Lifeboat Foundation

A research team from the Chinese Academy of Sciences (CAS) and BGI Research has unveiled the complex mechanisms through which immunoglobulins impact the aging process, a discovery that could transform our understanding of aging.

This research, published in Cell on November 4, not only charts a high-precision map of aging across various organs but also reveals the dual-edged sword of immunoglobulins in systemic aging.

The quest for systemic biomarkers and key drivers of aging has been a long-standing puzzle in the field of gerontology. This study, a collaborative effort between Guanghui Liu’s team from the Institute of Zoology (IOZ) of CAS, Ying Gu’s team from BGI Research, Weiqi’s Zhang team from the Beijing Institute of Genomics of CAS, and Jing Qu’s team also from IOZ, has provided compelling answers.

A new, more sustainable AI model recognizes visual scenes by mirroring brain processes, opening doors for applications in medical diagnostics, drug discovery and beyond.

‘Are you a mind with a body or a body with a mind?’ The legacy of a 1970 ‘head transplant’ experiment performed on monkeys.

A new study reveals a ‘nano-switch’ in ferredoxin that affects its electron transfer, which could lead to advancements in sensors and drug development.

Researchers in Japan have discovered a mechanism for controlling the potential of an “electron carrier” protein in the redox reaction that all organisms need to obtain energy. Through experiments, the precise 3D structure of the protein, including hydrogen atoms, was determined, and theoretical calculations using this data visualized the electronic structure of the iron-sulfur cluster.

The results revealed, for the first time, that the electric potential of the iron-sulfur cluster changes dramatically depending on the presence or absence of a single hydrogen atom at an amino acid side chain, a so-called “nano-switch” mechanism. This research, recently published in the journal eLife, not only deepens our scientific understanding of biological reactions but also provides crucial insights for the future development of ultra-sensitive sensors for oxygen and nitric oxide, as well as novel drugs.

Nature Medicine asks leading researchers to name their top clinical trial for 2025, from gene therapies for prion disease and sickle-cell disease to digital tools for cancer and mental health.

As an emerging new class, metal nanoparticles and especially silver nanoparticles hold great potential in the field of cancer biology. Due to cancer-specific targeting, the consequently attenuated side-effects and the massive anti-cancer features render nanoparticle therapeutics desirable platforms for clinically relevant drug development. In this review, we highlight those characteristics of silver nanoparticle-based therapeutic concepts that are unique, exploitable, and achievable, as well as those that represent the critical hurdle in their advancement to clinical utilization. The collection of findings presented here will describe the features that distinguish silver nanoparticles from other anti-cancer agents and display the realistic opportunities and implications in oncotherapeutic innovations to find out whether cancer therapy by silver nanoparticles is fiction or reality.

Lipids, together with lipoprotein particles, are the cause of atherosclerosis, which is a pathology of the cardiovascular system. In addition, it affects inflammatory processes and affects the vessels and heart. In pharmaceutical answer to this, statins are considered a first-stage treatment method to block cholesterol synthesis. Many times, additional drugs are also used with this method to lower lipid concentrations in order to achieve certain values of low-density lipoprotein (LDL) cholesterol. Recent advances in photodynamic therapy (PDT) as a new cancer treatment have gained the therapy much attention as a minimally invasive and highly selective method. Photodynamic therapy has been proven more effective than chemotherapy, radiotherapy, and immunotherapy alone in numerous studies.

A new DNA analysis has shown that the arrival of modern humans from Africa was far from smooth.

It could lead to vaccines that could be simply rubbed onto the skin like creams.

Some bacteria, like harmless Staphylococcus epidermidis, have adapted to thrive on human skin.

Continue reading “Skin bacteria turned into topical vaccine, protects mice against tetanus” »