Sounds like new options to be considered around Polyhistidine Tagging.
Among bioprocessors, attitudes toward affinity purification range from a desire to move beyond old specificity/yield trade-offs to a willingness to explore new polyhistidine technology spin-offs, including systems for real-time detection.
Bad news if you use RoundUp.
Local councils across Australia that use the weed killer glyphosate on nature-strips and playgrounds are being warned that the chemical probably causes cancer.
An updated World Health Organisation (WHO) warning for the herbicide, often trade marked as Roundup, is also routinely used in household gardens and farms.
This could be very very tricky for a number of reasons: 1) how will this work with people who develop laryngitis or some other illness disrupting their speech? 2) what happens if a person uses a recorded voice or voice changer? 3) what happens when a person’s voice does change as they get older or have a medical procedure done that permanently alters the voice? I could list more; however, I believe that researcher will realize that there will be a need for two forms of biometrics when it comes to the voice.
Software firm Nuance believes that in the near future, there will be an expectation from customers to interact with technology in a more human-like manner.
Needle-free Nanopatch technology developed at The University of Queensland has been used to successfully deliver an inactivated poliovirus vaccine.
Delivery of a polio vaccine with the Nanopatch was demonstrated by UQ’s Professor Mark Kendall and his research team at UQ’s Australian Institute for Bioengineering and Nanotechnology, in collaboration with the World Health Organisation, the US Centres for Disease Control and Prevention, and vaccine technology company Vaxxas.
Professor Kendall said the Nanopatch had been used to administer an inactivated Type 2 poliovirus vaccine in a rat model.
The strangest life forms on Earth just got a lot stranger.
In 2003, Didier Raoult of Aix-Marseille University in France and his colleagues discovered a new kind of virus lurking inside single-celled protozoans.
Like other viruses, it couldn’t grow on its own, lacking the biochemical machinery to build proteins and genes. Instead, it had to infect host cells and use their material to produce new viruses.
Continue reading “These bizarre organisms could represent a new branch on the tree of life” »
New genetic technologies like CRISPR/Cas9 gene editing and synthetic biology are leading us to entirely new definitions of disease. Now “patients” include people who want children who lack some of their own genes, or have additional ones that they themselves lack. Also among the new patients are people who in the past were too old to have children as well some women who get sick from pregnancy and childbirth, or even the idea of them. Technological advances on the horizon may eventually offer treatment for such conditions.
In February 2015 the British Parliament approved production of “three-parent” children by transferring the nucleus of one woman’s egg into the nucleus-less (“enucleated”) egg of a second woman to avoid the propagation of certain rare “mitochondrial” diseases, Though there were acknowledged risks of the unprecedented procedure (including the possibility of producing novel birth defects), the argument that prevailed was that some mitochondrial diseases are so devastating that it should be tried in the narrowly defined group of prospective mothers carrying defective mitochondria.
Not long afterward, news articles began to appear discussing use of the technique for an entirely different purpose. The procedure’s inventor, the Oregon Health & Science University biologist Dr. Shoukhrat Mitalipov, was now proposing to treat infertility in older women by transferring their egg nuclei into the enucleated eggs of younger women.
Brown University engineers have developed a new technique to help researchers understand how cells move through complex tissues in the body. They hope the tool will be useful in understanding all kinds of cell movements, from how cancer cells migrate to how immune cells make their way to infection sites.
The technique is described in a paper published in the Proceedings of the National Academy of Sciences.
The traditional method for studying cell movement is called traction force microscopy (TFM). Scientists take images of cells as they move along 2-D surfaces or through 3-D gels that are designed as stand-ins for actual body tissue. By measuring the extent to which cells displace the 2-D surface or the 3-D gel as they move, researchers can calculate the forces generated by the cell. The problem is that in order to do the calculations, the stiffness and other mechanical properties of artificial tissue environment must be known.
Columbia University scientists recently tested a new optical technique to study how information is transmitted in the brains of mice and made a surprising discovery: When stimulated electrically to release dopamine (a neurotransmitter or chemical released by neurons, or nerve cells, to send signals to other nerve cells), only about 20 percent of synapses — the connections between cells that control brain activity — were active at any given time.
The effect had never been noticed. “Older techniques only revealed what was going on in large groups of synapses,” explained David Sulzer, PhD, professor of neurobiology in Psychiatry, Neurology, and Pharmacology at Columbia University Medical Center (CUMC). “We needed a way to observe the neurotransmitter activity of individual synapses, to help us better understand their intricate behavior.”
