Lifeboat Foundation

To tackle this problem, researchers at the RIKEN Center for Biosystems Dynamics Research identified a gel that closely mimics the physicochemical properties of organs that have undergone the tissue clearing process. Starting with computer simulations and following up with laboratory tests, the team optimized the soaking solution temperature, dye and antibody concentrations, chemical additives, and electrical properties to produce the best staining and imaging results. They then tested their method with more than two dozen commonly used dyes and antibodies on mouse and marmoset brains.

Scans of an entire mouse brain and one hemisphere of a marmoset brain—rendered into 3D using light sheet microscopy—revealed the similarity between the two animals’ neural vascular systems, showing the use of the system for comparative anatomy, the researchers report this week in. They also showed that they could simultaneously stain and image up to four molecular targets in a mouse brain, a feat that “has never been reported before,” says Ludovico Silvestri, of the European Laboratory for Non-linear Spectroscopy, who was not involved in the research.

The team also used its technique to image an entire infant marmoset and a small human brain sample—something that could one day lead to new understandings of solid tumors and neurodegenerative diseases. The team says its approach to optimizing staining can be applied to other techniques to advance the entire field of 3D imaging.

Five of the world’s biggest central banks recently announced that they’ve banded together to seriously explore central bank digital currencies.

Boston biopharma startup resTORbio Inc. is revamping its pipeline to focus on cancer cell therapies through a reverse-merger.

Both studies were based on reviewing patients’ records, which does not provide evidence as strong as the results of controlled clinical trials, where patients are picked at random to take one treatment or another 🙄.

People taking widely used medicines did not face higher rates of infection or more severe illness, new research indicates.

Looking for expert advice for managing remote teams over Zoom? @KeithFerrazzi is my go-to leader on coaching high-performance executive teams, and recently he’s been working with the CEO of Zoom, to bring best practices to the largest corporations on the planet.

The small intestine is one of the most important interfaces between the environment and our body. It is responsible for nutrient absorption but also forms a barrier against potentially harmful environmental cues. A research team, led by researchers from the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena, Germany, investigated the effects of aging and diet on the intestinal epithelium of young and old mice. They were able to show region-specific effects on the proteome and age-related impairments in adaptation to nutrient availability. Their results provide a complete picture of the spatial organization of the small intestine proteome in the mouse. The results were published in the journal Cell Reports.

The small intestine (SI) is one of the most important interfaces between the environment and our body. It has two major functions: it is responsible for absorbing nutrients from the food we eat and functions as a barrier to restrict the entry of harmful substances. The SI is a highly adaptive and dynamic organ, as it adapts to changes in nutrient intake or diet. The intestinal epithelium undergoes a process of continuous renewal, every 3–5 days.

Effects of aging and diet on the small intestine have already been investigated. It is known that aging leads to reduced absorption of nutrients by the epithelium thus contributing to malnutrition in elderly people. In addition, anatomical differences between different regions of the SI are well known, but so far, region-specific effects of aging and diet on the set of proteins that compose the intestinal epithelium had not been investigated.

Liz Parrish, founder and CEO of BioViva USA Inc., together with Dr. Sewell from Integrated Health Systems (IHS), interviewed by James Strole, Director of the Coalition for Radical Life Extension (CRLE) and Co-Founder of People Unlimited Inc., and Joe Bardin, Communications Director of the CRLE.
The interview took place on April 25, 2020.

The Coalition of Radical Life Extension are de producers of the anual event RAADfest (Revolution Against Aging and Death Festival) which will take place this year in Las Vegas, October 1 — 4. I highly recommend you consider attending this event so take a look at https://www.raadfest.com/

Continue reading “Liz Parrish and Dr. Sewell at the Coalition for Radical Life Extension Webinar (April 2020)” »

Well, every dark cloud does have a silver lining. Out of nearly three million confirmed cases of coronavirus, 1.77 million are mild cases, and more than 807,050 people have recovered as of the time of my writing this.

I think it is fair to say that a vast majority of human beings on planet Earth have one question in their minds: When will we have an actual vaccine?

Well, I have some good news.

SpaceX has announced that it will mount a sun visor on each of its Starlink satellites and have them perform controlled maneuvers, to make them less visible to members of the astronomy community making detailed observations of the night sky. SpaceX has already launched over 400 satellites to bolster a constellation that could one day provide global broadband internet access.

The proliferation of satellite technology and the increasing affordability of reaching low-Earth orbit (LEO) has led many – particularly those in the science community – to raise concerns about the impact that space traffic may have on the night sky. This issue has only grown more contentious with the advent of the megaconstellation, which is the term used to describe vast swarms of satellites working as a network as they fly choreographed orbits through LEO space.

SpaceX’s Starlink megaconstellation is well underway to becoming a reality, and could one day provide high-speed, low latency satellite-based broadband on a global scale.