Lifeboat Foundation

What is reality and how do we know? For many the answer is simple: What you see — hear, feel, touch, and taste — is what you get.

Your skin feels warm on a summer day because the sun exists. That apple you just tasted sweet and that left juices on your fingers, it must have existed. Our senses tell us that reality is there, and we use reason to fill in the blanks — that is, we know the sun doesn’t cease to exist at night even if we can’t see it.

But cognitive psychologist Donald Hoffman says we’re misunderstanding our relationship with objective reality. In fact, he argues that evolution has cloaked us in a perceptional virtual reality. For our own good.

If you want a vision of the future, imagine a thousand bots screaming from a human face – forever (apologies to George Orwell). As U.S. policymakers remain indecisive over how to prevent a repeat of the 2016 election interference, the threat is looming ever more ominous on the horizon. The public has unfortunately settled on the term “bots” to describe the social media manipulation activities of foreign actors, invoking an image of neat rows of metal automatons hunched over keyboards, when in reality live humans are methodically at work. While the 2016 election mythologized the power of these influence-actors, such work is slow, costly, and labor-intensive. Humans must manually create and manage accounts, hand-write posts and comments, and spend countless hours reading content online to signal-boost particular narratives. However, recent advances in artificial intelligence (AI) may soon enable the automation of much of this work, massively amplifying the disruptive potential of online influence operations.

This emerging threat draws its power from vulnerabilities in our society: an unaware public, an underprepared legal system, and social media companies not sufficiently concerned with their exploitability by malign actors. Addressing these vulnerabilities requires immediate attention from lawmakers to inform the public, address legal blind spots, and hold social media companies to account.

Samsung Galaxy Note 10 and Galaxy Note 10 Plus hands on.
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This is my Samsung Galaxy Note hands on video. The Note 10 (Plus) represents Samsung’s top tier smartphone offering packing a 6.8-inch AMOLED display and up to 12GB of RAM.

Continue reading “Samsung Galaxy Note 10 Hands On” »

Fighting Antibiotic Resistance By Repurposing Old Drugs : Shots — Health News Scientists discovered that a medication used to treat parasites in horses can fight deadly staph infections. It’s a promising new approach to solving the problem of antibiotic resistance.

The ability to modify multiple genetic elements simultaneously would help to elucidate and control the gene interactions and networks underlying complex cellular functions. However, current genome engineering technologies are limited in both the number and the type of perturbations that can be performed simultaneously. Here, we demonstrate that both Cas12a and a clustered regularly interspaced short palindromic repeat (CRISPR) array can be encoded in a single transcript by adding a stabilizer tertiary RNA structure. By leveraging this system, we illustrate constitutive, conditional, inducible, orthogonal and multiplexed genome engineering of endogenous targets using up to 25 individual CRISPR RNAs delivered on a single plasmid. Our method provides a powerful platform to investigate and orchestrate the sophisticated genetic programs underlying complex cell behaviors.

The sugar-rich Western diet is fueling a superbug which has evolved to thrive in hospitals, scientists have warned.

The gut-infecting bacterium Clostridium difficile (C.diff) is evolving into two separate species, with one group increasingly adapting to live in the guts of people with poor diets, while growing ever better at avoiding the harsh disinfectants used to clean wards.

More than 13,000 NHS patients each year are infected with C.diff, which can cause debilitating diarrhoea and leave sick people dangerously dehydrated.

Cyber-espionage group Cloud Atlas has added polymorphic malware to its arsenal to avoid having its operations detected and monitored with the help of previously collected indicators of compromise (IOCs).

The hacking group also known as Inception [1, 2] was initially identified in 2014 by Kaspersky’s Global Research and Analysis Team researchers, and it has a history of targeting government agencies and entities from a wide range of industries via spear-phishing campaigns.

While the malware and Tactics, Techniques, and Procedures (TTP) Cloud Atlas uses during its operations has remained unchanged since at least 2018, the APT group has now added new polymorphic HTML Application malware dropper in the form of a malicious HTA and a backdoor dubbed VBShower.

A SPACESHIP which is so fast it could travel 3.6 million miles per day has been successfully tested in Earth orbit.

Today the U.S. Food and Drug Administration announced a comprehensive policy framework for the development and oversight of regenerative medicine products, including novel cellular therapies.

The framework — outlined in a suite of four guidance documents — builds upon the FDA’s existing risk-based regulatory approach to more clearly describe what products are regulated as drugs, devices, and/or biological products. Further, two of the guidance documents propose an efficient, science-based process for helping to ensure the safety and effectiveness of these therapies, while supporting development in this area. The suite of guidance documents also defines a risk-based framework for how the FDA intends to focus its enforcement actions against those products that raise potential significant safety concerns. This modern framework is intended to balance the agency’s commitment to safety with mechanisms to drive further advances in regenerative medicine so innovators can bring new, effective therapies to patients as quickly and safely as possible. The policy also delivers on important provisions of the 21^st Century Cures Act.

We’re at the beginning of a paradigm change in medicine with the promise of being able to facilitate regeneration of parts of the human body, where cells and tissues can be engineered to grow healthy, functional organs to replace diseased ones; new genes can be introduced into the body to combat disease; and adult stem cells can generate replacements for cells that are lost to injury or disease. This is no longer the stuff of science fiction. This is the practical promise of modern applications of regenerative medicine.