Faster protein engineering could mean faster responses to emerging infections and cheaper drugs.
The dual-use problem
Researchers have raised concerns that these same AI tools could be misused, a challenge known as the dual-use problem: Technologies developed for beneficial purposes can also be repurposed to cause harm.
This study shows that a TRUE-MOGAD score of 2 or more accurately predicts MOGAD in patients with MOG-IgG titers of 1:20 or higher using the described assay. Read more.
Myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-IgG) are a biomarker of MOG antibody-associated disease (MOGAD). However, false positives remain common. We aimed to develop a scoring tool to guide interpretation.
Using gene-editing technology, scientists and start-ups are aiming to provide electricity-free illumination.
MIT’s Department of Mechanical Engineering (MechE) offers a world-class education that combines thorough analysis with hands-on discovery. One of the original six courses offered when MIT was founded, MechE faculty and students conduct research that pushes boundaries and provides creative solutions for the world’s problems.
The exploit only affected Build 42 branches of Project Zomboid (the game’s current ‘unstable’ testing release), so if you’re on Build 41, you were “not vulnerable to this specific issue,” the dev said. While The Indie Stone hasn’t determined what the malicious files were actually doing, “we strongly recommend that anyone who downloaded them take appropriate security measures to ensure their system is safe. Simply uninstalling the mods is not sufficient.”
If you use mods in Project Zomboid, check them against the list below to determine if you’ve downloaded and run any of these mods, which all look to be sound or music-related.
Organoids are miniature, simplified versions of an organ. Over the past two decades, scientists have developed them for the gut, lung, liver, mammary gland, brain, and more. Now, researchers at Yale School of Medicine (YSM) have organoid-ized the pineal gland, a small structure in the brain that regulates sleep patterns through its production of the hormone melatonin.
In a study published in Cell Stem Cell, the researchers demonstrate how pineal gland organoids can be used to study sleep dysfunction in conditions like Angelman syndrome, autism, and depression.
“In a number of neuropsychiatric conditions, severe sleep problems are a major symptom,” says In-Hyun Park, Ph.D., associate professor of genetics at YSM and senior author of the study. “With pineal gland organoids, we may be able to uncover the causes of those sleep disturbances and possibly identify treatments.”
A routine blood test taken by millions in the U.S. each year to measure “bad” cholesterol is not the best measure to guide treatment and prevent heart attacks and strokes, suggests a new Northwestern Medicine study published in JAMA. The study found that another blood test called apolipoprotein B (apoB) outperformed LDL and non-HDL cholesterol in guiding cholesterol-lowering therapy, such as taking statins and other medications.
“We found that apoB testing to intensify cholesterol-lowering medication would prevent more heart attacks and strokes than current practice, and that these health benefits were achieved at a cost that represents good value for U.S. health care payers,” said study lead author Ciaran Kohli-Lynch, assistant professor of preventive medicine in the division of epidemiology at Northwestern University Feinberg School of Medicine.
According to Kohli-Lynch, this is the first comprehensive study to show that using apoB testing to guide cholesterol-lowering treatment is cost-effective.