Lifeboat Foundation

The strength of genome-wide association studies (GWAS) lies in their ability to identify new disease biomarkers through large-scale genomic comparisons of afflicted individuals and unaffected controls. Now, using this powerful technique, an international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer—one of the most common cancers to affect women—taking the number of known gene regions associated with the disease to nine.

Endometrial cancer affects the lining of the uterus, typically presenting as an adenocarcinoma. Endometrial cancer is the sixth most common cancer in women worldwide and is the most common cancer of the female reproductive tract in developed countries, with over 320,000 new cases diagnosed in 2012.

Investigators at the University of Cambridge, Oxford University, and QIMR Berghofer Medical Research Institute in Brisbane studied the DNA of over 7000 women with endometrial cancer and 37,000 women without cancer to identify genetic variants that affected a woman’s risk of developing the disease.

Continue reading “Endometrial Cancer Genetic Risk Factors Double” »

The likelihood of giving birth to non-identical twins run in the families, suggests a new study conducted by a team of scientists. The team based their conclusion on the identification of two genetic variants in women who give birth to twins.

A number of factors have previously been linked to why some women give birth to non-identical twins. However, no study ever characterized the properties of the genes the contribute to this outcome.

The latest study looks at the genetic makeup of the mother and explains how mother’s genes can lead to the birth of non-identical twins. During the study, the research team specifically compared the genomes of the non-identical twins’ mothers to look for any common genetic variants between them.

Continue reading “Non-Identical Twins Run In Families: Scientists Find Common Genes” »

Nice

Neurosurgeons using lasers to treat brain cancer have discovered the technique breaks down the blood-brain barrier, a finding that could potentially lead to new treatment options for the deadly disease. Ben Gruber reports.

Gotta luv this.

An international team of researchers including the Lomonosov Moscow State University physicists has developed a completely new type of drug carrier for targeted delivery to the sick organ — the gel nano-capsules with a double shell. The results of the study were published in Scientific Reports.

This biotech company just got approval to try and bring clinically dead patients back to life.

http://www.telegraph.co.uk/science/2016/05/03/dead-could-be-…g-project/

Can we revive the dead?

This article originally appeared on Spectrum on May 2, 2016.

Very cool!

As we age, tiny blood vessels in the brain stiffen and sometimes rupture, causing “microbleeds.” This damage has been associated with neurodegenerative diseases and cognitive decline, but whether the brain can naturally repair itself beyond growing new blood-vessel tissue has been unknown. A zebrafish study published on May 3 in Immunity describes for the first time how white blood cells called macrophages can grab the broken ends of a blood vessel and stick them back together.

“Microbleeding occurs very often in the human brain, particularly in elderly people,” says Lingfei Luo, a developmental geneticist at Southwest University in China. “We believe that this macrophage behavior is the major cellular mechanism to repair ruptures of blood vessels and avoid microbleeding in the brain.”

To simulate a human brain microbleed, Luo and his colleagues shot lasers into the brains of live zebrafish to rupture small blood vessels, creating a clean split in the tissue with two broken ends. Then, the researchers used a specialized microscope to watch what happened next.

Cambridge’s new nano-scale light-powered piston engine that may one day energize devices to treat diseases directly or deliver drugs.

At the University of Cambridge researchers have developed a nano-scale light-powered piston engine that may one day energize devices to treat diseases directly or deliver drugs in powerful new ways. The device consists of charged gold nanoparticles within a polymer that bends and relaxes in response to heat changes. The polymer absorbs water when cooled, expanding in size, while heating the gold nanoparticles using a laser raises the temperature of the polymer, shedding the absorbed water and relaxing in response. This process happens in a fraction of a second, and as long as a laser is made to flip between being on and off, the engine keeps working.

According to the researchers, the force generated given the weight of the device is quite huge, at least a hundred times greater than existing motors or even muscle cells.

Continue reading “Scientists Develop Powerful Bio-Compatible Nano-Motor” »

A groundbreaking trial to see if it is possible to regenerate the brains of dead people, has won approval from health watchdogs.

A biotech company in the US has been granted ethical permission to recruit 20 patients who have been declared clinically dead from a traumatic brain injury, to test whether parts of their central nervous system can be brought back to life.

Scientists will use a combination of therapies, which include injecting the brain with stem cells and a cocktail of peptides, as well as deploying lasers and nerve stimulation techniques which have been shown to bring patients out of comas.

Continue reading “Dead could be brought ‘back to life’ in groundbreaking project” »