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Study after study has shown that statins can prevent heart attacks, strokes and death in middle-aged adults. But in 28 major clinical trials of statins, only 2 percent of participants have been 75 years or older. This means that even though older adults are at greater risk of heart disease and death, there is scant data on whether statins should be prescribed for them.

A new study led by investigators from Brigham and Women’s Hospital and VA Boston Healthcare System leverages national data from the U.S. Veterans Health Administration Services and Centers for Medicare & Medicaid Services to shed new light on the role statins may play for older adults who have not yet experienced a , stroke or other cardiovascular event. In their retrospective analysis, the researchers found that the risk of dying from any cause was lower by 25 percent among veterans who were using statins compared to those who were not treated with statins. The risk of dying from a cardiovascular event, such as a heart attack or stroke, was lower by 20 percent. The team’s results are published in JAMA.

“Based on these data, age is not a reason to not prescribe statins,” said lead and corresponding author Ariela Orkaby, MD, MPH, a physician scientist at VA Boston Health Care System and in the Division of Aging at the Brigham. “Statins are commonly studied and prescribed for middle-aged adults but understudied in people over age 75. One of the most remarkable things about our results is that we found the benefit of statins held true regardless of whether a person was older or younger or had a condition such as dementia.”

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There is no really useful treatments for Pancreatic Cancer, also it’s really deadly. So this sounds like awesome science news! “Cancer cells in the pancreas seem to thrive off this hyperactive cholesterol synthesis. The team thinks this is probably because they are taking advantage of other molecules generated by the same pathway. They’re able to keep the pathway running and maintain their supply thanks to an enzyme called sterol O-acyltransferase 1 (SOAT1), which converts free cholesterol to its stored form and which pancreatic cancer cells have in abundance.” “When the researchers eliminated the SOAT1 enzyme through genetic manipulation, preventing cells from converting and storing their cholesterol, cancer cells stopped proliferating. In animal experiments, eliminating the enzyme stalled tumor growth.”

Scientists at Cold Spring Harbor Laboratory (CSHL) have found that they can stop the growth of pancreatic cancer cells by interfering with the way the cells store cholesterol. Their findings in mice and lab-grown pancreas models point toward a new strategy for treating the deadly disease.

The study, reported in the Journal of Experimental Medicine, was led by CSHL Professor David Tuveson’s team wanted to know why pancreatic , like many , manufacture abundant amounts of cholesterol. Cholesterol is an essential component of cell membranes, but the research team determined that pancreatic cancer cells make far more of it than they need to support their own growth. “This is unusual, because the cholesterol pathway is one of the most regulated pathways in metabolism,” says Tobiloba Oni, a graduate student in Tuveson’s lab.

Most cells make only as much cholesterol as they need, quickly shutting down the synthesis pathway once they have enough, Oni explains. But he and his colleagues, including Giulia Biffi, a former postdoctoral fellow in Tuveson’s lab, found that cancer cells convert most of the cholesterol they make into a form that can be stored within the cell. Free cholesterol never accumulates, and the synthesis pathway keeps churning out more.

Continue reading “Blocking cholesterol storage could stop growth of pancreatic tumors” | >

The European Union has confirmed that American citizens will not be allowed to enter its borders as the bloc begins to ease travel restrictions imposed earlier this year in response to the pandemic. Travelers from America, as well as Brazil and Russia, have been barred from entry because of their countries’ inability to contain the spread of the coronavirus.

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Researchers at CRANN and Trinity’s School of Physics have created an innovative new device that will emit single particles of light, or photons, from quantum dots that are the key to practical quantum computers, quantum communications, and other quantum devices.

The team has made a significant improvement on previous designs in photonic systems via their device, which allows for controllable, directional emission of single photons and which produces entangled states of pairs of .

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In fact, in a recent paper in Royal Society Open Science, researchers showed that AI tasked with maximizing returns is actually disproportionately likely to pick an unethical strategy in fairly general conditions. Fortunately, they also showed it’s possible to predict the circumstances in which this is likely to happen, which could guide efforts to modify AI to avoid it.

The fact that AI is likely to pick unethical strategies seems intuitive. There are plenty of unethical business practices that can reap huge rewards if you get away with them, not least because few of your competitors dare use them. There’s a reason companies often bend or even break the rules despite the reputational and regulatory backlash they could face.

Those potential repercussions should be of considerable concern to companies deploying AI solutions, though. While efforts to build ethical principles into AI are already underway, they are nascent and in many contexts there are a vast number of potential strategies to choose from. Often these systems make decisions with little or no human input and it can be hard to predict the circumstances under which they are likely to choose an unethical approach.

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After more than a year in a clay-rich region, Curiosity is making a mile-long journey around some deep sand so that it can explore higher up Mount Sharp.

NASA’s Curiosity Mars rover has started a road trip that will continue through the summer across roughly a mile (1.6 kilometers) of terrain. By trip’s end, the rover will be able to ascend to the next section of the 3-mile-tall Martian (5-kilometer-tall) mountain it’s been exploring since 2014, searching for conditions that may have supported ancient microbial life.

Located on the floor of Gale Crater, Mount Sharp is composed of sedimentary layers that built up over time. Each layer helps tell the story about how Mars changed from being more Earth-like — with lakes, streams and a thicker atmosphere — to the nearly-airless, freezing desert it is today.

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Wiring a New Path to Scalable Quantum Computing

Last year, Google produced a 53-qubit quantum computer that could perform a specific calculation significantly faster than the world’s fastest supercomputer. Like most of today’s largest quantum computers, this system boasts tens of qubits—the quantum counterparts to bits, which encode information in conventional computers.

To make larger and more useful systems, most of today’s prototypes will have to overcome the challenges of stability and scalability. The latter will require increasing the density of signaling and wiring, which is hard to do without degrading the system’s stability. I believe a new circuit-wiring scheme developed over the last three years by RIKEN’s Superconducting Quantum Electronics Research Team, in collaboration with other institutes, opens the door to scaling up to 100 or more qubits within the next decade. Here, I discuss how.

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Researchers from the Facility for Rare Isotope Beams (FRIB) Laboratory at Michigan State University (MSU) have taken a major step toward a theoretical first-principles description of neutrinoless double-beta decay. Observing this yet-unconfirmed rare nuclear process would have important implications for particle physics and cosmology. Theoretical simulations are essential to planning and evaluating proposed experiments. The research team presented their results in an article recently published in Physical Review Letters.

FRIB theorists Jiangming Yao, research associate and the lead author of the study, Roland Wirth, research associate, and Heiko Hergert, assistant professor, are members of a topical collaboration on fundamental symmetries and . The U.S. Department of Energy Office of Science Office of Nuclear Physics is funding the topical collaboration. The theorists joined forces with fellow topical collaboration members from the University of North Carolina-Chapel Hill and external collaborators from the Universidad Autonoma de Madrid, Spain. Their work marks an important milestone toward a theoretical calculation of neutrinoless double-beta decay rates with fully controlled and quantified uncertainties.

The authors developed the In-Medium Generator-Coordinate Method (IM-GCM). It is a novel approach for modeling the interactions between nucleons that is capable of describing the complex structure of the candidate nuclei for this decay. The first application of IM-GCM to the computation of the neutrinoless double beta decay rate for the nucleus of calcium-48 sets the stage for explorations of the other candidates with controllable theoretical uncertainty.

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