Lifeboat Foundation

Researchers at the Buck Institute have extensively profiled the various inflammatory signals given off by senescent human cells and have generated a curated database available for use in the field.

Senescent cells, which stop dividing under stress, are long- recognized drivers of multiple diseases of aging. Mouse studies have shown that targeted removal of these cells and the inflammatory factors they secrete, known as the senescence-associated secretory phenotype (SASP), has beneficial results on multiple organ systems and functions. Success in the laboratory has given rise to companies and research projects aimed at developing either senolytics, drugs that clear senescent cells, or senomorphics, drugs that suppress the SASP. But drug development and clinical utilization require simple, reliable biomarkers to assess the abundance of senescent cells in human tissues. Publishing in PLOS Biology, researchers at the Buck Institute have extensively profiled the SASP of human cells and have generated a curated database available for use in the field.

“The stage is now set for the development of clinically-relevant biomarkers of aging,” said Judith Campisi, Ph.D., Buck professor and one of the senior authors on the paper. “This will speed efforts to get safe and effective drugs into the clinic and, in the long term, could enable physicians to give patients a clear read-out of how well, or poorly, their various tissues and organs are aging.”

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A startup focused on “invisible computing” Thursday unveiled a smart contact lens which delivers an augmented reality display in a user’s field of vision.

The Mojo Vision contact lens offers a display with information and notifications, and allows the user to interact by focusing on certain points.

The rigid contact lens, which the company has been developing in stealth mode for some 10 years, may also be used to help people with visual impairments by using enhanced image overlays, and has obtained US approval for testing it as a medical device.

A dumbbell-shaped nanoparticle powered just by the force and torque of light has become the world’s fastest-spinning object.

Scientists at Purdue University created the object, which revolves at 300 billion revolutions per minute. Or, put another way, half a million times faster than a dentist’s drill.

In addition, the silica nanoparticle can serve as the world’s most sensitive torque detector, which researchers hope will be used to measure the friction created by quantum effects.

463 million people have been diagnosed with diabetes worldwide and up to 95% of this number have Type 2.

Lannett Company, Inc. (NYSE: LCI) today announced that the U.S. Food and Drug Administration (FDA) has approved the New Drug Application (NDA), submitted under the 505(b) regulatory pathway, for Cocaine Hydrochloride (HCl) Nasal Solution 4% (40 mg/mL), the company’s branded local anesthetic product.

PHILADELPHIA, Jan. 13, 2020 /PRNewswire/ — Lannett Company, Inc. (NYSE: LCI) today announced that the U.S. Food and Drug Administration (FDA) has approved the New Drug Application (NDA), submitted under the 505(b) regulatory pathway, for Cocaine Hydrochloride (HCl) Nasal Solution 4% (40 mg/mL), the company’s branded local anesthetic product.

“The FDA’s approval of our Cocaine HCl product, the first NDA approval to include full clinical trials in the company’s history, marks a major milestone in Lannett’s 70+ years of operations,” said Tim Crew, chief executive officer of Lannett. “We believe the product has the potential to be an excellent option for the labeled indication. We expect to launch the product shortly, under the brand name NUMBRINO^®.”

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OmniVision OV6948 makes it into Guinness Book of Records and will save lives in the hands of surgeons.

Writing in Nature, researchers describe the first-time observation of ‘self-organized criticality’ in a controlled laboratory experiment. Complex systems exist in mathematics and physics, but also occur in nature and society. The concept of self-organized criticality claims that without external input, complex systems in non-equilibrium tend to develop into a critical state far away from a stable equilibrium. That way, they reinforce their own non-equilibrium.

Systems that are at first glance quite different, like the dissemination of information in social networks or the spread of fire or disease, may have similar characteristics. One example is an avalanche-like behaviour that reinforces itself instead of coming to a standstill. However, these complex systems are very difficult to study under controlled lab conditions.

For the first time, researchers from the European Centre for Quantum Sciences (CESQ) in Strasbourg, in collaboration with researchers from the universities of Cologne and Heidelberg and the California Institute of Technology, have succeeded in observing the most important features of self-organized criticality in a controlled experiment—including universal avalanche behavior.

With 360 video, IEEE Spectrum takes you behind the scenes with one of the world’s first drone-delivery companies. Zipline, based in California, is using drones to deliver blood to hospitals throughout Rwanda. At an operations center in Muhanga, you’ll watch as Zipline technicians assemble the modular drones, fill their cargo holds, and launch them via catapult. You’ll see a package float down from the sky above a rural hospital, and you’ll get a closeup look at Zipline’s ingenious method for capturing returning drones.

You can follow the action in a 360-degree video in three ways: 1) Watch on your computer, using your mouse to click and drag on the video; 2) watch on your phone, moving the phone around to change your view; or 3) watch on a VR headset for the full immersive experience.

Continue reading “360 Video: Go on a Mission With Zipline’s Delivery Drones” »