Lifeboat Foundation

Today, we are going to take a look at the topic of NAD+, its precursor, nicotinamide mononucleotide, and the debate surrounding the ability of these molecules to pass through the cell membrane.

NAD+ is critical for cellular function

Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor, but it is also a critical signaling molecule that regulates cell function and survival in response to environmental changes such as nutrient intake and cellular damage. Age-related changes to the level of NAD+ in the cell impacts mitochondrial function, nutrient sensing and metabolism, redox reactions, circadian rhythm, immune and inflammatory responses, DNA repair, cell division, protein-to-protein signaling, chromatin, and epigenetics.

Why the spike? For years, doctors doled out antibiotics willy-nilly. Even today, up to half of all prescribed antibiotics are unnecessary or used ineffectively.

Whenever antibiotics are used, some mutant bacteria survive. But the more an antibiotic is used, the more rapidly bacteria become resistant, reducing the effectiveness of the drug.

New treatments for superbugs are needed, but there have been no major novel antibiotic developments since the 1960s. That’s largely because pharmaceutical companies are abandoning antibiotic research. It’s time-consuming and expensive to bring a new drug to market — it takes about ten years and $2.9 billion, on average. So companies develop drugs that will make as much money as possible. Since drugs for chronic diseases make people life-long subscribers, and antibiotics are “one and done,” developers opt to make the former. Moreover, growing antibiotic resistance reduces the effective lifespan of new drugs, further limiting profits.

Continue reading “Antibiotic-Resistant Superbugs Are Getting Deadlier” »

Chances are you make it through most days without sparing a thought for Antarctica. At just over 5.4 million square miles, it’s a massive chunk of land that is nearly twice the size of Australia and dwarfs the continental United States. It’s also covered in ice, which makes it a lot less appealing as a potential vacation destination.

Still, it’s of great interest to scientists and researchers, and a new mapping effort has yielded the most stunning, high-resolution glimpse of the continent ever.

Scientists have developed a photoelectrode that can harvest 85 percent of visible light in a 30 nanometers-thin semiconductor layer between gold layers, converting light energy 11 times more efficiently than previous methods.

In the pursuit of realizing a sustainable society, there is an ever-increasing demand to develop revolutionary solar cells or artificial photosynthesis systems that utilize visible light energy from the sun while using as few materials as possible.

The research team, led by Professor Hiroaki Misawa of the Research Institute for Electronic Science at Hokkaido University, has been aiming to develop a photoelectrode that can harvest visible light across a wide spectral range by using gold nanoparticles loaded on a semiconductor. But merely applying a layer of gold nanoparticles did not lead to a sufficient amount of light absorption, because they took in light with only a narrow spectral range.

Continue reading “Photoelectrode that can harvest 85 percent of visible light” »

A 2011 invention made by Aalto University’s researchers has proceeded from concept to reality. Just a few years ago the researchers obtained the record efficiency of 22% in the lab for nanostructured solar cells using atomic layer deposition, and now with the help of industrial partners and joint European collaboration, the first prototype modules have been manufactured on an industrial production line.

“Our timing could not have been better” prof. Hele Savin, who led the research, was pleased to tell. Indeed, 2018 is commonly called the “Year of Black Silicon” due to its rapid expansion in the photovoltaic (PV) industry. It has enabled the use of diamond-wire sawing in multicrystalline silicon, which reduces costs and environmental impact. However, there is still plenty of room for improvement as the current black silicon used in industry consists of shallow nanostructures that leads to sub-optimal optical properties and requires a separate antireflection coating.

Aalto’s approach consists of using deep needle-like nanostructures to make an optically perfect surface that eliminates the need for the antireflection coatings. Their industrial production, however, was not an easy task. “We were worried that such a fragile structure would not survive the multi-step mass production, because of rough handling by robots or module lamination.”

Continue reading “First truly black solar modules roll off industrial production line” »

Our mission is to make air travel personal, on demand and carbon free.

New observations from NASA’s Chandra X-ray Observatory reveal a very bright source of X-rays that is likely powered by either a ring of stellar-mass black holes or neutron stars located 300 million light-years from Earth.

In some domains the two knowledge systems are complementary, but in others they might be headed for conflict.

• By Abraham Loeb on September 10, 2018

Interfacing quantum information between discrete and continuous would allow exploiting the best of both worlds, but it has been shown only for single-rail encoding. Here, the authors extend this to the more practical dual-rail encoding, realizing teleportation between a polarization qubit and a CV qubit.