Lifeboat Foundation

Why do cells, and by extension humans, age? The answer may have a lot to do with mitochondria, the organelles that supply cells with energy. Though that idea is not new, direct evidence in human cells had been lacking. Until now.

In a study published Jan. 12 in Communications Biology, a team led by Columbia University researchers has discovered that human cells with impaired mitochondria respond by kicking into higher gear and expending more energy. While this adaptation—called hypermetabolism—enhances the cells’ short-term survival, it comes at a high cost: a dramatic increase in the rate at which the cells age.

“The findings were made in cells from patients with rare mitochondrial diseases, yet they may also have relevance for other conditions that affect mitochondria, including neurodegenerative diseases, inflammatory conditions, and infections,” says principal investigator Martin Picard, PhD, associate professor of behavioral medicine (in psychiatry and neurology) at Columbia University Vagelos College of Physicians and Surgeons.

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Bristle Discount Link (Oral Microbiome Quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Continue reading “Blood Test #7 in 2022: Diet Composition” »

Excessive fear is a hallmark of anxiety disorders, a major cause of disease burden worldwide. Substantial evidence supports a role of prefrontal cortex-amygdala circuits in the regulation of fear and anxiety, but the molecular mechanisms that regulate their activity remain poorly understood. Here, we show that downregulation of the histone methyltransferase PRDM2 in the dorsomedial prefrontal cortex enhances fear expression by modulating fear memory consolidation. We further show that Prdm2 knock-down (KD) in neurons that project from the dorsomedial prefrontal cortex to the basolateral amygdala (dmPFC-BLA) promotes increased fear expression. Prdm2 KD in the dmPFC-BLA circuit also resulted in increased expression of genes involved in synaptogenesis, suggesting that Prdm2 KD modulates consolidation of conditioned fear by modifying synaptic strength at dmPFC-BLA projection targets.

The battery resolves a longstanding technological issue that no other battery design has ever addressed.

Micro batteries have the incredible potential to power microdevices, microrobots, and implantable medical devices. However, up to recently they have not been very efficient as they lacked power.

Unlocking the potential of smaller devices.

Continue reading “Researchers create microbattery that could power insect-sized robots” »

Rasi Bhadramani/iStock.

Now, an artificial pancreas also called a closed-loop system, may provide relief for people with type 1 diabetes, according to a post on BMJ published on Tuesday.

High blood pressure is a modifiable risk factor for heart disease and contributes about $131 billion annually to the cost of healthcare services, according to the Centers for Disease Control and Prevention. In a study from Yale University, scientists found a potential target for the development of high blood pressure drugs.

https://www.youtube.com/watch?v=oMc3EFUH4Z0

Looking at Parkinson’s for what it really is and where we need to learn more.

Moderator — Ben Stecher, Parkinson’s Advocate.

Continue reading “What Do Researchers Really Mean When They Say ‘Cure’ (exploding the myths)” »

We take a look at and why some researchers think it could be useful in combating aging.

Rapamycin is a macrolide, a class of antibiotic that includes erythromycin, roxithromycin, azithromycin, and clarithromycin. exhibits potent antitumor and immunosuppressive activity.

Where is found?

Aging is characterized by changes in cellular identity and function over time. This process is driven by changes in chromatin factor localization during DNA break repair, which alters the epigenome and advances the epigenetic clock. Expression of a subset of Yamanka factors, OSK, can reverse these changes and modulate aging.