Lifeboat Foundation

Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small molecules to include nucleic acids, peptides, proteins and antibodies, drug delivery technologies were adapted to address the challenges that emerged. In this Review Article, we discuss seminal approaches that led to the development of successful therapeutic products involving small molecules and macromolecules, identify three drug delivery paradigms that form the basis of contemporary drug delivery and discuss how they have aided the initial clinical successes of each class of therapeutic. We also outline how the paradigms will contribute to the delivery of live-cell therapies.

This Review Article discusses how delivery challenges associated with small molecules, nucleic acids, peptides, proteins and cells led to the development of commercial products and are now informing the delivery of live-cell therapeutics.

My story centers on the concept of a genetically modified virus (named) which infects the brain and gives people enhanced empathy. The narrative takes place in a fictional middle eastern city called Fakhoury and explores bioethical themes. Love acts as a central motif which ties the story together. Note that this piece will be available online for a limited time, after which you will need to pay for the magazine. I encourage you to check out my story!

Read Philosophy Ethics Short Stories with your friends, family, book club, and students. Each story comes with suggested discussion questions.

Bloomberg counted up the shots administered in 183 countries and 59 U.S. states and territories.

A new study indicates that some young people may experience changes to their “fight or flight” response after having recovered from COVID-19.

After comparing the gut microbiomes of 160 centenarians with those of the elderly and young, scientists found centenarian microbiomes had a special mix.

Obstructive sleep apnea is widely “underrecognized and underdiagnosed.” But individuals with moderate to severe sleep apnea have a notable elevated risk of mortality from cancer and stroke compared to individuals without. People with obstructive sleep apnea and parasomnia have higher risks of breast cancer. The same study finds that parasomnia also increases the risk of oral cancer.

Update 8/23/2021: This post has been updated since we originally published it in October 2020. I evaluated additional top sleep trackers and apps for 2,022 added Biostrap, updated the post to reflect most recent pricing, and added additional commentary on my reviews. The post has been cleaned up and links were made current.

I didn’t used to have a harmonious relationship with sleep. In fact, sleep used to be a source of anxiety for me. I have parasomnia, an amalgam of disorders that, occasionally, give me hypnopompic hallucinations Severe hallucinations when waking up from a deep sleep. 0 night terrors Nightmares that lead the dreamer to wake up screaming and thrashing without recollection of the dream itself 0 and, most dangerously, somnambulism The fancy word for ‘sleepwalking.’ 0 which has led me to drive while sleeping and scare the living piss out of my poor husband after we watched Paranormal Activity together (it didn’t help that I was mutely standing over him at 4:15 AM with my eyes wide open).

Continue reading “9 Best Sleep Trackers and Apps for Longevity in 2022” »

Dravet syndrome (DS) is a developmental and epileptic encephalopathy with an increased incidence of sudden death. Evidence of interictal breathing deficits in DS suggests that alterations in subcortical projections to brainstem nuclei may exist, which might be driving comorbidities in DS.

Summary: Researchers have identified a circuit within the brain that may be responsible for respiratory dysfunction and sudden death associated with Dravet syndrome.

Source: Vanderbilt University

Continue reading “Sudden Death From Deep in the Brain?” »

Craig Montell is a professor at the University of California, Santa Barbara, who helped lead the research. He said in a statement that by removing the two eye receptors, the team was able to “eliminate CO2-induced target recognition without causing blindness.”

Female Aedes aegypti search out blood meals in humans to develop eggs. They use several different senses to find those meals. One of the main identifying tools is the smell of carbon dioxide (CO₂). When a human breathes out CO₂, the mosquitoes become more active and begin looking for targets to bite.

The research team said this search generally begins with the mosquito flying toward the direction of the released CO₂. When seeking out targets, the insects search for dark objects. Once the mosquitoes are within close range, they can also sense heat from skin and additional skin smells to help guide them to a human.

Continue reading “Gene Editing Used to Block Mosquitos’ Ability to Identify Targets” »

#Biology #biochemistry #Biochemist #biotech #bio

This video explains introduction to biochemistry.

Continue reading “Introduction to Biochemistry” »