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NAD Coenzymes, Metabolic Stress, And Novel Preventative And Therapeutic Interventions — Dr. Charles Brenner, Ph.D., City of Hope.

Dr. Charles Brenner Ph.D. is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism, and Professor and Chair of the Department of Diabetes & Cancer Metabolism, at the City of Hope Comprehensive Cancer Center (https://www.cityofhope.org/faculty/charles-brenner).

With his Ph.D. in Cancer Biology from Stanford University, Dr. Brenner’s laboratory focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress (https://www.cityofhope.org/charles-brenner-lab).

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Health Innovation Investment For The Future Generations — Dr. Aboubacar Kampo, MD, MPH — Director of Health Programs — UNICEF.

Dr. Aboubacar Kampo, MD, MPH is the Director of Health Programs at UNICEF (UN Headquarters) where he provides strategic leadership, management support and overall direction to UNICEF’s global health program.

UNICEF, also known as the United Nations Children’s Emergency Fund, is a United Nations agency responsible for providing humanitarian and developmental aid to children worldwide. The agency is among the most widespread and recognizable social welfare organizations in the world, with a presence in 192 countries and territories. UNICEF’s activities include providing immunizations and disease prevention, administering treatment for children and mothers with HIV, enhancing childhood and maternal nutrition, improving sanitation, promoting education, and providing emergency relief in response to disasters.

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From 3 day weekends to a future where all the jobs you do not want to do are automated, leaving you to spend your time as you desire.
Learning and research.
Sport and recreation.
Tourism and adventure.
Or whatever takes your fancy…

Well 4 day working weeks are already arriving, and I then show the rate of break throughs in Artificial Intelligence in just the last decade, which are removing the repetition and boredom from our jobs, so we can spend more time on the bits that matter and that are of interest.

What do you think?

Let us know your thoughts in the comments.

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We have a much better understanding of physics than we do of consciousness. I consider ways in which intrinsically mental aspects of fundamental ontology might induce modifications of the known laws of physics, or whether they could be relevant to accounting for consciousness if no such modifications exist. I suggest that our current knowledge of physics should make us skeptical of hypothetical modifications of the known rules, and that without such modifications it’s hard to imagine how intrinsically mental aspects could play a useful explanatory role. Draft version of a paper submitted to Journal of Consciousness Studies, special issue responding to Philip Goff’s Galileo’s Error: Foundations for a New Science of Consciousness.

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“There was cheering in the control center” when word came that NASA had brought a key computer back, says James Jeletic, the Hubble project’s deputy project manager.

The Hubble Space Telescope is returning to operation more than a month after its original payload computer shut down. NASA said it has successfully switched over to its backup computer — and while the process of bringing the system back online is slow, the agency has started to bring science instruments out of “safe mode.”

“There was cheering in the control center” on Thursday night when word came that NASA had managed to restore the payload computer, James Jeletic, Hubble’s deputy project manager, told NPR.

“There’s a big sense of relief,” Jeletic said.

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A star in a distant galaxy blew up in a powerful explosion, solving an astronomical mystery.

Dr. Iair Arcavi, a Tel Aviv University researcher at the Raymond and Beverly Sackler Faculty of Exact Sciences, participated in a study that discovered a new type of stellar explosion — an electron-capture supernova. While they have been theorized for 40 years, real-world examples have been elusive. Such supernovas arise from the explosions of stars 8–9 times the mass of the sun. The discovery also sheds new light on the thousand-year mystery of the supernova from A.D. 1054 that was seen by ancient astronomers, before eventually becoming the Crab Nebula, that we know today.

A supernova is the explosion of a star following a sudden imbalance between two opposing forces that shaped the star throughout its life. Gravity tries to contract every star. Our sun, for example, counter balances this force through nuclear fusion in its core, which produces pressure that opposes the gravitational pull. As long as there is enough nuclear fusion, gravity will not be able to collapse the star. However, eventually, nuclear fusion will stop, just like gas runs out in a car, and the star will collapse. For stars like the sun, the collapsed core is called a white dwarf. This material in white dwarfs is so dense that quantum forces between electrons prevent further collapse.

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Most of the tests that doctors use to diagnose cancer — such as mammography, colonoscopy, and CT scans — are based on imaging. More recently, researchers have also developed molecular diagnostics that can detect specific cancer-associated molecules that circulate in bodily fluids like blood or urine.

MIT engineers have now created a new diagnostic nanoparticle that combines both of these features: It can reveal the presence of cancerous proteins through a urine test, and it functions as an imaging agent, pinpointing the tumor location. In principle, this diagnostic could be used to detect cancer anywhere in the body, including tumors that have metastasized from their original locations.

“This is a really broad sensor intended to respond to both primary tumors and their metastases. It can trigger a urinary signal and also allow us to visualize where the tumors are,” says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science at MIT and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science.

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Experiments now online or being built in Japan, South Korea, Italy, Canada and the United States are an order of magnitude more sensitive than the previous generation, and planned future detectors would improve on that by another two orders of magnitude (see ‘Experiments around the world’). In 2015, an advisory committee to the US Department of Energy identified such a project as a priority and a commitment to fund an experiment to detect Majorana neutrinos — estimated to cost up to/around US$250 million — is thought to be imminent.

The search for exotic ‘Majorana’ particles that could solve a big antimatter mystery is ramping up around the world.

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A new set of equations can precisely describe the reflections of the Universe that appear in the warped light around a black hole.

The proximity of each reflection is dependent on the angle of observation with respect to the black hole, and the rate of the black hole’s spin, according to a mathematical solution worked out by physics student Albert Sneppen of the Niels Bohr Institute in Denmark.

This is really cool, absolutely, but it’s not just really cool. It also potentially gives us a new tool for probing the gravitational environment around these extreme objects.

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