A new study links fatty acid metabolism to rheumatoid arthritis treatment, revealing a natural compound that disrupts inflammation by targeting a previously overlooked enzyme.
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Negative effects of artificial sweeteners may pass on to next-generation, study suggests
Health organizations are starting to raise concerns about the potential long-term impacts of artificial sweeteners, which taste sweet but—unlike sugar—contain no calories, suggesting they could interfere with energy metabolism and increase the eventual risk of diabetes or cardiovascular disease.
Now a new study in mice indicates that the popular sweeteners sucralose and stevia have negative effects on the gut microbiome and gene expression, potentially compromising metabolic health, which can be transmitted between generations.
“We found it intriguing that despite the growing consumption of these additives, the prevalence of obesity and metabolic disorders such as insulin resistance has not declined,” said Dr. Francisca Concha Celume of the Universidad de Chile, lead author of the article in Frontiers in Nutrition.
The Universe might not be flat (and cosmologists are quietly freaking out)
Everything we know about the shape of the Universe could be completely wrong.
This is one of the most fascinating unsolved problems in cosmology, and it almost never gets talked about outside of research papers. It’s called the curvature tension, and it links in to the \.
You have no free will at all | Stanford professor Robert Sapolsky
Become a Big Think member to unlock expert classes, premium print issues, exclusive events and more: https://bigthink.com/membership/?utm_… How your biology and environment make your decisions for you, according to Dr. Robert Sapolsky.
Up next, Your reptilian brain, explained ► • Your reptilian brain, explained | Robert S…
Robert Sapolsky, PhD is an author, researcher, and professor of biology, neurology, and neurosurgery at Stanford University. In this interview with Big Think’s Editor-in-Chief, Robert Chapman Smith, Sapolsky discusses the content of his most recent book, “Determined: The Science of Life Without Free Will.”
Being held as a child, growing up in a collectivist culture, or experiencing any sort of brain trauma – among hundreds of other things – can shape your internal biases and ultimately influence the decisions you make. This, explains Sapolsky, means that free will is not – and never has been – real. Even physiological factors like hunger can discreetly influence decision making, as discovered in a study that found judges were more likely to grant parole after they had eaten.
This insight is key for interpreting human behavior, helping not only scientists but those who aim to evolve education systems, mental health research, and even policy making.
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Do We Have Free Will? with Robert Sapolsky & Neil deGrasse Tyson
Is there a quantum reason we could have free will? Neil deGrasse Tyson and comedian Chuck Nice explore the concept of free will and predetermination with neuroscientist, biologist, and author of Determined: The Science of Life Without Free Will, Robert Sapolsky.
A special thanks from our editors to Robert Sapolsky’s dog.
Could we put an end to the question of whether or not we have free will? Discover “The Hungry Judge Effect” and how little bits of biology affect our actions. We break down a physicist’s perspective of free will, The Big Bang, and chaos theory. Is it enough to just feel like we have free will? Why is it an issue to think you have free will if you don’t?
We discuss the difference between free will in big decisions versus everyday decisions. How do you turn out to be the type of person who chooses vanilla ice cream over strawberry? We explore how quantum physics and virtual particles factor into predetermination. Could quantum randomness change the actions of an atom? How can society best account for a lack of free will? Are people still responsible for their actions?
What would Chuck do if he could do anything he wanted? We also discuss the benefits of a society that acknowledges powers outside of our control and scientific advancements made. How is meritocracy impacted by free will? Plus, can you change if people believe in free will if they have no free will in believing so?
Thanks to our Patrons Pro Handyman, Brad K. Daniels, Starman, Stephen Somers, Nina Kane, Paul Applegate, and David Goldberg for supporting us this week.
Groundbreaking Study on Chimp Warfare Shows Us the Nature of War
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Hello and welcome! My name is Anton and in this video, we will talk about war and what it means in the animal kingdom
Links:
https://www.science.org/doi/epdf/10.1… #science #chimps.
0:00 War never changes — but what is war?
2:28 Gombe Chimp War in the 1970s
4:30 New study — largest war ever
5:20 Ngogo chimp project
5:55 Something happened in 2014 resulting in violence
7:20 Why did the violence start?
8:40 Implications for humans
9:45 Ant warfare
11:40 What does this tell us about our nature?
12:55 Conclusions.
Enjoy and please subscribe.
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DAMPE satellite reveals cosmic rays share spectral break near 15 teravolts
A century after their discovery, cosmic rays—particles of extreme energy originating from the far reaches of the universe—remain a mystery to scientists. The DAMPE (Dark Matter Particle Explorer) space telescope is tackling this phenomenon, particularly investigating the role that dark matter may play in their formation. This international mission, which includes the University of Geneva (UNIGE), has made a major breakthrough by highlighting a universal feature of these particles. The results are published in the journal Nature.
Cosmic rays are the most energetic particles observed in the universe, far surpassing the energies of particles produced by man-made accelerators on Earth. Their exact origin is still under study, and it is believed that they originate from extreme astrophysical phenomena, such as supernovae, black hole jets, or pulsars.
The DAMPE space telescope, launched in December 2015, aims to provide answers regarding the origin and nature of these cosmic rays. This space mission, with the astrophysics group from the Department of Nuclear and Particle Physics (DPNC) at the University of Geneva (UNIGE) being one of its main contributors, has made a crucial breakthrough. Through the analysis of high-precision measurements collected by the telescope, scientists have identified a universal feature in the energy spectra of primary cosmic ray nuclei, ranging from protons to iron.
Abstract: SLC26A4-gene mutations are a frequent cause of hereditary HearingLoss
SLC26A4-gene mutations are a frequent cause of hereditary HearingLoss.
https://doi.org/10.1172/JCI193812 Here, Tsai et al. report that targeted AAV delivery to the endolymphatic sac and cochlear lateral wall restores auditory physiology and ameliorates cochlear pathology in a mouse model of Slc26a4-related deafness. Pendred syndrome DFNB4.
The image shows an AAV-GFP–transduced spiral prominence, a structure within the cochlear lateral wall. GFP (green) marks successfully transduced cells, phalloidin-568 (red) labels the actin cytoskeleton, and DAPI (blue) stains nuclei, highlighting efficient gene transfer to inner ear tissues essential for auditory function.
Address correspondence to: Chen-Chi Wu, Department of Otolaryngology, National Taiwan University Hospital, No. 1, Changde St., Zhongzheng Dist., Taipei City 100,229, Taiwan. Phone: 886.2.2312.3456; Email: [email protected]. Or to: Yen-Fu Cheng, Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 11,217, Taiwan. Phone: 886.2.2875.7642; Email: [email protected].
Find articles by Tsai, Y. in: | Google Scholar
1Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Diabetes flips immune cells from repair to inflammation in peripheral artery disease, study finds
Type 2 diabetes can turn immune cells that help with tissue repair and anti-inflammatory responses into triggers of chronic inflammation. A recent study investigated why people with type 2 diabetes are at a higher risk of severe complications from peripheral artery disease (PAD).
PAD is a common circulatory condition in which plaque buildup narrows the arteries, reducing blood flow, usually in the legs. This can lead to lower extremity infections and the formation of non-healing ulcers in people with diabetes.
Using RNA-sequencing and gene mapping, researchers discovered that diabetes causes certain immune cells called macrophages that express the protein TREM2 to reprogram their behavior from helping cells repair to causing harmful inflammation and preventing blood vessels from healing. The findings were published in Science Translational Medicine.
