Lifeboat Foundation

PHILADELPHIA – Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Science from researchers in the Perelman School of Medicine at the University of Pennsylvania. Unexpectedly, the fat loss was not associated with decreased food intake or faster metabolism. Instead, the researchers discovered that TSLP stimulated the immune system to release lipids through the skin’s oil-producing sebaceous glands.

“This was a completely unforeseen finding, but we’ve demonstrated that fat loss can be achieved by secreting calories from the skin in the form of energy-rich sebum,” said principal investigator Taku Kambayashi, MD, PhD, an associate professor of Pathology and Laboratory Medicine at Penn, who led the study with fourth-year medical student Ruth Choa, PhD. “We believe that we are the first group to show a non-hormonal way to induce this process, highlighting an unexpected role for the body’s immune system.”

The animal model findings, Kambayashi said, support the possibility that increasing sebum production via the immune system could be a strategy for treating obesity in people.

DeepMind has given 3D structure to 350,000 proteins, including every one made by humans, promising a boon for medicine and drug design.

The size of a grain of sand, dispersed microfliers could monitor air pollution, airborne disease, and environmental contamination.

Northwestern University engineers have added a new capability to electronic microchips: flight.

Continue reading “Winged Microchip Is Smallest-Ever Human-Made Flying Structure — The Size of a Grain of Sand” »

Microglia immune cells can join together to form networks when needed, a new study reports. However, certain mutations associated with Parkinson’s disease can impair this process.

Is an academic doctor and medical technology entrepreneur, working in the field of the computational biology of aging.

Dr. Radenkovic is also a Partner at the SALT Bio-Fund, and a co-founder of Hooke, an elite longevity research clinic in London.

Continue reading “Dr. Dina Radenkovic, MD — Longevity Physician, Med-Tech Entrepreneur, Thought Leader, Financier” »

Bacteria may get a bad reputation in general, yet it’s actually generally healthy and serves an important role in many habitats, including human bodies. From supporting life on Earth to being employed in industrial and medicinal processes, bacteria have their figurative fingers in many pots — some varieties of bacteria can even filter tainted water and make it safe for human consumption.

A team of researchers from the Indian Institute of Technology, Banaras Hindu University (IIT-BHU) has found a bacteria that can do just that — Named “microbacterium paraoxydans strain VSVM IIT (BHU)” by the scientists, it can separate toxic hexavalent chromium from water in an effective and eco-friendly manner, according to a research published in the Journal of Environmental Chemical Engineering.

Hexavalent chromium is a heavy metal ion that is used in electroplating, welding, and chromate painting, among other things. It’s said to be responsible for health problems in humans like cancers, kidney and liver malfunctioning, and infertility. When compared to current approaches, the scientists believe that this bacterial strain, which can tolerate high amounts of hexavalent chromium, is particularly successful at eliminating the harmful substance from wastewater.

Advocates of the fat-but-fit approach to obesity treatment argue that improving fitness, even in the absence of weight loss, can help reduce the risk of cardiovascular disease and mortality.

New research suggests that improving fitness is at least as effective as weight loss for staving off obesity-related cardiovascular disease and mortality risks.

From ecosystem development to talent, much effort is still required for practical implementation of edge AI.

By Pushkar Apte and Tom Salmon

Rapid advances in artificial intelligence (AI) have made this technology important for many industries, including finance, energy, healthcare, and microelectronics. AI is driving a multi-trillion-dollar global market while helping to solve some tough societal problems such as tracking the current pandemic and predicting the severity of climate-driven events like hurricanes and wildfires.

Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain-and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro-or anti-cancer YAP activity functionally defines binary YAPon or YAPoff cancer classes that express or silence YAP, respectively. YAPoff solid cancers are neural/neuroendocrine and frequently RB1−/−, such as retinoblastoma, small cell lung cancer, and neuroendocrine prostate cancer. YAP silencing is intrinsic to the cell of origin, or acquired with lineage switching and drug resistance. The binary cancer groups exhibit distinct YAP-dependent adhesive behavior and pharmaceutical vulnerabilities, underscoring clinical relevance. Mechanistically, distinct YAP/TEAD enhancers in YAPoff or YAPon cancers deploy anti-cancer integrin or pro-cancer proliferative programs, respectively. YAP is thus pivotal across cancer, but in opposite ways, with therapeutic implications.

Pearson et al. demonstrate that YAP/TAZ, well-known oncogenes, are tumor suppressors in a large group of cancers. Pan-cancer analyses reveal that opposite YAP/TAZ expression, adhesive behavior, and oncogenic versus tumor suppressor YAP/TAZ activity functionally stratify binary cancer classes, which interchange to drive drug resistance. Contrasting YAPoff/YAPon classes exhibit unique vulnerabilities, facilitating therapeutic selection.