable in other body fluids and excreta. The stability of the virus at different temperatures and relative humidity on smooth surfaces were studied. The dried virus on smooth surfaces retained its viability for over 5 days at temperatures of 22–25°C and relative humidity of 40–50%, that is, typical air-conditioned environments. However, virus viability was rapidly lost (3 log₁₀) at higher temperatures and higher relative humidity (e.g., 38°C, and relative humidity of 95%). The better stability of SARS coronavirus at low temperature and low humidity environment may facilitate its transmission in community in subtropical area (such as Hong Kong) during the spring and in air-conditioned environments. It may also explain why some Asian countries in tropical area (such as Malaysia, Indonesia or Thailand) with high temperature and high relative humidity environment did not have major community outbreaks of SARS.

Severe acute respiratory syndrome (SARS), was a new emerging disease associated with severe pneumonia and spread to involve over 30 countries in 5 continents in 2003. A novel coronavirus was identified as its cause [1–3]. SARS had a dramatic impact on health care services and economies of affected countries, and the overall mortality rate was estimated to be 9%, but rising to 50% in those aged 60 or above [4]. A notable feature of this disease was its predilection for transmission in the health care setting and to close family and social contacts. The disease is presumed to be spread by droplets, close direct or indirect contact, but the relative importance of these routes of transmission is presently unclear. A study showed that viral aerosol generation by a patient with SARS was possible and therefore airborne droplet transmission was a possible means of transmission [5].

#Hackers are seeking to exploit the roll-out of government financial relief plans to fill their own pockets at the expense of businesses and affected workers, Israeli cyber researchers have revealed.

Hackers are exploiting the rollout of governmental financial relief to fill their pockets at the expense of businesses and affected workers, according to Israeli cyber researchers.

In recent weeks, governments have sought to ease cash-flow shortages and avoid a recession with ambitious stimulus packages and grants to households, including a massive $2 trillion economic package in the United States.

Continue reading “Israeli researchers: Hackers aiming to exploit government financial aid” »

“People usually say they want a human element to their interactions but Covid-19 has changed that,” says Martin Ford, a futurist who has written about the ways robots will be integrated into the economy in the coming decades.

“[Covid-19] is going to change consumer preference and really open up new opportunities for automation.”

Robot workers can help us keep social distance but once machines take over it will be hard to go back.

The Black Death (1347−1350) was a pandemic that devastated the populations of Europe and Asia. The plague was an unprecedented human tragedy in Italy. It not only shook Italian society but transformed it. The Black Death marked an end of an era in Italy, its impact was profound, and it resulted in wide-ranging social, economic, cultural and religious changes.^[1] These changes, directly and indirectly, led to the emergence of the Renaissance, one of the greatest epochs for art, architecture, and literature in human history.

The Impact of the Plague of Italy

To Black Death spread to Italy from modern-day Russia. Genoese merchants spread the plague while fleeing a Mongol attack on their trading post in Crimea. The plague was carried and spread by the fleas that lived on the Black Rat and brought to Italy on the Genoese ships.^[2] The population of Italy was ill prepared for the spread of the disease. There had been a series of famine and food shortages in the region, and the population was weak and vulnerable to disease, and furthermore, the population did not have any natural resistance to the disease. Italy was the most urbanized society in Europe, Milan, Rome, Florence, and other Italian centers among the largest on the continent.^[3].

Europe’s largest steel mill is in the city of Taranto in southern Italy. In its heyday, the ILVA steel plant produced more than 10 million tons of steel every year—about 40 percent of all the steel made in Italy—and it currently employs about 12,000 people.

This is no small deal in an area where unemployment is north of 20 percent; indeed, the local economy of Taranto, population 200,000, is almost entirely dependent on the steel mill —which is also one of the biggest and most deadly polluters of anywhere in the Mediterranean.

The plant is a notorious source of dioxin, and dust from the plant is believed to be the reason why Taranto has a lung cancer rate 30 percent higher than the national average. It’s so toxic that farmers have been forbidden from raising livestock within a 20-kilometer radius of the plant; in 2008, the government ordered the slaughter of thousands of sheep and other animals that were found to have excessively high levels of dioxin.