Lifeboat Foundation

In the past few decades, researchers discovered that the rate at which we age is strongly influenced by biochemical processes that, at least in animal models, can be controlled in the laboratory. Telomere shortening is one of these processes; another is the ability of cells to detect nutrients mediated by the mTOR protein. Researchers have been able to prolong life in many species by modifying either one of them. But what if they manipulate both?

A team from the Spanish National Cancer Research Centre (CNIO) has studied it for the first time, with unexpected results. Blocking nutrient sensing by treatment with rapamycin, an mTOR inhibitor, delays the aging of healthy mice, but curiously, it worsens diseases and premature aging that occur in mice with short telomeres. This finding has important implications for the treatment of diseases associated with short telomeres, but also for age-related diseases that are also associated with short telomeres. The study, done by the Telomeres and Telomerase Group headed by Maria Blasco at the CNIO, is published in Nature Communications with Iole Ferrara-Romeo as the first author.

Telomeres, regions of repetitive nucleotide sequences at the end of chromosomes, preserve the genetic information of the cells. They shorten with age until they can no longer fulfill their function: The cells stop dividing and the tissues age since they are no longer able to regenerate.

An unprecedented human study aims to induce statistically significant and meaningful biological age reversal using multi-model interventions that include metformin, dasatinib, rapamycin, and NAD+ restoration therapy.

By William Faloon.

We’ve been expecting aliens from Mars for decades now, but what if life was vanquished on the red planet before evolution ever got the chance to take hold?

A pair of researchers recently published an analysis of 3.5 billion-years-old soil samples from Mars containing chemical compounds called “thiophenes” that could, potentially, be organic. If they are, it would be highly likely that bacteria once lived on the planet.

Terrestrial thiophenes are considered tell-tale signs of life by Earthbound biologists. The presence of these possibly-organic compounds in Martian soil represents the strongest evidence yet that life may have once existed anywhere other than Earth.

Amid a coronavirus outbreak in the United States, the US Centers for Disease Control and Prevention is encouraging older people and people with severe chronic medical conditions to “stay at home as much as possible.”

This advice is on a CDC website that was posted Thursday, according to a CDC spokeswoman.

Early data suggests older people are twice as likely to have serious illness from the novel coronavirus, according to the CDC.

Scientists believe they’ve made a concrete example of an unusual, theoretical form of ferromagnetism first described by a researcher more than 50 years ago.

Nagaoka ferromagnetism, named for the scientist who discovered it, Yosuke Nagaoka, is a special case of the same magnetic forces that make regular, refrigerator-type magnets work—ferro meaning iron, plus a few other metals that are naturally receptive to magnetism. Identifying it in real life—in this case using a quantum system of electrons—can help scientists understand how spontaneous ferromagnetism works.

Dr. Jill Bolte Taylor describes a ringside seat to her own stroke and how you can use her experience to sustain hard knocks in the workplace and in life.

To date, teaching a robot to perform a task has usually involved either direct coding, trial-and-error tests or handholding the machine. Soon, though, you might just have to perform that task like you would any other day. MIT scientists have developed a system, Planning with Uncertain Specifications (PUnS), that helps bots learn complicated tasks when they’d otherwise stumble, such as setting the dinner table. Instead of the usual method where the robot receives rewards for performing the right actions, PUnS has the bot hold “beliefs” over a variety of specifications and use a language (linear temporal logic) that lets it reason about what it has to do right now and in the future.

Researchers say brain pathways begin to erode in late 40s, but can be repaired through dietary changes.

Avigan was developed as a flu medicine and also has been used for Ebola virus disease (EVD) treatment. EVD, which causes fatal hemorrhagic fever, resulted in more than 11,300 deaths in the West Africa region between 2014 and 2016. There is currently another outbreak in the Democratic Republic of Congo that has seen more than 2,000 fatalities to date.

HONG KONG – Fujifilm Holdings Corp. stock (TYO:4901) jumped 8.8% to ¥5,890 (US$53.48) on Feb. 25, as Japan considers using Avigan (favipiravir), an anti-influenza medication developed by the company’s Toyama Chemical Co. Ltd., to treat COVID-19. The share price ended the day at ¥5,567, for a gain of 2.83%.

The medication attracted market attention when Minister of Health, Labor and Welfare Katsunobu Kato said on Feb. 22 that the country is planning to test Avigan against COVID-19. “We hear from foreign countries that some drugs among those that have been used against influenza may be useful,” Kato said.

Continue reading “Fujifilm stock rises as Japan considers Avigan for COVID-19 treatment” »