Lifeboat Foundation

TRX-1 inhibitor TXNIP might be implicated in increased oxidative stress as we age.

According to scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, or DKFZ), the enzyme TXNIP, which inhibits the enzyme TRX-1, might be a regulator of aging and might be a viable candidate for future interventions against age-related diseases [1].

Study summary

Continue reading “Antioxidant inhibitor might be a regulator of aging” »

An international team of researchers have developed a low-cost sensor made from semiconducting plastic that can be used to diagnose or monitor a wide range of health conditions, such as surgical complications or neurodegenerative diseases.

The sensor can measure the amount of critical metabolites, such as lactate or glucose, that are present in sweat, tears, saliva or blood, and, when incorporated into a diagnostic device, could allow health conditions to be monitored quickly, cheaply and accurately. The new device has a far simpler design than existing sensors, and opens up a wide range of new possibilities for health monitoring down to the cellular level. The results are reported in the journal Science Advances.

The device was developed by a team led by the University of Cambridge and King Abdullah University of Science and Technology (KAUST) in Saudi Arabia. Semiconducting plastics such as those used in the current work are being developed for use in solar cells and flexible electronics, but have not yet seen widespread use in biological applications.

Continue reading “Low-cost plastic sensors could monitor a range of health conditions” »

This is the Freethink Dispatch, our rundown of the stories that mattered from the frontiers of a changing world. This week, engineers created brain-surgery robots that can work inside an MRI, scientists found a way to use coffee to treat diabetes, and a startup is making fresh produce that lasts twice as long. All that and more, plus a new episode of Freethink’s original hit series Superhuman about how doctors are reprogramming the immune system to kill untreatable cancers.

You didn’t think scientists would let IBM’s “world’s smallest computer” boast go unchallenged, did you? Sure enough, University of Michigan has produced a temperature sensing ‘computer’ measuring 0.04 cubic millimeters, or about a tenth the size of IBM’s former record-setter. It’s so small that one grain of rice seems gigantic in comparison — and it’s so sensitive that its transmission LED could instigate currents in its circuits.

The size limitations forced researchers to get creative to reduce the effect of light. They switched from diodes to switched capacitors, and had to fight the relative increase in electrical noise that comes from running on a device that uses so little power.

The result is a sensor that can measure changes in extremely small regions, like a group of cells in your body. Scientists have suspected that tumors are slightly hotter than healthy tissue, but it’s been difficult to verify this until now. The minuscule device could both check this claim and, if it proves true, gauge the effectiveness of cancer treatments. The team also envisions this helping to diagnose glaucoma from inside the eye, monitor biochemical processes and even study tiny snails.

Continue reading “World’s tiniest ‘computer’ makes a grain of rice seem massive” »

KrioRus charges $36,000 to cryonize a corpse, or half that for just the head. The process is fairly straightforward: First, cryonicists drain the blood of the “patient,” and pump in a solution resembling antifreeze. The body goes into a cooling chamber beneath KrioRus’s 2,000-square-foot hangar in Sergiyev Posad, a suburb north of Moscow, for roughly a week. Then it’s immersed, head first, in a double-walled dewar of liquid nitrogen, where it hangs indefinitely until scientists figure out how to revive it. In this way, KrioRus has cryopreserved 61 people and 31 pets, including a cat, a goldfinch, and a chinchilla. At least 487 others have signed up.

“Maybe in five, 30, or 300 years, there will be a way to wake her again,” Riabinina says.

Riabinina’s story is among several that Italian photographer Giuseppe Nucci documents in -196: The Pioneers of Resurrection. His ethereal, atmospheric images respectfully capture the quest for immortality in Russia, home to a visionary gaggle of cosmists, cryonicists, and transhumanists who believe in a deathless future. They preach resurrection, wear high-tech cyber-suits, and deep-freeze the corpses of loved ones they hope to meet again.

Continue reading “The Mystics Seeking Eternal Life Through Liquid Nitrogen” »

The smallest Imperial Walker to ever attack the rebel alliance.

When it comes to matching simplicity with staggering creative potential, DNA may hold the prize. Built from an alphabet of just four nucleic acids, DNA provides the floorplan from which all earthly life is constructed.

But DNA’s remarkable versatility doesn’t end there. Researchers have managed to coax segments of DNA into performing a host of useful tricks. DNA sequences can form logical circuits for nanoelectronic applications. They have been used to perform sophisticated mathematical computations, like finding the optimal path between multiple cities. And DNA is the basis for a new breed of tiny robots and nanomachines. Measuring thousands of times smaller than a bacterium, such devices can carry out a multitude of tasks.

Continue reading “Built for speed: DNA nanomachines take a (rapid) step forward” »

MINNEAPOLIS/ST.PAUL (03/01/17) — A research team, led by the University of Minnesota, has discovered a groundbreaking process to successfully rewarm large-scale animal heart valves and blood vessels preserved at very low temperatures. The discovery is a major step forward in saving millions of human lives by increasing the availability of organs and tissues for transplantation through the establishment of tissue and organ banks.

The research was published today in Science Translational Medicine, a peer-reviewed research journal published by the American Association for the Advancement of Sciences (AAAS). The University of Minnesota holds two patents related to this discovery.

“This is the first time that anyone has been able to scale up to a larger biological system and demonstrate successful, fast, and uniform warming hundreds of degrees Celsius per minute of preserved tissue without damaging the tissue,” said University of Minnesota mechanical engineering and biomedical engineering professor John Bischof, the senior author of the study.

Continue reading “Groundbreaking technology successfully rewarms large-scale tissues preserved at very low temperatures” »

Let’s imagine it’s mid flu season, and a stranger at the grocery store sneezes on you.

Wouldn’t it be great to know if you’re destined for weeks of sweats and chills; or if, by the grace of your immune system, you might just make it out unscathed?

Purvesh Khatri, PhD, associate professor of medicine at Stanford, has discovered a biomarker in the blood may be able to do just that. It’s a gene that codes for a protein that lives on the surface of a type of immune cell known as a “natural killer” cell. The findings of the study, published in Genome Medicine, have been in the works for about four years, and it’s the first time (to Khatri’s knowledge) that a biomarker for flu susceptibility has been identified.

Continue reading “Will you get sick next flu season? It may depend on how many natural killer cells you have” »

Scientists used stem cells to grow a miniature model of a Neanderthal’s brain for the first time. The tiny blob of neurons reveals what makes us different.