Lifeboat Foundation

Venki Ramakrishnan’s is the real-deal ‘pivot story’ — ‘pivoting’ being quite the fancy thing to do today. Born in Chidambaram in Tamil Nadu in 1952, Venki wanted to be a physicist, and by the time he decided to do something about his passion for Biology, he was already a PhD in Physics from Ohio University, USA. He then ‘pivoted’ and studied Biology at the University of California, San Diego, before he began his post-doctoral work at Yale University.

He went on to win the Nobel Prize in Chemistry in 2009 for his work on cellular particles called ribosomes. His first book, Gene Machine, captures this journey with the kind of honesty and self-deprecation one does not expect from an award-winning scientist.

With similar candour, in his second book, he examines recent scientific breakthroughs in longevity and ageing and raises uncomfortable questions about the ethical aspects of the research as well as the biological purpose of death.

I found this on NewsBreak: Scientists Discover Potential Interstellar Origins of Life on Earth.

Manganese complexes have long been utilized by nature to catalyze the oxygen evolution reaction (OER) but mirroring their efficiency in artificial electrochemical systems has proven difficult. This study centers on alpha-manganese dioxide (α-MnO2), which closely mimics natural MnIV-O-MnIII-HxO motifs, presenting a novel method for manipulating proton coupling within the OER process using an external electric field.

Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time. The proteins of the formin family are pivotal partners in this process: positioned at the filament end, formins recruit new actin subunits and stay associated with the end by ‘stepping’ with the growing filament.

There are as many as 15 different formins in our cells that drive actin filament growth at different speeds and for different purposes. Yet, the exact mechanism of action of formins and the basis for their different inherent speeds have remained elusive. Now, for the first time, researchers from the groups of Stefan Raunser and Peter Bieling at the Max Planck Institute of Molecular Physiology in Dortmund have visualized at the molecular level how formins bind to the ends of actin filaments.

This allowed them to uncover how formins mediate the addition of new actin molecules to a growing filament. Furthermore, they elucidated the reasons for the different speeds at which the different formins promote this process. The MPI researchers used a combination of biochemical strategies and electron cryo-microscopy (cryo-EM). The breakthrough, published in the journal Science, can help us explain why certain mutations in formins can lead to neurological, immune, and cardiovascular diseases.

Researchers at the University of Colorado Boulder have developed experiments to replicate the chemical reactions of the Interstellar Medium, using techniques like laser cooling and mass spectrometry to observe interactions between ions and molecules.

While it may not look like it, the interstellar space between stars is far from empty. Atoms, ions, molecules, and more reside in this ethereal environment known as the Interstellar Medium (ISM). The ISM has fascinated scientists for decades, as at least 200 unique molecules form in its cold, low-pressure environment. It’s a subject that ties together the fields of chemistry, physics, and astronomy, as scientists from each field work to determine what types of chemical reactions happen there.

Now, in the recently published cover article of the Journal of Physical Chemistry A, JILA Fellow and University of Colorado Boulder Physics Professor Heather Lewandowski and former JILA graduate student Olivia Krohn highlight their work to mimic ISM conditions by using Coulomb crystals, a cold pseudo-crystalline structure, to watch ions and neutral molecules interact with each other.

In a study recently published in Nature, researchers from the Max Born Institute in Berlin, Germany, and the Max-Planck Institute of Quantum Optics in Garching have unveiled a new technique for deciphering the properties of matter with light, that can simultaneously detect and precisely quantify many substances with a high chemical selectivity.

Their technique interrogates the atoms and molecules in the ultraviolet spectral region at very feeble light levels. Using two optical frequency combs and a photon counter, the experiments open up exciting prospects for conducting dual-comb spectroscopy in low-light conditions and they pave the way for novel applications of photon-level diagnostics, such as precision spectroscopy of single atoms or molecules for fundamental tests of physics and ultraviolet photochemistry in the Earth’s atmosphere or from space telescopes.

Scientists in Cambridge University suggest molecules, vital to the development of life, could have formed from a process known as graphitization. Once verified in the laboratory, it could allow us to try and recreate plausible conditions for life’s emergence.

How did the chemicals required for life get there? It has long been debated how the seemingly fortuitous conditions for life arose in nature, with many hypotheses reaching dead ends. However, researchers at the University of Cambridge have now modeled how these conditions could occur, producing the necessary ingredients for life in substantial quantities.

Life is governed by molecules called proteins, phospholipids and nucleotides. Past research suggests that useful molecules containing nitrogen like nitriles—cyanoacetylene(HC₃N) and hydrogen cyanide (HCN)—and isonitriles—isocyanide(HNC) and methyl isocyanide(CH₃NC)—could be used to make these building blocks of life. As of yet though, there has been no clear way to make all of these in the same environment in substantial amounts.

For the first time, scientists have managed to create sheets of gold only a single atom layer thick. The material has been termed goldene. According to researchers from Linköping University, Sweden, this has given the gold new properties that can make it suitable for use in applications such as carbon dioxide conversion, hydrogen production, and production of value-added chemicals. Their findings are published in the journal Nature Synthesis.

Scientists have long tried to make single-atom-thick sheets of gold but failed because the metal’s tendency to lump together. But researchers from Linköping University have now succeeded thanks to a hundred-year-old method used by Japanese smiths.

“If you make a material extremely thin, something extraordinary happens – as with graphene. The same thing happens with gold. As you know, gold is usually a metal, but if single-atom-layer thick, the gold can become a semiconductor instead,” says Shun Kashiwaya, researcher at the Materials Design Division at Linköping University.

Cannabinol (CBN) is a chemical found in cannabis that exhibits milder psychoactive properties than most cannabis chemicals, though research pertaining to its medical applications remains limited. Now, a team of researchers led by The Salk Institute for Biological Studies have published a study in Redox Biology that addresses the potential for CBN to serve as a method for neurological disorders, including traumatic brain injuries, Parkinson’s disease, and Alzheimer’s disease.

For the study, the researchers produced four CBN analogs that exhibited greater neuroprotective capabilities compared to the traditional CBN molecule and tested them on Drosophila fruit flies. In the end, the researchers discovered these CBN analogs possessed neuroprotective capabilities that surpassed traditional CBN molecules, including the treating of traumatic brain injuries. While not tested during this study, these CBN analogs could be used to also treat a myriad of neurological disorders, including Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease.

“Our findings help demonstrate the therapeutic potential of CBN, as well as the scientific opportunity we have to replicate and refine its drug-like properties,” said Dr. Pamela Maher, who is a research professor in the Cellular Neurobiology Laboratory at Salk and a co-author on the study. “Could we one day give this CBN analog to football players the day before a big game, or to car accident survivors as they arrive in the hospital? We’re excited to see how effective these compounds might be in protecting the brain from further damage.”