Menu

Blog

Page 6285

Aug 27, 2020

Fungi In The Blood, Fungi In The Brain: Rapamycin To The Rescue?

Posted by in categories: biotech/medical, life extension, neuroscience

Here’s my latest video!


The incidence of fungi bloodstream infections increases during aging-is that a potential explanation for the presence of fungi in the brains of Alzheimer’s disease patients? Rapamycin is a known antifungal-is it effective against fungi that are found in the blood and brain?

Aug 27, 2020

Cardiology trial shows potential benefit of genetic testing when selecting blood thinners

Posted by in categories: biotech/medical, genetics

An international, first-of-its-kind cardiology trial used personalized genetic testing to reduce by 34 percent the number of serious adverse events following balloon angioplasty, a treatment for the most common form of heart disease.

For patients undergoing (PCI)—a non-surgical procedure where physicians inflate a balloon and place a metal stent in narrowed arteries to improve to the heart —the choice of antiplatelet therapy can be critical to post-treatment success, and to minimize the chance of heart attack or stroke.

The TAILOR-PCI trial, co-led by principal investigators Dr. Michael Farkouh, cardiologist and Multinational Clinical Trials Chair at the Peter Munk Cardiac Centre and Dr. Naveen Pereira, Professor of Medicine and cardiologist at Mayo Clinic, studied the effectiveness of genetic-guided therapy in patients that have had PCIs when compared to conventional therapy.

Aug 27, 2020

LG officially announces its battery-powered air purifier mask

Posted by in categories: biotech/medical, wearables

LG has officially announced a portable air purifier that you wear on your face like a mask. The PuriCare Wearable Air Purifier uses a pair of replaceable filters similar to what you’d find in LG’s range of air purifiers for the home, pairing them with battery-powered fans to help you breathe. LG says the device has sensors to detect when you’re breathing in or out, and adjusts the fans’ speeds accordingly.

Today’s announcement ahead of IFA 2020 doesn’t explicitly mention the COVID-19 pandemic, but it heavily implies that the mask was developed in response to it. The company says the wearable air purifier is designed to replace the “inconsistent” homemade masks worn by some people, as well as the disposable masks that it says have been in short supply.

Back in July, when LG first announced the mask and said it would be donating 2,000 of the devices to a university hospital in Seoul, one executive from the company said they hoped it would help medical staff “amid the protracting COVID-19 pandemic,” The Korea Herald reported. They hoped it would make it easier for medical staff to wear a mask for hours at a time.

Aug 27, 2020

Rejuvenating old organs could increase donor pool

Posted by in categories: biotech/medical, life extension

Very interesting.


Despite the limited supply of organs available for patients on waitlists for transplantation, organs from older, deceased donors are frequently discarded or not utilized. Available older organs have the potential to close the gap between demand and supply that is responsible for the very long wait-times that lead to many patients not surviving the time it takes for an organ to become available. Older organs can also often provoke a stronger immune response and may put patients at greater risk of adverse outcomes and transplant rejection. But, as the world population ages, organs from older, deceased donors represent an untapped and growing resource for patients in need. Investigators from Brigham and Women’s Hospital are leading efforts to breathe new life into older organs by leveraging a new class of drugs known as senolytics, which target and eliminate old cells. Using clinical and experimental studies, the team presents evidence that senolytic drugs may help rejuvenate older organs, which could lead to better outcomes and a wider pool of organs eligible for donation. Results are published in Nature Communications.

“Older organs are available and have the potential to contribute to mitigating the current demand for organ transplantation,” said corresponding author Stefan G. Tullius, MD, Ph.D., chief of the Division of Transplant Surgery at the Brigham. “If we can utilize older organs in a safe way with outcomes that are comparable, we will take a substantial step forward for helping patients.”

Continue reading “Rejuvenating old organs could increase donor pool” »

Aug 27, 2020

Blocking nerve signals to the pancreas halts type 1 diabetes onset in mice

Posted by in category: biotech/medical

Your pancreas is a little sweet potato-shaped organ that sits snug behind your stomach. The pancreas is studded with islets, the cell clusters that house insulin-producing beta cells. In people with type 1 diabetes, the body’s own immune cells head for the islets and start attacking the beta cells. No one knows exactly what triggers this attack.

One clue may lie in the pattern of beta cell death. Many beta are killed off in big patches while other beta cells are mysteriously untouched. Something seems to be drawing to attack specific groups of while ignoring others.

In a new Science Advances study, researchers at La Jolla Institute for Immunology (LJI) report that the nervous system may be driving this patchy cell die-off. Their new findings in a mouse model suggest that blocking nerve signals to the pancreas could stop patients from ever developing type 1 diabetes.

Aug 27, 2020

Transplanted brown-fat-like cells hold promise for obesity and diabetes

Posted by in categories: biotech/medical, genetics

Obesity is the main cause of type 2 diabetes and related chronic illnesses that together will kill more people around the globe this year than the COVID-19 coronavirus. Scientists at Joslin Diabetes Center have delivered a proof of concept for a novel cell-based therapy against this dangerous condition.

The potential therapy for obesity would transplant HUMBLE (human brown-like) , human white fat cells that have been genetically modified to become similar to heat-generating , says Yu-Hua Tseng, Ph.D., a Senior Investigator in Joslin’s Section on Integrative Physiology and Metabolism.

Brown fat cells burn energy instead of storing energy as white fat cells do, says Tseng, senior author on a paper about the work in Science Translational Medicine. In the process, brown fat can lower excessive levels of glucose and lipids in the blood that are linked to metabolic diseases such as .

Aug 27, 2020

New Ground Station Brings Laser Communications Closer To Reality

Posted by in category: satellites

Optical communications, transmitting data using infrared lasers, has the potential to help NASA return more data to Earth than ever. The benefits of this technology to exploration and Earth science missions are huge. In support of a mission to demonstrate this technology, NASA recently completed installing its newest optical ground station in Haleakala, Hawaii.

The state-of-the-art ground station, called Optical Ground Station 2 (OGS-2), is the second of two optical ground stations to be built that will collect data transmitted to Earth by NASA’s Laser Communications Relay Demonstration (LCRD). Launching in early 2021, this trailblazing mission will be the linchpin in NASA’s first operational optical communications relay system. While other NASA efforts have used optical communications, this will be NASA’s first relay system using optical entirely, giving NASA the opportunity to test this method of communications and learn valuable lessons from its implementation. Relay satellites create critical communications links between science and exploration missions and Earth, enabling these missions to transmit important data to scientists and mission managers back home.

egg-looking optical telescope dome

Aug 27, 2020

New $115 Million Quantum Systems Accelerator to Pioneer Quantum Technologies for Discoveries That Benefit the World

Posted by in category: quantum physics

Berkeley Lab-led center to catalyze U.S. leadership in quantum information science, and strengthen the nation’s research community to accelerate commercialization.

The Department of Energy (DOE) has awarded $115 million over five years to the Quantum Systems Accelerator (QSA), a new research center led by Lawrence Berkeley National Laboratory (Berkeley Lab) that will forge the technological solutions needed to harness quantum information science for discoveries that benefit the world. It will also energize the nation’s research community to ensure U.S. leadership in quantum R&D and accelerate the transfer of quantum technologies from the lab to the marketplace. Sandia National Laboratories is the lead partner of the center.

Total planned funding for the center is $115 million over five years, with $15 million in Fiscal Year 2020 dollars and outyear funding contingent on congressional appropriations. The center is one of five new Department of Energy Quantum Information Science (QIS) Research Centers announced today (August 26, 2020).

Aug 27, 2020

South Africa to Build USD266 Million Space Hub: Promises Six Satellites

Posted by in categories: satellites, sustainability

South Africa’s President, Cyril Ramaphosa has sourced for a R4.4 billion (USD260 million) investor funding at the sustainable infrastructure development symposium. The South African National Space Agency (SANSA) will receive R3 billion (USD177 million) to develop and design up to six satellites in the next four years. The total funding will incubate South Africa’s Space hub. This information was disclosed by the CEO of SANSA, Val Munsami.


South Africa’s President, Cyril Ramaphosa has sourced for a R4.4 billion (USD260 million) investor funding at the sustainable infrastructure development symposium. The South African National Space Agency (SANSA) will receive R3 billion (USD177 million) to develop and design up to six satellites in the next four years. The total funding will incubate South Africa’s Space hub.

This information was disclosed by the CEO of SANSA, Val Munsami.

Continue reading “South Africa to Build USD266 Million Space Hub: Promises Six Satellites” »

Aug 27, 2020

Study leads to potential for new treatment approach to Alzheimer’s

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Research looking at a possible new therapeutic approach for Alzheimer’s disease was recently published in the Journal of Neuroinflammation. The paper out of the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) is titled “Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition”. The work looked at targeting inflammation by using an antibody. Alzheimer’s disease and related dementias have no disease-modifying treatments at this time and represent a looming public health crisis given the continually growing aging population.

The paper explains that current therapeutic approaches to the treatment of Alzheimer’s focus on the major pathological hallmarks of the disease which are and neurofibrillary tangles. They are the requirements for a diagnosis of Alzheimer’s disease. However, the authors say there has been an explosion of genetic data suggesting the risk for sporadic Alzheimer’s disease is driven by several other factors including neuroinflammation, membrane turnover and storage, and .

In this study the researchers focused on triggering receptor expressed on myeloid cell-2 (TREM2). “TREM2 was identified several years ago as a gene that, when there’s a mutation, significantly increases risk of Alzheimer’s disease. The field thinks that this mutation reduces the function of the receptor, so we hypothesized that targeting TREM2 to increase its function might be a valid treatment for Alzheimer’s,” explained Donna Wilcock, SBCoA associate director.