Lifeboat Foundation

LA JOLLA—(February 18, 2019) Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer’s disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy to help decelerate the aging process.

The findings, published on February 18, 2019 in the journal Nature Medicine, highlight a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome, a rare genetic disorder that also afflicts humans. This treatment provides important insight into the molecular pathways involved in accelerated aging, as well as how to reduce toxic proteins via gene therapy.

“Aging is a complex process in which cells start to lose their functionality, so it is critical for us to find effective ways to study the molecular drivers of aging,” says Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory and senior author of the paper. “Progeria is an ideal aging model because it allows us to devise an intervention, refine it and test it again quickly.”

Continue reading “A new CRISPR/Cas9 therapy can suppress aging” »

There are 1.4 billion insects for each one of us. Though you often need a microscope to see them, insects are “the lever pullers of the world,” says David MacNeal, author of Bugged. They do everything from feeding us to cleaning up waste to generating $57 billion for the U.S. economy alone.

Today, many species are faced with extinction. When National Geographic caught up with MacNeal in Los Angeles, he explained why this would be catastrophic for life on Earth and why a genetically engineered bee could save hives—and our food supply—worldwide.

This is Part 1 of a 5-part series by USTP’s Foreign Ambassador in Nigeria, Chogwu Abdul, as he explores the thought-provoking intricacies of James Hughes’ “Problems of Transhumanism.”

Become a member of the U.S. Transhumanist Party / Transhuman Party for free, no matter where you reside: https://transhumanist-party.org/membership/

Ojochogwu Abdul

Introduction

Continue reading “James Hughes’ Problems of Transhumanism: A Review (Intro + Part 1)” »

It should be possible to automatically identify dubious news sources—but we’ll need a lot more data.

In field trials, colonies fed mycelium extract from amadou and reishi fungi showed a 79-fold reduction in deformed wing virus and a 45,000-fold reduction in Lake Sinai virus compared to control colonies.

Though it’s in the early stages of development, the researchers see great potential in this research.

“Our greatest hope is that these extracts have such an impact on viruses that they may help varroa mites become an annoyance for bees, rather than causing huge devastation,” said Steve Sheppard, a WSU entomology professor and one of the paper’s authors. “We’re excited to see where this research leads us. Time is running out for bee populations and the safety and security of the world’s food supply hinges on our ability to find means to improve pollinator health.”

A new map of the night sky using the Low Frequency Array @LOFAR telescope charts hundreds of thousands of previously unknown galaxies.

The international team behind the unprecedented space survey said their discovery literally shed new light on some of the Universe’s deepest secrets, including the physics of black holes and how clusters of galaxies evolve.

In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their original healthy size, as is typically seen in aged and senescent cells.

They demonstrate that in enlarged yeast and human cells, RNA and protein biosynthesis does not scale in proportion to the additional cell size, which then leads to a dilution of the cytoplasm. This phenomenon is also present in senescent cells, which display similar traits to those of large cells.

The research team concludes that the maintenance of a cell type-specific DNA-to-cytoplasm ratio is essential for the majority of cellular functions, and when cellular growth changes this ratio, it encourages cells to become senescent.

Continue reading “Excessive Cell Size Contributes to Senescence” »

The known Universe just got a lot bigger.

A new map of the night sky published Tuesday charts hundreds of thousands of previously unknown galaxies discovered using a telescope that can detect light sources optical instruments cannot see. Current latest trending Philippine headlines on science, technology breakthroughs, hardware devices, geeks, gaming, web/desktop applications, mobile apps, social media buzz and gadget reviews.

As commercial space exploration accelerates, companies are perfecting the space suits of tomorrow. What do our space suit designs say about the past and future of the American dream?

Author: Alissa GreenbergPublish date: