Lifeboat Foundation

It has long been understood that a parent’s DNA is the principal determinant of health and disease in offspring. Yet inheritance via DNA is only part of the story; a father’s lifestyle such as diet, being overweight and stress levels have been linked to health consequences for his offspring. This occurs through the epigenome—heritable biochemical marks associated with the DNA and proteins that bind it. But how the information is transmitted at fertilization along with the exact mechanisms and molecules in sperm that are involved in this process has been unclear until now.

A new study from McGill, published recently in Developmental Cell, has made a significant advance in the field by identifying how environmental information is transmitted by non-DNA molecules in the sperm. It is a discovery that advances scientific understanding of the heredity of paternal life experiences and potentially opens new avenues for studying disease transmission and prevention.

Graph representations can solve complex problems in natural science, as patterns of connectivity can give rise to a magnitude of emergent phenomena. Graph-based approaches are specifically important during quantum communication, alongside quantum search algorithms in highly branched quantum networks. In a new report now published on Science Advances, Max Ehrhardt and a team of scientists in physics, experimental physics and quantum science in Germany introduced a hitherto unidentified paradigm to directly realize excitation dynamics associated with three-dimensional networks. To accomplish this, they explored the hybrid action of space and polarization degrees of freedom of photon pairs inside complex waveguide circuits. The team experimentally explored multiparticle quantum walks on complex and highly connected graphs as testbeds to pave the way to explore the potential applications of fermionic dynamics in integrated photonics.

Complex networks

Complex networks can occur across diverse fields of science, ranging from biological signaling pathways and biochemical molecules to exhibit efficient energy transport to neuromorphic circuits across to social interactions across the internet. Such structures are typically modeled using graphs whose complexity relies on the number of nodes and linkage patterns between them. The physical representation of a graph is limited by their requirement for arrangement in three-dimensional (3D) space. The human brain is a marked example of scaling behavior that is unfavorable for physical simulation due to its staggering number of 80 billion neurons, dwarfed by 100 trillion synapses that allow the flow of signals between them. Despite the number of comparably miniscule volume of nodes, discrete quantum systems faced a number of challenges owing to complex network topologies, efficient multipartite quantum communications and search algorithms.

Researchers at Duke University have revealed long-hidden molecular dynamics that provide desirable properties for solar energy and heat energy applications to an exciting class of materials called halide perovskites.

A key contributor to how these materials create and transport electricity literally hinges on the way their atomic lattice twists and turns in a hinge-like fashion. The results will help materials scientists in their quest to tailor the chemical recipes of these materials for a wide range of applications in an environmentally friendly way.

The results appear online March 15 in the journal Nature Materials.

The sounds of 30 impacts are heard, some slightly louder than others, said NASA in its press release. SuperCam, equipped with a microphone, is using the laser to interrogate the composition of rock on the red planet. The variations in the zapping sound picked up the equipment would help the scientists in understanding the physical structure of the rocks and is a key component in probing the signs of ancient life.

“Variation in the intensity of the zapping sounds will provide information on the physical structure of the targets, such as its relative hardness or the presence of weathering coatings,” said NASA.

Continue reading “NASA shares first recording of Perseverance firing its laser on Mars” »

University of Chicago researchers hunt for proposed particles that could explain quirks of the universe.

A team of researchers at the University of Chicago recently embarked on the search of a lifetime—or rather, a search for the lifetime of long-lived supersymmetric particles.

Supersymmetry is a proposed theory to expand the Standard Model of particle physics. Akin to the periodic table of elements, the Standard Model is the best description we have for subatomic particles in nature and the forces acting on them.

When it comes to microelectronics, there is one chemical element like no other: silicon, the workhorse of the transistor technology that drives our information society. The countless electronic devices we use in everyday life are a testament to how today very high volumes of silicon-based components can be produced at very low cost. It seems natural, then, to use silicon also in other areas where the properties of semiconductors—as silicon is one—are exploited technologically, and to explore ways to integrate different functionalities. Of particular interest in this context are diode lasers, such as those employed in barcode scanners or laser pointers, which are typically based on gallium arsenide (GaAs). Unfortunately though, the physical processes that create light in GaAs do not work so well in silicon. It therefore remains an outstanding, and long-standing, goal to find an alternative route to realizing a ‘laser on silicon.’

Writing today in Applied Physics Letters, an international team led by Professors Giacomo Scalari and Jérôme Faist from the Institute for Quantum Electronics present an important step towards such a device. They report electroluminescence—electrical light generation—from a semiconductor structure based on silicon-germanium (SiGe), a material that is compatible with standard fabrication processes used for silicon devices. Moreover, the emission they observed is in the terahertz frequency band, which sits between those of microwave electronics and infrared optics, and is of high current interest with a view to a variety of applications.

Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published on March 22021, in Nature Communications, the researchers modified E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.

Genetically engineered E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules — called sulfated glycosaminoglycans — that are often used as drugs and nutraceuticals…

“It’s a challenge to engineer E. coli to produce these molecules, and we had to make many changes and balance those changes so that the bacteria will grow well,” said Mattheos Koffas, lead researcher and a professor of chemical and biological engineering at Rensselaer Polytechnic Institute. “But this work shows that it is possible to produce these polysaccharides using E. coli in animal-free fashion, and the procedure can be extended to produce other sulfated glycosaminoglycans.”

Columbia researchers engineer first technique to exploit the tunable symmetry of 2D materials for nonlinear optical applications, including laser, optical spectroscopy, imaging, and metrology systems, as well as next-generation optical quantum information processing and computing.

Nonlinear optics, a study of how light interacts with matter, is critical to many photonic applications, from the green laser pointers we’re all familiar with to intense broadband (white) light sources for quantum photonics that enable optical quantum computing, super-resolution imaging, optical sensing and ranging, and more. Through nonlinear optics, researchers are discovering new ways to use light, from getting a closer look at ultrafast processes in physics, biology, and chemistry to enhancing communication and navigation, solar energy harvesting, medical testing, and cybersecurity.

Columbia Engineering researchers report that they developed a new, efficient way to modulate and enhance an important type of nonlinear optical process: optical second harmonic generation — where two input photons are combined in the material to produce one photon with twice the energy — from hexagonal boron nitride through micromechanical rotation and multilayer stacking. The study was published online on March 32021, by Science Advances.

Researchers at the University of California San Diego (UCSD) have developed a wearable health monitor that may bring us one step closer to the dream of Star Trek’s famous tricorder.

The monitor, a stretchy skin patch, can do it all: measuring blood pressure and heart rate, your glucose levels, as well as one of alcohol, caffeine, or lactate levels.

According to UCSD’s press release, the patch is the first device to demonstrate measuring multiple biochemical and cardiovascular signals at the same time.