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Scientists have discovered that a medication already approved for treating multiple sclerosis and psoriasis shows remarkable promise in combating periodontitis, one of the leading causes of tooth loss worldwide.

Researchers from Wenzhou Medical University found that dimethyl fumarate (DMF) significantly reduced bone loss and inflammation in experimental models of gum disease by improving cellular “cleanup” mechanisms and shifting immune responses toward healing rather than destruction.

“Dimethyl fumarate’s ability to fine-tune macrophage polarization through mitophagy is a game-changer in periodontal therapy,” said Dr. Shengbin Huang, the study’s corresponding author. “By targeting the mitochondrial protein TUFM, we uncovered a molecular switch that controls the inflammatory response in gum tissue. These insights could redefine how we treat chronic inflammatory conditions beyond the oral cavity.”

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Scientific article mentioned:
https://link.springer.com/article/10.1007/s10522-025-10240-z.

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As humans and other animals navigate their surroundings and experience different things, their brain creates so-called cognitive maps, which are internal representations of environments or tasks. These mental maps are eventually generalized into schemas, frameworks that organize information acquired through experience and can later guide decision-making.

Various past neuroscience and psychology studies have tried to better understand the neural processes and brain regions that support the formation of these internal representations. Insight into these mechanisms could, in turn, shed light on the underpinnings of learning and decision-making.

Two brain regions that have been found to play a role in forming internal representations of experiences are the (OFC) and the hippocampus (HC). Among other functions, the OFC supports reward-based learning and decision-making. At the same time, the HC contributes to spatial navigation and the formation and retrieval of memories.

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In the double-blind study, 29 patients with various mood and anxiety disorders received MRI-guided focused ultrasound to the left amygdala.

The results showed both immediate reductions in amygdala activity, and after three weeks of daily sessions, patients experienced clinically significant improvements in negative affect and symptoms of depression, anxiety and PTSD.

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Multimodal results (iEEG, fMRI and MEG) of predictions from integrated information theory and global neuronal workspace theory align with some predictions of both theories on visual consciousness, but also critically challenge key tenets of both theories.

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Everything related to the human brain and neuroscience has always been an area in which specialists have said that there is much to discover, learn and investigate. In fact, the generation of memory in human beings, memories, and the different diseases that are clustered around the CPU of the body have always been constantly evolving.

Now, Dr. Tomas Ryan of Trinity College Dublin, a neuroscientist who has explored the issues of brain learning by tracking the cells involved in this process, has found new findings suggesting that memory formation depends on the connections between groups of engram cells, neurons thought to capture and store distinct experiences.

In this new research, the experts indicate that each experience leaves a pattern of neuronal activation that can be activated later, which would mean the creation of a memory. To reach this conclusion, the neuroscientists tracked two sets of engram cells, each linked to a different memory.

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