Lifeboat Foundation

Circa 2018 we need crispr pills for this.

The steady march of aging might not have to be so steady, according to a growing body of research. Now a team from the University at Buffalo has isolated a single gene that controls senescence, the process that stops cells from dividing and contributes to aging symptoms. Ramping it up, they found how easily the effect can spread among neighboring cells. That makes the gene a crucial target for future work into anti-aging and cancer therapies.

Living cells have a natural limit to the amount of times they can divide, before they stop and become what are known as senescent cells. The problem is, over time these senescent cells build up in the body, eventually contributing to the physical symptoms we associate with aging, such as increased risk of diabetes, heart disease, arthritis and cataracts. On the other hand though, completely halting senescence can lead to cancer, as the cells continue to divide unchecked.

Continue reading “Scientists single out gene that triggers aging symptoms” »

Circa 2017 o.o

Lightning is nuts. It’s a supercharged bolt of electricity extending from the sky to the ground that can kill people. But it can also produce nuclear reactions, according to new research.

Scientists have long known that thunderstorms can produce high-energy radiation, like this one from December, 2015 that blasted a Japanese beach town with some gamma radiation. But now, another team of researchers in Japan are reporting conclusive evidence of these gamma rays setting off atom-altering reactions like those in a nuclear reactor.

This invention helps people put on their socks without bending down.

This bionic fingertip can restore the sense of touch for amputees.

No one has seen an equinox this early since the 19th century: March 19 everywhere in the USA. And you’d better get used to it.

Let’s say it was possible to buy your health by the day. How much would you be willing to pay for each year of perfect health? What if you could buy years of health for your loved ones, too? At what price point would you draw the line?

This sort of difficult calculus, on a much larger and chronologically longer scale, underpins many decisions we make in medicine — not just decisions that we make as patients, but also the decisions that are made for us by employers, health insurance funders and policymakers. We don’t have the resources to pursue every possible treatment, to research every possible breakthrough, so how do we allocate the resources available? It turns out that there is an entire field of healthcare economics devoted to understanding the costs and benefits of conventional medicine, and to navigating the trade-offs between more expense and better healthcare.

Continue reading “Econogenomics: The Economics of Genomic Testing for Health” »

Researchers from AgeX Therapeutics and other organizations have proved the feasibility of reprogramming banked cells derived from a supercentenarian. Their discovery portends exciting new possibilities for aging research.

What is cellular reprogramming?

Cellular reprogramming is the process of reverting mature, specialized cells into induced pluripotent stem cells (iPSCs), which can develop into any cell type found in the human body. Cellular reprogramming technology was pioneered in 2006 by Drs. Takahashi and Yamanaka, who achieved this impressive result by overexpressing just four genes, Oct4, Sox2, Klf4, and c-Myc (OSKM), which became collectively known as the Yamanaka factors. For this breakthrough, Yamanaka was awarded the Nobel Prize in 2012. Fun fact: Yamanaka called these cells iPSCs – with a small “i” – as a nod to the iPod and similarly named devices.

What do you think?

In science fiction stories, research can accidentally create superintelligent animal species. As the ability to alter animals’ brains grows, some say we should be wary of fiction becoming reality.

University of Exeter team make senescent cells look younger and begin to divide while exhibiting longer telomeres to reduce cellular aging.