Thanks to the latest satellite data, we’ve observed storms with massive wave heights, potentially towering over 100 feet above the ocean’s surface.
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Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer
Mosley et al. investigate the role of cytosolic DNA structure in activation of cGAS/STING by MSI colorectal cancers. They find MSI cytosolic DNA is enriched in G-quadruplexes, leading to more effective cGAS/STING activation. Micronuclei are less effective at activating cytotoxic T cells through cGAS/STING but increase IL-10 and Treg activation.
Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity
Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction. During an acute fast in humans, obesity and elevated insulin promoted lean mass loss in males but not females.
Important for the prevention and management of mineral and bone disorders from chronic electrolyte imbalance👇
https://doi.org/10.1172/jci.insight.
Robert A. Fenton & team show that a diet low in potassium causes bone loss in mice, effects that are attributable to altered calcium absorption by the kidney.
The figure shows deep learning instance segmentation model to identify kidney tubules and indicates low dietary K+ intake alters the abundance of the calcium-sensing receptor.
1Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.
2Department of Biomedicine, Aarhus University, Aarhus, Denmark.
3Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
The Speculative Evolution of Project Hail Mary
Project Hail Mary, a story by Andy Weir (author of The Martian), features some of the most creative speculative evolution scenarios in modern science fiction. With the release of the film adaptation starring Ryan Gosling, now seemed like a great time to explore the speculative biology of the aliens in this story: the Astrophage and the Eridians (Rocky’s species).
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Scp: gallionic
Check out the Kickstarter page and help us make this project a reality: https://www.kickstarter.com/projects/glnc/scp-gallionic
Our goal is to make a full 20 minute long animated SCP short film, and have been preparing the groundwork for it for over two years now! Finally, we get to share this with the whole world, in the hopes to make this project a reality!
Based on the SCP wiki, licensed under CC BY-SA 4.
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